The ABC soap opera General Hospital first premiered on April 1, 1963, and has since become a key part of American daytime television. The show is set in the fictional town of Port Charles and deals with the lives of the town's most powerful families, such as the Corinthos and Quartermaines.Even since the show's inception, the Corinthos family has been a central part of the show's storyline because of their control and grip over Port Charles. The family is known for its mob ties and its involvement in organized crime. Some of the key members of the family include Sonny Corinthos, Carly Spencer, Dante Falconeri, and Lulu Spencer.Apart from the Corinthos family, the Quartermaine family has also been involved in the major story arcs on General Hospital. The Quartermaines are a very wealthy and prestigious family on the ABC daytime drama. They have been entangled in crucial storylines since their introduction in the late 1970s. Alan and Monica Quartermaine, Jason Morgan, Elizabeth Webber, Nikolas, and Emily Quartermaine are part of this family.General Hospital also deals with a few other families, namely the Spencer family, the Cassadine family, the Webber family, and the Scorpio family. Members of these families have been involved in the drama, power struggles, and romance in Port Charles throughout several generations.Family tree of the residents of Port Charles on General HospitalThe Corinthos family tree on General Hospital View this post on Instagram Instagram PostFirst generation of the Cornithos family on General Hospital Michael "Mike" Corbin - Father of Sonny CorinthosAdele Corinthos - Mother of Sonny CorinthosSecond generationMichael "Sonny" Corinthos - Corinthos family patriarchCourtney Matthews - Daughter of Mike Corbin and Janine MatthewsBrando CorbinThird generationDante Falconei - Son of mob boss Sonny Corinthos and Olivia QuartermaineMichael Corinthos III - Son of A. J. Quartermaine and Carly Corinthos, and the adoptive son of mob boss Sonny CorinthosKristina Davis - Daughter of Alexis Davis and Sonny CorinthosMorgan Corinthos - First biological child of Sonny and Carly CorinthosAvery Corinthos - Daughter of Sonny Corinthos and Ava JeromeLila McCall - Daughter of mob boss Sonny Corinthos and his late ex-mistress, Sam McCallDonna Corinthos - Daughter of Sonny Corinthos and Carly SpencerEmily Matthews-Morgan - The Late daughter of former mob enforcer Jason Morgan and his ex-wife, the late Courtney MatthewsSpencer Casadine - Son of Nikolas Cassadine and the late Courtney MatthewsLiam Corbin - Son of the late Brando Corbin and Sasha GilmoreFourth generationGiovanni "Gio" Palmieri - Biological son of Brook Lynn Quartermaine and Dante Falconeri, and the adoptive son of the late Francis and Camila PalmieriRocco Falconeri - Son of Dante and LuluWiley Corinthos - Son of Michael Corinthos and the late Nelle Benson, and adoptive son of Michael's wife, Willow TaitAmelia Corinthos - Daughter of Michael Corinthos and Willow Tait-CorinthosDaisy Corinthos - Daughter of Michael Corinthos and his ex-fiancée, Sasha GilmoreIrene Davis-Ashford - Daughter of domestic partners Dr. T.J. Ashford and Molly Lansing-Davis, through surrogate and egg donor Kristina Corinthos-DavisThe Quartermaine family tree on General Hospital View this post on Instagram Instagram PostFirst generation of the Quartermaine family on General HospitalEdward Quartermaine - Son of George and IdaLila Morgan - Daughter of Harold, sister of Hal, Edward's wifeHerbert Quartermaine - Edward's first cousin, father of QuentinUnnamed Male - Edward's brother, son of George and IdaHal Morgan - Brother of Lila, son of HaroldSecond generationBradley Ward - Son of Edward and Mary Mae Ward, raised by Dan WardIsobel Ward - Bradley's widowAlan Quartermaine, Sr. - Son of Edward and LilaMonica Bard - Alan's widowTracy Quartermaine - Daughter of Edward and LilaJimmy Lee Holt - Son of Edward and Beatrice LeSeurCharity GatlinQuentin Quartermaine - Son of HerbertBetsy QuartermaineAlexandria "Alex" Quartermaine - Edward's nieceThird generationAntoinette "Skye" Chandler Quartermaine - Adoptive daughter of Alan, biological daughter of Rae CummingsAlan "A.J." Quartermaine, Jr. - Son of Alan and MonicaJason Morgan - Son of Alan and Susan Moore, adopted by MonicaAndrew "Drew" Cain - Son of Alan and Susan Moore, taken at birth by Heather Webber and given to Betsy FrankEmily Quartermaine - Adopted daughter of Alan and Monica, engaged to Nikolas Cassadine at the time of her deathEdward "Ned" Quartermaine - Son of Tracy and Larry AshtonOlivia FalconeriDillon Quartermaine - Son of Tracy and Paul HornsbyCelia Quartermaine - Quentin's daughter with his first wifeJustus Ward - Son of Bradley and IsobelFaith Ward - Daughter of Bradley and IsobelAustin Gatlin-Holt - Son of Jimmy and CharityFourth generationMaya Ward - Daughter of FaithBrook Lynn Quartermaine - Daughter of Ned and Lois CerulloHarrison ChaseMichael Corinthos III - Son of A.J. and Carly Benson, adopted by Sonny CorinthosLila Rae Alcazar - Daughter of Skye and Lorenzo AlcazarJacob "Jake" Webber - Son of Jason and Elizabeth WebberDaniel "Danny" Morgan - Son of Jason and Sam McCallEmily "Scout" Quartermaine - Daughter of Drew and Sam McCallOscar Nero-Quartermaine - Son of Drew and Kim NeroLeo Quartermaine - Son of Ned (adopted) and OliviaFifth generationGiovanni "Gio" Palmieri - Brook Lynn's son with Dante FalconeriWiley Corinthos - Son of Michael and Nelle Benson, adopted by WillowAmelia Corinthos - Daughter of Michael and Willow TaitDaisy Gilmore-Corinthos - Daughter of Michael and Sasha GilmoreAlso Read: General Hospital spoiler video sneak peek (June 26, 2025): Lulu guides Cody, Sasha issues a demand, and Sidwell delivers a clear threatFans of General Hospital can watch new episodes of the show on ABC and Hulu.