Best NFL DFS Picks for Philadelphia Eagles vs. Indianapolis Colts

The Philadelphia Eagles look to get back on track following their first loss. The Indianapolis Colts look to keep the positive momentum going with their new head coach Jeff Saturday.

Today we look at the best DFS plays from this intriguing match-up.

Best quarterback picks

Cash Games: Jalen Hurts, QB, Philadelphia Eagles (DraftKings $8.2K, FanDuel $8.8K)

Jalen Hurts remains one of the safest bets in all of fantasy football. Even when Hurts and the Eagles' offense didn't have their 'A' game on Monday Night Football, he remained highly productive through the air and on the ground.

Tournaments: Matt Ryan, QB, Atlanta Falcons (Draftkings $5.2K, FanDuel $7.1K)

Matt Ryan returned to the Colts' starting lineup, and wouldn't you know it, the Colts were victorious! The Colts' offense is more consistent with Matty Ice under center.

$1,000 No Sweat First Bet with FanDuel Sportsbook

Best running back picks

Cash Games: Jonathan Taylor, RB, Indianapolis Colts (DraftKings $7.8K, FanDuel $8.7K)

Jonathan Taylor will be one of the most popular plays on the slate, regardless of position. We saw the explosive version of Taylor last week, which we came to expect every week a year ago.

The Eagles' defense has been run all over since the Jordan Davis injury. The Colts are at home, a prime spot for 20+ touches for Taylor.

Tournament: Miles Sanders, RB, Philadelphia Eagles (DraftKings $6.9K, FanDuel $7.3K)

The Eagles would be wise to return to their ground game in this one. They got away from the run on Monday Night Football, much to their detriment. A more balanced approach will benefit Miles Sanders and the team.

Wide receivers and tight ends

Cash game: A.J. Brown, WR, Philadelphia Eagles (DraftKings $8K, FanDuel $8.4K)

Keep an eye on the injury report leading up to this one. A.J. Brown says he is fine, but he tweaked his ankle early in the Washington game and didn't seem to be his usual explosive self throughout the remainder of the contest. If Brown practices fully, fire him up in a bounce-back spot.

Tournament: Michael Pittman Jr., WR, Indianapolis Colts (DraftKings $6.1K, FanDuel $6.7K)

The Eagles secondary has been spectacular for most of the 2022 season, but we saw some concerning signs on Monday Night Football.

The pressure up front wasn't great, allowing Taylor Heinicke to find Terry McLaurin early and often. Michael Pittman Jr. could see plenty of targets in this one.