#3 Aaron Ramsey (Juventus) vs Miralem Pjanic (Barcelona)
Miralem Pjanic returns to the Allianz Stadium for the first time since leaving Juventus in August, but there will be no love lost on his welcome to Turin.
The Bosnian is still just adjusting to life with Barcelona, and Wednesday's clash will show how successful he's been so far when he duels with his former teammate Aaron Ramsey.
The Welshman is growing in confidence at Juventus. He has made his presence felt at both ends of the pitch, driving the ball forward to feed his attackers while also dropping back to provide an extra cover in defence when the Biaconeri are pushed on the backfoot.
With Ramsey playing right behind striker Alvaro Morata against Dynamo Kyiv, the former Arsenal man could don a similar role from the start if Cristiano Ronaldo is not deemed fit to play. If that happens, Ramsey would look to break through the lines and play defence-splitting passes for his Spanish colleague up front.
Pjanic could have a real task at hand against Ramsey when Barcelona face Juventus in Turin.
#2 Leonardo Bonucci (Juventus) vs Ansu Fati (Barcelona)
Fati may be just 17 years old but has given the meanest of defences in the competition a run for their money. His incisive runs behind the backline and lethal finishing have made him one of the best young strikers at the moment.
Even though Bonucci is twice Fati's age and possesses tremendous experience, he'll be unwise to underestimate Fati, who can wreak havoc if allowed space and time on the ball.
#1 Rodrigo Bentancur (Juventus) vs Lionel Messi (Barcelona)
So what if Cristiano Ronaldo doesn't play? Lionel Messi will still face significant competition from Juventus' midfield maestro Rodrigo Bentancur, who'll be tasked with stopping the Barcelona skipper in his tracks.
Due to the lack of a prolific creator at Barcelona, Messi often tends to drop deep these days, trying to win the ball back and spray passes forward or instigate attacks on the break.
However, Bentancur could stop that from happening by constantly pressing Messi on the ball or by using his strong frame to dispossess the diminutive Argentinian. Nevertheless, his duel with Messi could be one of the key player battles in the game.