Today's Top MLB Pitchers Strikeouts Prop Bets: 5 picks including Tarik Skubal, Kodai Senga, and more for June 6, 2025

It’s one of those MLB slates where strikeout props steal the spotlight, and June 6, hands us a loaded board of arms built to miss bats. From Tarik Skubal’s relentless K streak to Kodai Senga’s pinpoint control in a dream matchup, today’s strikeout prop picks offer both high floors and ceiling-chasing value.

Sprinkle in Ben Brown’s sneaky upside, Sonny Gray’s consistency and Seth Lugo’s dependable line, and this card’s primed for a profitable ride.

Note: Odds are set by DraftKings Sportsbook and are subject to change. No outcome can be guaranteed when betting on sports.

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Today's Top Five MLB Pitchers Strikeouts Prop Bets

#5 Ben Brown (Cubs) - Over 5.5 Ks (-150)

Ben Brown might rack up over 6 K’s tonight - Source: Imagn

Brown might carry an ugly 5.72 ERA, but when it comes to strikeouts, the stuff is legit. The big righty’s racked up 71 punchouts in just 56.2 innings, boasting an elite 11.3 K/9.

He’s topped 5.5 Ks in four of his last five, including two electric 9-strikeout outings. Facing a Tigers offense that struggles against righties, Brown’s swing-and-miss upside makes this over a sharp, value-packed play tonight.

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#4 Sonny Gray (Cardinals) - Over 5.5 Ks (-130)

Sonny Gray might rack up over 6 K’s tonight - Source: Imagn

Gray has quietly been one of the steadiest strikeout arms this season, carrying a sharp 9.9 K/9 and an elite 1.8 BB/9 into this tough road matchup against the Dodgers.

Despite LA’s dangerous lineup, Gray’s recent form is undeniable, racking up double-digit strikeouts twice in his last five starts, including punch-out totals of 10, 5, 10, 4 and 8. With his swing-and-miss stuff dialed in, this over 5.5 line offers legit value even against a high-powered opponent.

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#3 Kodai Senga (Mets) - Over 6.5 Ks (-110)

Kodai Senga might rack up 7+ punchouts if he’s dialed in - Source: Imagn

Senga’s been pure dominance this season, flaunting a razor-sharp 1.60 ERA and holding hitters to just 0.4 HR/9. While his 8.6 K/9 isn’t elite tier, his filthy splitter keeps piling up whiffs when it matters.

Facing a Rockies lineup that struggles badly against quality pitchers, Senga’s in a perfect spot to attack this 6.5 strikeout line, especially with his recent run of sharp control and big-game consistency.

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#2 Seth Lugo (Royals) - Over 4.5 Ks (-160) Safest Pick of the Day

Seth Lugo is the safest pick of the day - Source: Imagn

Lugo isn’t known for gaudy strikeout numbers, but his consistency makes him a reliable prop target. The right-hander owns a 6.8 K/9 this season and has cashed the over 4.5 strikeouts line in four of his last six outings.

Against White Sox's patient but beatable matchup tonight, Lugo’s solid command gives this play sneaky value as the day’s safest option.

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#1 Tarik Skubal (Tigers) - Over 7.5 Ks (-105) Bold Prediction of the Day

Tarik Skubal is a bold prediction of the day - Source: Imagn

Tarik Skubal is making a Cy Young case with a ridiculous 2.26 ERA, an elite 0.79 WHIP and a nasty 11.8 K/9. The lefty’s been dialed in lately, racking up strikeouts in bunches, hitting at least 8 Ks in six of his last seven outings, including monster totals of 13, 12 and 11.

With that recent form and some of the sharpest command in the league (only seven walks in 75.2 innings), Skubal’s 7.5 line today feels built for a bold strikeout prop attack.