White Sox vs Astros: Game 2 prediction, odds, injuries, and picks

The AL West-leading Houston Astros take on the struggling Chicago White Sox on Wednesday for the second of three games set to take place at Daikin Park. The Astros are 36-30 for the season, while the White Sox are enduring another tough campaign and stand at 23-44 and fifth in the AL Central.

Let's take a look at the odds for Wednesday's fixture and how the action might play out on the field.

White Sox vs Astros prediction

Taking the mound for the White Sox is righty Sean Burke, who has been decent this year. At the moment, Burke is pitching with a 3-6 record, along with a 4.03 ERA and 50 total strikeouts.

Sean Burke in action for the Chicago White Sox - Source: Getty

With the bat, Miguel Vargas, Chase Meidroth, Andrew Benintendi and Luis Robert Jr. have been enjoying success off late for the visitors.

For Houston, Ryan Gusto makes his latest start. On paper, Gusto's campaign has been quite similar to that of his counterpart, with a 3-3 record, along with a 4.78 ERA and 45 total strikeouts.

Offensively, Jeremy Pena, Isaac Paredes, Jose Altuve and Jake Meyers have been leading the way for the hosts.

With the White Sox having recorded an unlikely upset in the series opener on Tuesday, the hosts will be motivated to hit back in Wednesday's fixture.

Prediction: Chicago White Sox 3, Houston Astros 6

Odds

Money Line: Chicago White Sox +140, Houston Astros -164

Run Line: White Sox +1.5 (-149), Houston -1.5 (+112)

Total Runs: Over 8.5 (-114), Under 8.5 (-116)

Injury report

White Sox injuries

Lenyn Sosa: 10-day IL (Hip)
Jonathan Cannon: 15-day IL (Back)
Tyler Gilbert: 15-day IL (Knee)
Jared Shuster: 15-day IL (Hand)
Miguel Castro: 60-day IL (Knee)
Martín Pérez: 60-day IL (Forearm)
Ky Bush: 60-day IL (Elbow)
Fraser Ellard: 60-day IL (Lat)
Prelander Berroa: 60-day IL (Elbow)
Drew Thorpe: 60-day IL (Elbow)
Jesse Scholtens: 60-day IL (Elbow)

Houston injuries:

Chas McCormick: 10-day IL (Oblique)
Zach Dezenzo: 10-day IL (Hand)
Taylor Trammell: 10-day IL (Calf)
Yordan Alvarez: 10-day IL (Hand)
Pedro Leon: 10-day IL (Knee)
Spencer Arrighetti: 15-day IL (Thumb)
Ronel Blanco: 60-day IL (Elbow)
J.P. France: 60-day IL (Shoulder)
Cristian Javier: 60-day IL (Elbow)
Hayden Wesneski: 60-day IL (Elbow)
Luis Garcia: 60-day IL (Elbow)

Expert's picks

With the pitching matchup relatively even, the host's superior offense should flex its muscles en route to a comfortable win on Wednesday, making up for Tuesday's upset in the process.

Money Line: Houston Astros -164

Run Line: Houston -1.5 (+112)

Total Runs: Over 8.5 (-114)

About the author

Raghav Mehta is a baseball journalist at Sportskeeda awaiting results for a Bachelor's in Journalism from Delhi University. He enjoys highlighting the key battles between players at different stages of the game and analyzing the decisive moments upon which they hinge.

One of Raghav's favorite moments, which underscores this, was the Shohei Ohtani vs. Mike Trout clash in the 2023 WBC, where two of baseball's best players faced off against each other in the 9th inning. With the score 3-2 to Japan, Shohei eventually got the strikeout, which was absolute cinema.

Raghav is a Baltimore Orioles fan and is enjoying watching such an exciting young team compete at the top in a very competitive division.

Raghav has loved watching sports for as long as he can remember and realized he was pretty decent at writing his thoughts down at around the age of 14. Combining the two meant he had something he would enjoy doing every day, and he had identified that well before going to college.

Aside from work, Raghav enjoys playing sports, working out and watching movies.

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Edited by John Maxwell

White Sox vs Astros: Game 2 prediction, odds, injuries, and picks - June 11, 2025