In what turned out to be a night of upsets, top European clubs like Barcelona, Manchester City, Juventus and Bayern Munich endured unexpected defeats in their respective matches. Barcelona succumbed to a 1-0 defeat in their La Liga match against Rayo Vallecano, leaving them in 9th place on the league table after 10 matches. However, Real Madrid themselves were held to a 0-0 draw by Osasuna. As a result, the deficit between Barcelona and league leaders Real Madrid sits at just six points. The disappointing loss to Rayo Vallecano spelled the end of Ronald Koeman's time at the Catalan club after his sacking was announced shortly thereafter. Fabrizio Romano@FabrizioRomanoOFFICIAL. Ronald Koeman has been sacked. Barcelona are already looking for a new manager. 🔴🔵 #FCB #KoemanJoan Laporta decided after Wednesday night defeat vs Rayo.3:44 AM · Oct 28, 20216818411490OFFICIAL. Ronald Koeman has been sacked. Barcelona are already looking for a new manager. 🔴🔵 #FCB #KoemanJoan Laporta decided after Wednesday night defeat vs Rayo. https://t.co/dBYgkGczEYMeanwhile, Manchester City were shockingly dumped out of the Carabao Cup after losing to West Ham on penalties [0-0 (5-3)] in their Round 4 match. Having won the last four editions of the tournament, Pep Guardiola and co. will truly be disappointed by the fact that they now have one less trophy to compete for this season. Italian heavyweights Juventus continue to struggle this season as they fell to a 2-1 defeat at the hands of Sassuolo in Serie A last night. With ten league matches played so far, Juventus find themselves languishing in 7th place with 15 points to their name. 13 points separate them from current Serie A leaders AC Milan. Although just over a quarter of the competition has been completed, it already seems unlikely that Juventus will recover enough to challenge for the Scudetto this season. The most shocking result of the night came in the DFB-Pokal as Bayern Munich were thrashed 5-0 by Borussia Monchengladbach to get knocked out in round 2 of the competition. Despite fielding a full-strength side, the Bavarian giants were absolutely dismantled, with all five goals coming within the first 57 minutes of the game. George Addo Jnr@addojunrOne crazy ⚽️nightMan City,unbeaten in the CarabaoCup for 5 years- lose.Rayo Vallecano get their first victory vs Barcelona since 2002Sassuolo get their first Serie A win at Juve in their 9th attempt.Bayern lose by 5+ goals in the DFB-Pokal for the Ist time.Crazy!3:23 AM · Oct 28, 202114227One crazy ⚽️nightMan City,unbeaten in the CarabaoCup for 5 years- lose.Rayo Vallecano get their first victory vs Barcelona since 2002Sassuolo get their first Serie A win at Juve in their 9th attempt.Bayern lose by 5+ goals in the DFB-Pokal for the Ist time.Crazy! https://t.co/yiO6caoafWWhile the night of upsets prolonged the woes over at Barcelona and Juventus, it also means that Manchester City and Bayern Munich can no longer dream of winning the fabled European quadruple. It isn't often that these many European powerhouses suffer defeats on the same night, and Twitter was unsurprisingly set abuzz. Fans of these clubs as well as rival clubs from all around the world took to social media in order to express their thoughts. Without further ado, here is a look at some of the best reactions.Reactions to Rayo Vallecano 1-0 Barcelona🗣️🔴@afckataBarcelona with 0 shots on target vs Rayo Vallecano in 45 mins 😭😭😭11:17 AM · Oct 27, 20214Barcelona with 0 shots on target vs Rayo Vallecano in 45 mins 😭😭😭𝐀𝐅𝐂 𝐀𝐉𝐀𝐗 💎@TheEuropeanLadFT: Rayo Vallecano 1-0 Barcelona.Rayo Vallecano get their first victory vs Barcelona since 2002. Koeman faces his 5th defeat of the season, the same amount as victories.12:24 PM · Oct 28, 20211827133FT: Rayo Vallecano 1-0 Barcelona.Rayo Vallecano get their first victory vs Barcelona since 2002. Koeman faces his 5th defeat of the season, the same amount as victories. https://t.co/s7NuUqlBgjMαȥį Jҽɾʂҽყρʅυɠȥ@Chyma__People are bothered about a missed penalty equalizer when they should really be bothered about why fc Barcelona the great need a penalty to EQUALIZE and take a draw from a match vs rayo vallecano??!!!! 😂😂😂💀💀💀 twitter.com/brfootball/sta…B/R Football@brfootballMemphis Depay missed the equalizer for Barcelona from the spot 😳1:37 AM · Oct 28, 20219433505Memphis Depay missed the equalizer for Barcelona from the spot 😳 https://t.co/P5v46nDFIWPeople are bothered about a missed penalty equalizer when they should really be bothered about why fc Barcelona the great need a penalty to EQUALIZE and take a draw from a match vs rayo vallecano??!!!! 😂😂😂💀💀💀 twitter.com/brfootball/sta…Madrid Zone@theMadribZoneSomebody write an apology letter to valverde and bring him back11:25 AM · Oct 27, 2021294Somebody write an apology letter to valverde and bring him backDilax@LeoPeak10I want to apoligize for comparing Depay to Benzema in begin of the season. Benzema is much better and he is the face of La Liga.12:25 PM · Oct 28, 2021121575I want to apoligize for comparing Depay to Benzema in begin of the season. Benzema is much better and he is the face of La Liga.Josip@JosipFCB93Messi was covering all the cracks by himself and now he's gone. That's what happened. There is no bigger proof that Messi needs to win Ballon d'Or than watching this team play without him. twitter.com/brilliantbusi/…★@brilliantbusiLast season we actually become good at a certain point. We thought we could even win the league. It all went downhill since then. What exactly happened?12:42 PM · Oct 28, 202122435Last season we actually become good at a certain point. We thought we could even win the league. It all went downhill since then. What exactly happened?Messi was covering all the cracks by himself and now he's gone. That's what happened. There is no bigger proof that Messi needs to win Ballon d'Or than watching this team play without him. twitter.com/brilliantbusi/…Barça Universal@BarcaUniversalBarça have not won a single away match this season. Not in La Liga nor the Champions League.12:26 PM · Oct 28, 20213106236Barça have not won a single away match this season. Not in La Liga nor the Champions League. https://t.co/Or17LXujiY•@The_Gerrard_EraThe fact that Messi won the Cup and almost La Liga with Koeman in charge while having 50 g/a might be his biggest achievement in career12:25 PM · Oct 28, 202135732The fact that Messi won the Cup and almost La Liga with Koeman in charge while having 50 g/a might be his biggest achievement in careerLulzFCB@lulzfcbBarcelona fans disrespected Luis Suarez. Hence they deserve bums like Depay and Luuk de Jong. Enjoy struggling vs Rayo 🤣🤣🤣12:21 PM · Oct 28, 2021705Barcelona fans disrespected Luis Suarez. Hence they deserve bums like Depay and Luuk de Jong. Enjoy struggling vs Rayo 🤣🤣🤣Reactions to West Ham 0-0 (5-3 Penalties) Manchester City 𝓛𝓮𝓮🍊@IeeSZNit’s going to look so weird watching another team lift the Carabao Cup 😭2:21 AM · Oct 28, 202192617it’s going to look so weird watching another team lift the Carabao Cup 😭⭐⭐@RonyMayodiManchester City are out of their own cup.. Hahahahaa9:19 AM · Oct 28, 2021Manchester City are out of their own cup.. Hahahahaatremnineone ⭐⭐@CFCtremnineoneWOKE UP TO FIND MANCHESTER CITY ARE OUT OF THE ONLY COMPETITION THEY WERE GOING TO WIN THIS SEASON 😭😭😭AHAHAHAHAHHAHAHAHAH8:55 AM · Oct 28, 20213WOKE UP TO FIND MANCHESTER CITY ARE OUT OF THE ONLY COMPETITION THEY WERE GOING TO WIN THIS SEASON 😭😭😭AHAHAHAHAHHAHAHAHAHVaishach@VaishachWhy isn’t Manchester City losing to West Ham B team , not been talked enough?8:19 AM · Oct 28, 2021Why isn’t Manchester City losing to West Ham B team , not been talked enough?Murtaza Ehsan@MurtazaEhsan3Still can’t believe Manchester City has never lost a tie in the EFL cup for 5 years And they’ve lost to West Ham on penalties7:20 AM · Oct 28, 2021Still can’t believe Manchester City has never lost a tie in the EFL cup for 5 years And they’ve lost to West Ham on penaltiesReactions to Juventus 1-2 SassuoloMartin Tan@MartinTan1Only way for Juventus to recuperate is that Allegri pulling off a 15 game win streak #Juventus #SerieA #JuventusSassuolo8:51 AM · Oct 28, 2021Only way for Juventus to recuperate is that Allegri pulling off a 15 game win streak #Juventus #SerieA #JuventusSassuoloJay Hass@JayHass21@juvefcdotcom Goal Differential is the most telling stat in that table. Juventus cannot score. You have to score to win. You have to win the compete for the league title.8:25 AM · Oct 28, 2021@juvefcdotcom Goal Differential is the most telling stat in that table. Juventus cannot score. You have to score to win. You have to win the compete for the league title.Jaka🇦🇿@not__jakaJuventus has top 5 lowest IQ fan bases I have never seen so many horrible opinions9:07 AM · Oct 28, 20214Juventus has top 5 lowest IQ fan bases I have never seen so many horrible opinions𝔄𝔫𝔡𝔯𝔦𝔢 𝔑𝔞𝔷𝔱𝔦𝔢@andrienazthie@SiaranBolaLive Retweet to scare Juventus fansSIUUUUUUUUUUUU7:32 AM · Oct 28, 2021112@SiaranBolaLive Retweet to scare Juventus fansSIUUUUUUUUUUUU https://t.co/r1ywKXdifzMarco Bertazzoni@kingodreams@Juventus is missing @Cristiano7:12 AM · Oct 28, 2021@Juventus is missing @CristianoAlemax@Alemax28536943@juventusfc There is now way juve will win champions league with alegri!! The way they play it just to complicated!7:10 AM · Oct 28, 2021@juventusfc There is now way juve will win champions league with alegri!! The way they play it just to complicated!CrunchM@monster1538@graniro_r @TrollFootball juventus are going to serie b6:35 AM · Oct 28, 2021@graniro_r @TrollFootball juventus are going to serie bReactions to Borussia Monchengladbach 5-0 Bayern MunichBayern & Germany@iMiaSanMiaBayern have suffered their biggest defeat in DFB Pokal history [Opta]2:13 AM · Oct 28, 2021117893Bayern have suffered their biggest defeat in DFB Pokal history [Opta]EiF@EiFSoccerCan’t believe that Bayern losing 5-0 to Borussia Monchengladbach is going under the radar.And yes, Bayern are completely full strength. Absolute madness!1:57 AM · Oct 28, 202132139Can’t believe that Bayern losing 5-0 to Borussia Monchengladbach is going under the radar.And yes, Bayern are completely full strength. Absolute madness!LM7⚡️@Silverfutbal@FCBayernEN Bayern fans are celebrating because now they can bring up this result and say Bundesliga is competitive 😭1:35 AM · Oct 28, 202153738@FCBayernEN Bayern fans are celebrating because now they can bring up this result and say Bundesliga is competitive 😭Markfcb@markkfcb_Ronaldo and Lewandowski both loosing 5-0 in the same week😳2:36 AM · Oct 28, 2021131Ronaldo and Lewandowski both loosing 5-0 in the same week😳Bayern & Germany@iMiaSanMiaBayern have failed to score for the first time in 84 competitive games (February 2020 against Leipzig)2:10 AM · Oct 28, 20211451187Bayern have failed to score for the first time in 84 competitive games (February 2020 against Leipzig)Madrid Zone@theMadribZoneIf Messi was 5-0 down ahead of ballon dor ceremony, whole Ronaldo FC would have started their agenda against Messi and Ballon dor. Since its Lewandowski now, it doesn’t suits their agenda.1:38 AM · Oct 28, 202116033If Messi was 5-0 down ahead of ballon dor ceremony, whole Ronaldo FC would have started their agenda against Messi and Ballon dor. Since its Lewandowski now, it doesn’t suits their agenda.