The Apothecary Diaries season 2 episode 22 release date and time, where to watch, and more

The Apothecary Diaries season 2 episode 22 will arrive with devastating consequences as Maomao confronts the horrifying aftermath of Loulan's desperate actions in the stronghold's upper chambers.

The episode is set to air on Friday, June 13, 2025, at 11:40 pm JST on Nippon TV, with international streaming on Crunchyroll shortly after. It will explore the psychological toll of war as the imperial army closes in on Minister Shishou's rebellion.

With Kyou-u and innocent children poisoned by Loulan's twisted version of mercy, The Apothecary Diaries season 2 episode 22 promises to deliver heart-wrenching drama. It will further test Maomao's resolve in an increasingly dangerous situation.

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The Apothecary Diaries season 2 episode 22: Release date and time for all major regions

The Apothecary Diaries season 2 episode 22 premieres on June 13, 2025, at 11:40 pm JST. The scheduled release time is specific for Japanese audiences, while other regions will have different release times. According to different time zones, the schedule is as follows:

Time Zone	Release Day	Release Date	Release Time
Pacific Time	Friday	June 13, 2025	6:40 am
Eastern Time	Friday	June 13, 2025	9:40 am
Greenwich Mean Time	Friday	June 13, 2025	2:40 pm
Central European Time	Friday	June 13, 2025	3:40 pm
Indian Standard Time	Friday	June 13, 2025	8:10 pm
Philippine Time	Friday	June 13, 2025	10:40 pm
Japanese Standard Time	Friday	June 13, 2025	11:40 pm
Australian Central Time	Saturday	June 14, 2025	1:10 am

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Where to watch The Apothecary Diaries season 2 episode 22?

For the Japanese audience, The Apothecary Diaries season 2 episode 22 will air on local TV channels such as Nippon Television, AT-X, Movie Channel Neco, and Animax. Each channel will broadcast the episode at its local time. The series is also available on Japanese streaming sites like ABEMA Premium, Anime Store, and others.

For global fans, The Apothecary Diaries season 2 episode 22 will be available on Crunchyroll approximately two and a half hours after its broadcast in Japan. The series is also available on Netflix, though a subscription is required.

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The Apothecary Diaries season 2 episode 21 recap

In The Apothecary Diaries season 2 episode 21, Maomao continues developing age-reversing medicine under Lady Shenmei's order. Kyou-u’s escape attempt fails, leading to his capture and Maomao's punishment after insulting Lady Shenmei. Suirei is also beaten when she intervenes. Maomao is thrown into "the pit," where she survives by eating snakes.

She discovers a gunpowder facility and learns of Loulan’s betrayal, as workers are paid off before an explosion. Loulan reveals Suirei’s tragic royal lineage and her own rejection of nobility. The episode ends grimly with Loulan poisoning Kyou-u and 3 children, claiming mercy before the army arrives. Kyou-u dies in Maomao’s arms, aware of his fate.

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What to expect in The Apothecary Diaries season 2 episode 22? (speculative)

Jinshi (Image via OLM / TOHO Animation)

In The Apothecary Diaries season 2 episode 22, Loulan bringing Maomao to the dying children, which can possibly mean that she is hoping that Maomao can create the resurrection potion. This may suggest a hidden motive behind Loulan's actions, using Maomao’s pharmaceutical skills as a last resort.

As the imperial army approaches, Jinshi may finally reveal his true identity as the Moon Prince. He could then assume military command, shifting from political maneuvering to battlefield leadership.

Maomao will face a harrowing moral choice—whether she can save the children in time. The crumbling stronghold and Loulan’s desperate move set the stage for either a miraculous salvation or a deepening tragedy amid the chaos.

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