WWE Elimination Chamber 2021 was held at the WWE Thunderdome at Tropicana Field in St. Petersburg, Florida.
| No. | Matches | Stipulations | Results |
| 1. | Kevin Owens, Daniel Bryan, Cesaro, Jey Uso, Sami Zayn and King Corbin | SmackDown Elimination Chamber Match | Daniel Bryan def. the Elimination Chamber and will face Roman Reigns for the Universal Championship |
| 2. | Roman Reigns (c) vs. Daniel Bryan | Universal Championship Match | Roman Reigns def. Daniel Bryan to retain Universal Championship |
| 3. | Bobby Lashley (c) vs. Riddle vs. John Morrison | United States Championship Match | Riddle def. John Morrison & Bobby Lashley to become the new United States Champion |
| 4. | Sasha Banks & Bianca Belair vs Nia Jax & Shayna Baszler (c) | WWE Women’s Tag Team Championship Match | Nia Jax & Shayna Baszler def. Sasha Banks & Bianca Belair to retain the Women's Tag Team Titles |
| 5. | Drew McIntyre, Randy Orton, Jeff Hardy, AJ Styles, The Miz and Sheamus | WWE Champion Elimination Chamber Match | Drew McIntyre won the Elimination Chamber match and retained the WWE Championship. |
| 6. | The Miz vs. Drew McIntyre (c) | WWE Champion Match (Money in the Bank Contract Cashed in by the Miz) | The Miz def. Drew McIntyre to become the new WWE Champion |
This year's WWE Elimination Chamber PPV was broadcasted from the WWE ThunderDome in Tropicana Field, St. Petersburg, Florida, United States.
The main Elimination Chamber event started at 7PM EST/ 4PM PST on Sunday, February 21st.
| Event | Date | City | Venue | Main Event |
| Elimination Chamber (2010) | 21/02/2010 | St. Louis, Missouri | Scottrade Center | The Undertaker (c) vs. Chris Jericho, vs. R-Truth vs. John Morrison vs. Rey Mysterio vs.CM Punk in an Elimination Chamber match for the World Heavyweight Championship |
| Elimination Chamber (2011) | 20/02/2011 | Oakland, California | Oracle Arena | John Cena vs. Randy Orton vs Sheamus vs. CM Punk vs. John Morrison vs. R-Truth in an Elimination Chamber match for a WWE Championship match at WrestleMania XXVII |
| Elimination Chamber (2012) | 19/02/2012 | Milwaukee, Wisconsin | Bradley Center | John Cena vs. Kane in an Ambulance match |
| Elimination Chamber (2013) | 17/02/2013 | New Orleans, Louisiana | New Orleans Arena | The Rock (c) vs. CM Punk for the WWE Championship |
| Elimination Chamber (2014) | 23/02/2014 | Minneapolis, Minnesota | Target Center | Randy Orton (c) vs. John Cena vs. Sheamus vs. Daniel Bryan vs. Cesaro vs. Christian in an Elimination Chamber match for the WWE World Heavyweight Championship |
| Elimination Chamber (2015) | 31/05/2015 | Corpus Christi, Texas | American Bank Center | Seth Rollins (c) vs. Dean Ambrose for the WWE World Heavyweight Championship |
| Elimination Chamber (2017) | 12/02/2017 | Phoenix, Arizona | Talking Stick Resort Arena | John Cena (c) vs. AJ Styles vs. Dean Ambrose vs. The Miz vs. Baron Corbin vs. Bray Wyatt in an Elimination Chamber match for the WWE Championship |
| Elimination Chamber (2018) | 25/02/2018 | Paradise, Nevada | T-Mobile Arena | Braun Strowman vs. Elias vs. Finn Bálor vs. John Cena vs. Roman Reigns vs. Seth Rollins vs. The Miz in an Elimination Chamber match for a WWE Universal Championship match at WrestleMania 34 |
| Elimination Chamber (2019) | 17/02/2019 | Houston, Texas | Toyota Center | Daniel Bryan(c) vs. Jeff Hardy vs. Kofi Kingston vs. Randy Orton vs. AJ Styles vs. Samoa Joe for the WWE Championship |
| Elimination Chamber (2020) | 08/03/2020 | Philadelphia, Pennsylvania | Wells Fargo Center | Natalya vs. Liv Morgan vs. Shayna Baszler vs. Asuka vs. Ruby Riott vs. Sarah Logan |
| Elimination Chamber (2021) | 21/02/2021 | St. Petersburg, Florida | WWE ThunderDome | Drew McIntyre, Randy Orton, Jeff Hardy, AJ Styles, The Miz and Sheamus for WWE Champion |
