Giants vs. Diamondbacks: Game 1 prediction, odds, injuries, and picks

The San Francisco Giants take on the Arizona Diamondbacks on Monday for the first of four games at Chase Field. Coming into this game, San Francisco sits third in the NL West with a 45-39 record, while Arizona is placed a spot worse with a 41-42 record.

Let's take a look at the odds and how the action might play out in this series opener.

Giants vs Diamondbacks prediction

Taking the mound for San Francisco is ace Logan Webb, who has been great so far this year, boasting a 7-5 record, along with a 2.52 ERA and 120 strikeouts.

Logan Webb in action against the Los Angeles Dodgers - Source: Getty

Offensively, Rafael Devers, Jung Hoo Lee, Heliot Ramos and Wilmer Flores have been enjoying plenty of success for the visitors.

For Arizona, Ryne Nelson makes the start. Though not as great as his counterpart, Nelson's numbers have also been quite good so far, with a 4-2 record, along with a 3.71 ERA and 52 strikeouts.

At the plate, Ketel Marte, Eugenio Suarez, Josh Naylor and Geraldo Perdomo are the key players for the Diamondbacks.

Both teams have been far from their best of late, with San Francisco entering this series after losing two out of three to the Chicago White Sox, while Arizona was disappointingly swept by the Miami Marlins at home.

Hence, both teams will be extremely motivated to get back to winning ways in this one. With the pitching matchup leaning in their favor, the visitors are better equipped to manage that.

Prediction: San Francisco Giants 5, Arizona Diamondbacks 4

Odds

Money Line: San Francisco Giants -130, Arizona Diamondbacks +111

Run Line: San Francisco -1.5 (+124), Arizona +1.5 (-154)

Total Runs: Over 7.5 (-139), Under 7.5 (+113)

Injury report

Giants injuries

Matt Chapman: 10-day IL (Hand)
Jerar Encarnación: 10-day IL (Oblique)
Tom Murphy: 60-day IL (Back)
Casey Schmitt: day-to-day (Wrist)

Diamondbacks injuries

Gabriel Moreno: 10-day IL (Hand)
Ildemaro Vargas: 10-day IL (Foot)
Corbin Carroll: 10-day IL (Hand)
Kendall Graveman: 15-day IL (Hip)
Blake Walston: 60-day IL (Elbow)
Corbin Burnes: 60-day IL (Elbow)
A.J. Puk: 60-day IL (Elbow)
Christian Montes De Oca: 60-day IL (Elbow)
Cristian Mena: 60-day IL (Shoulder)
Justin Martinez: 60-day IL (Elbow)
Jordan Montgomery: 60-day IL (Elbow)

Expert's picks

With San Francisco's ace on the mound and Arizona struggling coming into this game, the visitors should be able to secure an important, hard-fought victory in Monday's game.

Money Line: San Francisco Giants -130

Run Line: Arizona +1.5 (-154)

Total Runs: Over 7.5 (-139)

About the author

Raghav Mehta is a baseball journalist at Sportskeeda awaiting results for a Bachelor's in Journalism from Delhi University. He enjoys highlighting the key battles between players at different stages of the game and analyzing the decisive moments upon which they hinge.

One of Raghav's favorite moments, which underscores this, was the Shohei Ohtani vs. Mike Trout clash in the 2023 WBC, where two of baseball's best players faced off against each other in the 9th inning. With the score 3-2 to Japan, Shohei eventually got the strikeout, which was absolute cinema.

Raghav is a Baltimore Orioles fan and is enjoying watching such an exciting young team compete at the top in a very competitive division.

Raghav has loved watching sports for as long as he can remember and realized he was pretty decent at writing his thoughts down at around the age of 14. Combining the two meant he had something he would enjoy doing every day, and he had identified that well before going to college.

Aside from work, Raghav enjoys playing sports, working out and watching movies.

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Edited by Victor R. Lopez M.

Giants vs. Diamondbacks: Game 1 prediction, odds, injuries, and picks - June 30, 2025