Manchester United are back in action with another crucial Premier League fixture this week as they take on a formidable Southampton outfit at Old Trafford on Tuesday. Both teams can be impressive on their day and will look to seize the initiative in this fixture.Southampton have largely exceeded expectations over the past few months but have endured a difficult slump in recent weeks. The Saints have lost three games on the trot and will look to pull off an upset in this match.Manchester United are a legitimate contender for the Premier League title this season but have plenty of work to do to give arch-rivals Manchester City a run for their money. The Red Devils have managed only one point from their last two matches and cannot afford to slip up against Southampton.Never give up ⛔#MUFC @AWBissaka https://t.co/ycTV6v5XNY pic.twitter.com/3zdRarwlnq— Manchester United (@ManUtd) January 31, 2021Manchester United vs Southampton Head-to-HeadManchester United have an excellent record against Southampton and have won 66 matches out of a total of 128 games played between the two teams. Southampton have managed 34 victories against Manchester United and can potentially trouble their opponents this week.The previous meeting between the two teams took place in November last year and ended in an exhilarating 3-2 victory for Manchester United. Bruno Fernandes and Edinson Cavani were exceptional on the day and will look to pull off a similar result in this match.Manchester United form guide in the Premier League: D-L-W-D-WSouthampton form guide in the Premier League: L-L-L-W-DAlso Read: 10 greatest managers in Serie A historyManchester United vs Southampton Team NewsManchester United have a strong squadManchester UnitedPhil Jones is currently nursing an injury and has been ruled out of this fixture. Scott McTominay is also carrying a knock and is unlikely to be risked against Southampton this week.Injured: Phil JonesDoubtful: Scott McTominaySuspended: NoneSouthampton have a depleted squadSouthamptonTheo Walcott, Jannik Vestergaard, Oriol Romeu, and Ibrahima Diallo currently have fitness concerns and might not feature in this game. Kyle Walker-Peters, Nathan Tella, and Mohammed Salisu are injured and have been sidelined against Manchester United.Injured: Kyle Walker-Peters, Nathan Tella, Mohammed Salisu, Michael Obafemi, William SmallboneDoubtful: Theo Walcott, Jannik Vestergaard, Oriol Romeu, Ibrahima DialloSuspended: NoneManchester United vs Southampton Predicted XIManchester United Predicted XI (4-2-3-1): David de Gea; Luke Shaw, Harry Maguire, Eric Bailly, Aaron Wan-Bissaka; Fred, Paul Pogba; Bruno Fernandes, Mason Greenwood, Marcus Rashford; Anthony Martial💬 "We created enough chances to score, but we’ll work on them; we’ll get them going again."More from the boss 👇#MUFC— Manchester United (@ManUtd) January 31, 2021Southampton Predicted XI (4-4-2): Alex McCarthy; Ryan Bertrand, Jack Stephens, Jan Bednarek, Yan Valery; Moussa Djenepo, Alexandre Jankewitz, James Ward-Prowse, Stuart Armstrong; Che Adams, Danny IngsManchester United vs Southampton PredictionManchester United have been excellent under Ole Gunnar Solskjaer this season and will want to arrest their recent slump against Southampton. The likes of Bruno Fernandes and Marcus Rashford have been impressive for the Red Devils and will have to be at their best in this fixture.Southampton have a host of attacking talents in their ranks and will likely set up on the counter on Tuesday. Manchester United are the better team on paper, however, and should be able to win this game.Prediction: Manchester United 2-1 SouthamptonAlso Read: Wolverhampton Wanderers vs Arsenal prediction, preview, team news and more | Premier League 2020-21