The UEFA Champions League is back in action with another round of matches this week as Borussia Dortmund lock horns with Julen Lopetegui's Sevilla at the Estadio Ramon Sanchez Pizjuan on Wednesday.Sevilla vs Borussia Dortmund PreviewBorussia Dortmund are currently in fourth place in the Bundesliga standings and have been fairly impressive so far this season. The German outfit slumped to a 3-2 defeat at the hands of FC Koln over the weekend and will need to bounce back in this fixture.Sevilla, on the other hand, are in 17th place in the La Liga table at the moment and have been shockingly poor this season. The Andalusians suffered a damaging 2-0 defeat against Atletico Madrid in their previous game and have a point to prove this week.Sevilla vs Borussia Dortmund Head-to-Head and Key NumbersBorussia Dortmund and Sevilla are on an even footing as far as the head-to-head record is concerned and have won one game apiece out of four matches played between the two teams.Sevilla's only victory against Borussia Dortmund came away from home in the UEFA Europa League by a 1-0 margin over 12 years ago.The previous two-legged affair between Sevilla and Borussia Dortmund took place in the 2020-21 season and ended in a 5-4 aggregate victory for Borussia Dortmund.Borussia Dortmund have won only one of their last 11 away games against Spanish opponents in the UEFA Champions League but did win their previous such meeting against Sevilla.Borussia Dortmund have lost their last three away games in the UEFA Champions League and have suffered four consecutive away defeats in the competition on only one occasion.Sevilla have never lost consecutive home games in the group stage of the UEFA Champions League.Sevilla vs Borussia Dortmund PredictionSevilla have been in abysmal form so far this season and will be intent on remaining in European competitions in the coming weeks. Julen Lopetegui has a massive task on his hands this season and will face another litmus test on Wednesday.Sevilla FC@SevillaFC_ENGThe hard work never stops! ‍♂️423The hard work never stops! 🏃‍♂️ https://t.co/1UFVWSEJZqBorussia Dortmund can pack a punch on their day and will look to reach the knock-outs this season. The away side are the better team at the moment and should be able to win this game.Prediction: Sevilla 1-2 Borussia Dortmund2 for 1 New Player Bonus at BarstoolSevilla vs Borussia Dortmund Betting TipsTip 1: Result - Borussia DortmundTip 2: Game to have over 2.5 goals - YesBorussia Dortmund@BlackYellowSevilla ahead 58119Sevilla ahead 🔜https://t.co/QW2lfWXBNETip 3: Borussia Dortmund to score first - YesTip 4: Youssoufa Moukoko to score - Yes