Astros vs Red Sox: Game 3, prediction, odds, injuries and picks

The Houston Astros lock horns with the Boston Red Sox on Wednesday for the final game of the series at Daikin Park. Coming into this fixture, Houston is tied for first place in the AL West with a 67-53 record, while Boston, currently 66-55, occupies second place in the AL East.

Let's take a look at the odds to get an idea of how the action might play out in Wednesday's series finale.

Astros vs Red Sox prediction

Taking the mound for the Astros is All-Star Hunter Brown, who has been excellent this season, boasting a 9-5 record, along with a 2.51 ERA and 160 strikeouts.

Hunter Brown in action against the New York Yankees - Source: Getty

At the plate, Jose Altuve, Jeremy Pena, Yainer Diaz and Christian Walker have been enjoying success of late for the hosts.

For Boston, veteran Walker Buehler takes the mound. Having made the move to Fenway Park in the offseason, Buehler has struggled with his new team (7-6 record, along with a 5.40 ERA and 75 strikeouts).

Offensively, the likes of Alex Bregman, Trevor Story, Jarren Duran and Roman Anthony are the key players for the visitors.

Coming into Wednesday's rubber game with a dominant 14-1 win in Tuesday's fixture, Boston should be able to carry on in the same vein and register another important win.

Prediction: Houston Astros 4, Boston Red Sox 5

Odds

Money Line: Houston Astros -167, Boston Red Sox +141

Run Line: Houston -1.5 (+113), Boston +1.5 (-139)

Total Runs: Over 7.5 (-130), Under 7.5 (+107)

Injury report

Astros injuries:

Jake Meyers: 10-day IL (Calf)
Lance McCullers: 15-day IL (Finger)
Brandon Walter: 15-day IL (Elbow)
Josh Hader: 15-day IL (Shoulder)
Ronel Blanco: 60-day IL (Elbow)
J.P. France: 60-day IL (Shoulder)
Zach Dezenzo: 60-day IL (Hand)
Brendan Rodgers: 60-day IL (Oblique)
Isaac Paredes: 60-day IL (Hamstring)
Hayden Wesneski: 60-day IL (Elbow)
Yordan Alvarez: 60-day IL (Hand)
Luis Garcia: 60-day IL (Elbow)
Pedro Leon: 60-day IL (Knee)

Red Sox injuries:

Marcelo Mayer: 10-day IL (Wrist)
Triston Casas: 60-day IL (Knee)
Justin Slaten: 60-day IL (Shoulder)
Josh Winckowski: 60-day IL (Elbow)
Luis Guerrero: 60-day IL (Elbow)
Kutter Crawford: 60-day IL (Knee)
Patrick Sandoval: 60-day IL (Elbow)
Liam Hendriks: 60-day IL (Hip)
Tanner Houck: 60-day IL (Flexor)
Hunter Dobbins: 60-day IL (Acl)

Expert's picks

Houston has been a bit inconsistent of late, which has seen them drop in the AL West standings. On the other hand, Boston has been one of the hottest teams in the majors since the All-Star break.

The visitors' exciting offense, which dominated on Tuesday, should see the Red Sox over the line in Wednesday's fixture, helping them clinch the series in the process.

Money Line: Boston Red Sox +141

Run Line: Boston +1.5 (-139)

Total Runs: Over 7.5 (-130)

About the author

Raghav Mehta is a baseball journalist at Sportskeeda awaiting results for a Bachelor's in Journalism from Delhi University. He enjoys highlighting the key battles between players at different stages of the game and analyzing the decisive moments upon which they hinge.

One of Raghav's favorite moments, which underscores this, was the Shohei Ohtani vs. Mike Trout clash in the 2023 WBC, where two of baseball's best players faced off against each other in the 9th inning. With the score 3-2 to Japan, Shohei eventually got the strikeout, which was absolute cinema.

Raghav is a Baltimore Orioles fan and is enjoying watching such an exciting young team compete at the top in a very competitive division.

Raghav has loved watching sports for as long as he can remember and realized he was pretty decent at writing his thoughts down at around the age of 14. Combining the two meant he had something he would enjoy doing every day, and he had identified that well before going to college.

Aside from work, Raghav enjoys playing sports, working out and watching movies.

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Edited by Krutik Jain

Astros vs Red Sox: Game 3, prediction, odds, injuries and picks - August 13, MLB 2025