The high-profile fixture promises to be an exciting game of football in which some of the very best players in the Portuguese league will be in action.
Benfica are tied with the hosts, having garnered 31 points from 13 games. They are third in the standings, just behind Porto on goal difference.
Porto vs Benfica Head-to-Head
This will the 246th edition of O Clássico. In their previous 245 meetings across all competitions, the Dragões have enjoyed a slight advantage over their arch-rivals.
They have 97 wins to their name, while the Eagles have picked up 88 wins in the fixture. A total of 60 matches in this intriguing contest have ended in draws.
Their last eight meetings have produced conclusive results, with six going Porto's way and Benfica having managed two wins.
These sides last met in the Supertaça Cândido de Oliveira final in December, where the hosts recorded a commanding 2-0 win.
Porto form guide across all competitions: W-W-W-W-W
Benfica form guide across all competitions: W-W-D-W-L
Porto vs Benfica Team News
Sérgio Conceição is expected to be without the services of Chancel Mbemba, Mouhamed Mbaye and Ivan Marcano, on account of their respective injuries.
Carraça, Manafa and Fabio Vieira all tested positive for COVID-19 last week and remain in isolation. Goalkeeper Cláudio Ramos has been out of action due to the virus for over 10 days and his involvement remains in doubt.
Injuries: Ivan Marcano, Chancel Mbemba, Mouhamed Mbaye
Unavailable (due to COVID-19): Carraça, Manafa, Fabio Vieira, Cláudio Ramos
Benfica coach Jorge Jesus will make the trip to the coastal city without Andre Almeida, who is out for the season. Gabriel Pires is also out due to a muscle issue.
Jesus has welcomed back Seferovic and Jardel into the squad after their spell on the sidelines due to COVID-19. They will likely feature in this crucial tie.
João Ferreira also tested positive for the virus almost two weeks ago and his involvement remains in doubt.
Injuries: Gabriel Pires, Andre Almeida
Doubtful: João Ferreira
Porto vs Benfica Predicted XI
Porto Predicted XI (4-2-2): Augustin Marchesin; Zaidu Sanusi, Malang Sarr, Pepe, Nanu; Sergio Oliveira, Mateus Uribe, Jesus Corona, Luis Díaz; Moussa Marega, Mehdi Taremi
Benfica Predicted XI (4-4-2): Odysseas Vlachodimos; Nuno Tavares, Jan Vertonghen, Jean-Clair Todibo, Gilberto; Everton, Julian Weigl, Adel Taarabt, Rafa Silva; Luca Waldschmidt, Darwin Nunez
Porto vs Benfica Prediction
Both Porto and Benfica have been in fine form since the beginning of the 2020-21 campaign. The hosts have been the best scoring side in the division with 35 goals. Meanwhile, the visitors have a better defensive recorded, having shipped in just 13 goals.
The players in both sides are some of the top scorers and top assist-providers in the league. This promises to be an electrifying encounter.
It is always tricky to predict an outcome in matches between two evenly-matched sides. Porto recently got the better of Benfica in a cup tie and we believe they can do it again, given their home advantage.
Prediction: Porto 2-1 Benfica.