Diamondbacks vs. Giants: Game 4 prediction, lineup, odds, injuries and picks

The Arizona Diamondbacks take on the San Francisco Giants on Thursday for the fourth and final game of the series at Chase Field. Coming into this game, the Arizona Diamondbacks are fourth in the NL West, with a 43-43 record, while San Francisco is a spot above them with a 46-41 record.

Let's take a look at the odds and how the action might play out in Thursday's series finale.

Diamondbacks vs Giants prediction

Taking the mound for the hosts is righty Brandon Pfaadt, who has struggled this season. At the moment, Pfaadt is pitching with an 8-5 record, along with a 5.38 ERA and 72 strikeouts.

Brandon Pfaadt in action against the Miami Marlins - Source: Getty

At the plate, the likes of Geraldo Perdomo, Ketel Marte, Eugenio Suarez and Josh Naylor have enjoyed strong seasons for Arizona.

Starting for San Francisco is lefty Robbie Ray, who has fared much better than his counterpart on paper, boasting an 8-3 record, along with a 2.75 ERA and 110 strikeouts for the year.

Offensively, Rafael Devers, Heliot Ramos, Jung Hoo Lee and Mike Yastrzemski have impressed for the visitors of late.

Coming into this game with a morale-boosting victory after extra innings on Wednesday, San Francisco should be able to carry that momentum forward and leave Phoenix with a split series.

Prediction: Arizona Diamondbacks 4, San Francisco Giants 5

Odds

Money Line: Arizona Diamondbacks +102, San Francisco Giants -120

Run Line: Arizona +1.5 (-161), San Francisco -1.5 (+131)

Total Runs: Over 7.5 (-147), Under 7.5 (+119)

Injury report

Diamondbacks injuries

Gabriel Moreno: 10-day IL (Hand)
Ildemaro Vargas: 10-day IL (Foot)
Corbin Carroll: 10-day IL (Hand)
Kendall Graveman: 15-day IL (Hip)
Blake Walston: 60-day IL (Elbow)
Corbin Burnes: 60-day IL (Elbow)
A.J. Puk: 60-day IL (Elbow)
Christian Montes De Oca: 60-day IL (Elbow)
Cristian Mena: 60-day IL (Shoulder)
Justin Martinez: 60-day IL (Elbow)
Jordan Montgomery: 60-day IL (Elbow)
Josh Naylor: day-to-day (Undisclosed)

Giants injuries

Casey Schmitt: 10-day IL (Hand)
Christian Koss: 10-day IL (Hamstring)
Matt Chapman: 10-day IL (Hand)
Jerar Encarnación: 10-day IL (Oblique)
Tom Murphy: 60-day IL (Back)

Expert's picks

With the pitching matchup clearly favoring San Francisco in this game, the eight-time World Series winners should be able to pick up an important, hard-fought victory in Thursday's series finale, splitting the series at two games apiece.

Money Line: San Francisco Giants -120

Run Line: Arizona +1.5 (-161)

Total Runs: Over 7.5 (-147)

About the author

Raghav Mehta is a baseball journalist at Sportskeeda awaiting results for a Bachelor's in Journalism from Delhi University. He enjoys highlighting the key battles between players at different stages of the game and analyzing the decisive moments upon which they hinge.

One of Raghav's favorite moments, which underscores this, was the Shohei Ohtani vs. Mike Trout clash in the 2023 WBC, where two of baseball's best players faced off against each other in the 9th inning. With the score 3-2 to Japan, Shohei eventually got the strikeout, which was absolute cinema.

Raghav is a Baltimore Orioles fan and is enjoying watching such an exciting young team compete at the top in a very competitive division.

Raghav has loved watching sports for as long as he can remember and realized he was pretty decent at writing his thoughts down at around the age of 14. Combining the two meant he had something he would enjoy doing every day, and he had identified that well before going to college.

Aside from work, Raghav enjoys playing sports, working out and watching movies.

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Edited by Ribin Peter

Diamondbacks vs. Giants: Game 4 prediction, lineup, odds, injuries and picks - July 3, 2025