#5 Seth Rollins nailed Randy Orton with an RKO at WWE Extreme Rules 2015

The RKO is one of the most destructive finishers in all of WWE. Randy Orton has won nearly all of his championships in WWE by hitting the maneuver perfectly.
However, at Extreme Rules 2015, the RKO ended up costing Orton a WWE Championship opportunity. The Viper took on Seth Rollins who was holding the title at the time, in a Steel Cage match.
At a time when it looked like Orton would defeat Rollins to win the title, The Architect nailed Orton with an RKO out of nowhere. The move was enough to keep Orton down while Rollins escaped the cage to win the match and retain his title.
#4 Brock Lesnar made Kurt Angle tap out on WWE SmackDown.

Kurt Angle is widely regarded as one of the best and toughest WWE Superstars of all time. Angle won several top titles during his lengthy career and took on the biggest stars in the industry.
During his time in the ring, Angle used the Ankle Lock to win many of his matches. Ken Shamrock made the submission move popular, and Angle used it generously during his matches.
However, the same move came back to haunt him during an episode of WWE SmackDown in September 2003. Angle faced Brock Lesnar in a WWE Championship Iron Man match on the show.
The Beast used the Ankle Lock against Angle to pick up one of the five falls that helped him win the match. This wasn’t the only time that the Ankle Lock cost The Olympic Gold Medalist a match in WWE.