The Bundesliga returns with its 2020-21 edition this weekend as a high-flying RB Leipzig outfit take on FSV Mainz 05 at the Red Bull Arena. RB Leipzig have enjoyed a string of successes over the past few years and will look to start the new season on a positive note.FSV Mainz, on the other hand, finished in thirteenth place in the Bundesliga table last season and had their fair share of defensive issues throughout the year. The away side has a dismal record at the Red Bull Arena and conceded an astonishing 13 goals in two games against RB Leipzig last season.RB Leipzig have been in excellent form over the past few weeks and gave a good account of themselves in the Champions League. Julian Nagelsmann's side has lost Timo Werner to Chelsea this summer and will have to adequately replace his impact going into this season.🗣 Julian #Nagelsmann spoke about the team's record against @Mainz05en in his press conference: "The game starts at 0-0. We don't have to repeat what happened last season. For that to happen, we'd need a perfect day."🔴⚪ #DieRotenBullen #RBLM05 pic.twitter.com/Tpzg8iLDfe— RB Leipzig English (@RBLeipzig_EN) September 18, 2020RB Leipzig vs FSV Mainz 05 Head-to-HeadRB Leipzig were Mainz's worst nightmare last season and suffered a devastating 8-0 defeat at the Red Bull Arena last year. Mainz also lost the reverse fixture by a shocking 5-0 margin and have plenty of work to do ahead of this fixture.RB Leipzig are relatively new to the Bundesliga and have played only six official fixtures against FSV Mainz. The home side has managed five victories in this game and should be able to maintain its excellent record over the weekend.RB Leipzig form guide: W-L-W-D-WFSV Mainz 05 form guide: W-L-L-L-LAlso Read: 10 Greatest Football Managers of all timeRB Leipzig vs FSV Mainz 05 Team NewsMarcel Sabitzer may not be fit for this gameRB LeipzigMarcel Sabitzer, Ibrahima Konate, and Konrad Laimer are currently recovering from injuries and may not be able to play a part in this game. Hugo Novoa and Josep Martinez are currently in quarantine and have been ruled out of this fixture.Injured: Hugo Novoa, Josep MartinezDoubtful: Marcel Sabitzer, Ibrahima Konate, Konrad LaimerSuspended: NoneStefan Bell is currently injuredFSV Mainz 05FSV Mainz have their fair share of injury concerns going into this game and might not be able to field several key players. Edimilson Fernandes, Stefan Bell, Pierre Kunde Malong, and Dong-Won Ji are yet to receive the medical all-clear and might have to remain on the sidelines for this game.Injured: NoneDoubtful: Edimilson Fernandes, Stefan Bell, Pierre Kunde Malong, Dong-Won JiSuspended: NoneRB Leipzig vs FSV Mainz 05 Predicted XIRB Leipzig Predicted XI (3-4-2-1): Peter Gulcasi; Lukas Klostermann, Dayot Upamecano, Willi Orban; Angelino, Tyler Adams, Kevin Kampl, Nordi Mukiele; Hee-Chan Hwang, Dani Olmo; Yussuf PoulsenOnly 2️⃣ days to go! 🤩🔴⚪ #DieRotenBullen pic.twitter.com/6U0GXQFrwO— RB Leipzig English (@RBLeipzig_EN) September 18, 2020FSV Mainz 05 Predicted XI (4-1-4-1): Robin Zentner; Daniel Brosinski, Jeremiah St. Juste, Moussa Niakhate, Ridle Baku; Leandro Martins; Jonathan Burkarkt, Danny Latza, Karim Onisiwo, Robin Quaison; Jean-Philippe MatetaRB Leipzig vs FSV Mainz 05 PredictionRB Leipzig have an impeccable record against Mainz and are the undisputed favourites to win this game. Mainz would have studied last season's debacles, however, and may well present a more robust front.RB Leipzig have an excellent attacking combination and the likes of Dani Olmo and Yussuf Poulsen will have to step up in the absence of Timo Werner and Marcel Sabitzer. Julian Nagelsmann's squad is one of the best in the Bundesliga and should be able to win this game.Prediction: RB Leipzig 3-0 FSV Mainz 05Also Read: VfL Wolfsburg vs Bayer Leverkusen prediction, preview, team news and more | Bundesliga 2020-21