The Twisted Tale of Amanda Knox season 1 episode 6 premiered on September 17, 2025, exclusively on Hulu. This episode comes after Amanda's worst and most life-changing experiences in the Italian prison system.
Picking up where the last episode left off with the guilty verdict, this one looks at the mental toll of being wrongfully convicted. It shows how Amanda goes back and forth between despair and strength as her appeal trial starts to take shape.
Disclaimer: The following article contains spoilers from The Twisted Tale of Amanda Knox season 1 episode 6. Reader’s discretion is required.
Titled, Colpevole, the episode goes deep into Amanda's mental struggle and the legal chess game that is coming up. This is where Amanda's inner battle is like the one outside: a young woman trying to get her sense of self back while facing a life sentence for a crime she didn't commit.
The ending shows that Amanda's strength comes back because she won't let the prosecution change her story. Instead, she gets her hope back with the help of friends and family like Don Saulo, Cecilia, and her family.
The last scene of The Twisted Tale of Amanda Knox season 1 episode 6 leaves the audience with a question of how someone gets ready for freedom when they have learned to live in prison. Amanda's quiet night with Don Saulo, when they sang about freedom, ends with a cliffhanger just before the verdict.
The Twisted Tale of Amanda Knox Season 1 Episode 6: What drives Amanda to reclaim her strength?

The Twisted Tale of Amanda Knox season 1 episode 6 focuses on Amanda's journey to becoming stronger after a dark time. She was upset and thought about killing herself. Amanda first becomes very depressed after hearing her terrible guilty verdict and spending months in jail. She feels lost, alone, and broken because of the weight of a life sentence.
But things start to change when Amanda's cellmate is Cecilia, another American prisoner. Cecilia not only reads letters that support Amanda, but she also helps Amanda find her sense of purpose again. As the months go by, Amanda starts doing yoga, teaching it to other prisoners, and focusing on the little things that make her happy in prison.
How does Amanda’s breakthrough moment occur?

Amanda changes after getting a letter from Saul, who knows a lot about how to question people. Saul writes in the letter about the sneaky ways police often use to break down suspects. With this, Amanda immediately feels connected because she remembers being forced to lie during her interrogation.
A key moment is when she realized that what she had been through wasn't an isolated incident but rather a planned strategy used against her. Amanda shows Chris, her stepfather, the letter.
Chris tells her that she couldn't have known how to handle such intense pressure at age 20. This new information gives Amanda hope and makes her more determined than ever. For the first time, she feels like she is truly understood and accepted.
How does Amanda prepare for her appeal trial?

Amanda takes charge of her fate with newfound strength. She asks the judge to review every prosecution detail that implicated her. This change from passivity to action changes her story.
Amanda speaks clearly and confidently, no longer frightened like she was. The defense presents two independent DNA experts who disprove the prosecution in court. They found a knife, tested with 50 other items and a bra clasp that was contaminated due to careless handling.
What happens in Amanda’s final moments before the verdict?

As the episode goes on, Amanda's emotional journey comes to a quiet but moving end right before the verdict. She sits with Don Saulo and thinks about the life she used to have and the uncertain future she has ahead of her. Her mind is at ease with the thought of spending years in jail, but she still doesn't know what she will do if she gets out.
Don Saulo gives her a cross, the sign of strength, resilience, and freedom. Amanda sings a final song on the piano, her voice filled with emotion and the longing for freedom she has carried for so long.
By the end, the prison phone rings, letting everyone know that the verdict is in. The longing look on Amanda's face shows the uncertainty she feels inside. This fight is not only for freedom but also for the chance to live without the weight of false accusations.
The Twisted Tale of Amanda Knox season 1 episode 6 is available to stream on Hulu.