The Citizens have been in incredible form, winning their last 20 games across all competitions. Manchester City came away with all three points against David Moyes' West Ham on Saturday, courtesy of goals from John Stones and Ruben Dias.
Pep Guardiola will hope his side can add to their 12 point lead at the top of the Premier League table against the Wolves.
Wolves, on the other hand, have been very inconsistent this season. Nuno Espirito Santo's side have struggled to string together wins consistently and currently lie 12th in the Premier League. Wolves are, however, on a 3-match unbeaten streak, coming off a 1-1 draw against Newcastle on Sunday.
Pep Guardiola will hope his side can continue their winning streak on Tuesday, but Wolves could be a tricky fixture for Manchester City.
Manchester City vs Wolves Head-to-Head
The recent head-to-head meetings between the two sides have been split evenly. Both sides have two wins out of their last five Premier League clashes against each other.
Manchester City did however come away as 3-1 winners in the reverse fixture earlier this season.
Manchester City Form Guide: W-W-W-W-W
Wolves Form Guide: D-L-W-W-D
Manchester City vs Wolves Team News
Pep Guardiola will have a full strength squad to pick from against Wolves on Tuesday, with only 4th choice centre-back Nathan Ake unavailable through injury.
The Manchester City boss will however most likely make a few changes to the side that beat West Ham 2-1 on Saturday.
Injured: Nathan Ake
Nuno Espirito Santo will be without a few key players for their trip to the Etihad on Tuesday. Daniel Podence will miss a few weeks due to a tear in his abductor muscle. Star striker Raul Jimenez is also out as he is still recovering from the fractured skull that he suffered last November.
French centre-back Willy Boly is also a doubt for the game, having picked up a knock last week.
Injured: Daniel Podence, Raul Jimenez
Doubtful: Willy Boly
Manchester City vs Wolves Predicted XI
Manchester City Predicted XI (4-3-3): Ederson; Joao Cancelo, Ruben Dias, John Stones, Kyle Walker; Rodri, Phil Foden, Kevin De Bruyne; Raheem Sterling, Riyadh Mahrez, Gabriel Jesus
Wolves Predicted XI (3-4-3): Rui Patricio; Romain Saiss, Conor Coady, Leander Dendoncker; Jonny, Joao Moutinho, Ruben Neves, Nelson Semedo; Adama Traore, Pedro Neto, Willian Jose
Manchester City vs Wolves Prediction
It's hard to see Wolves coming away with anything on Tuesday. Pep Guardiola's side look unstoppable at the moment and should be able to easily deal with anything that Wolves throw at them.
We predict a comfortable win for Manchester City
Prediction: Manchester City 2-0 Wolves