Diablo 4 Season 9: Best Horadric Spell combos to try

Diablo 4 Season 9’s Horadric Spell combos allow players to do some truly ridiculous damage, and we’ve filtered out some of the best ones to try. These can work in a wide assortment of builds, but they aren’t guaranteed for every single build. That’s part of the charm; there are so many fantastic ways to adjust these. One of the most important parts is the Infusion, though. You certainly want to use whichever one benefits your build the most.

For example, if you’re playing a Fire Hydra build, and all your damage is built around fire, it’s probably not advised to use Nebulous Extract, though it is entirely up to you. However, if you want to know what some of the best Horadric spell combos to try are in Diablo 4 Season 9, we’re here to help you out.

Note: The format for all of these Horadric Spells is [Catalyst] + [Infusion] + [Arcana].

What are some of the best Horadric Spell combos to try in Diablo 4 Season 9?

Cosmic Anomaly + Nebulous Extract + Bloody Charm + Tranquil Stone + Fractured Core
Celestial Surge + Smoldering Ember + Sapping Crux + Siphoning Gaze + Bloody Charm
Celestial Surge + Corrosive Vapor + Bottled Wind + Fractured Core + Reactive Ooze
Astral Pillar + Corrosive Vapor + Fractured Core + Potent Alloy + Bloody Charm

As a Necromancer player in Diablo 4 Season 9, Cosmic Anomaly + Nebulous Extract + Bloody Charm + Tranquil Stone + Fractured Core is going to be the Horadric Spell combo I likely use the most. In general, any build that wants to have lots of things being summoned will get plenty out of Cosmic Anomaly. In this case, I’ll pair it with Blight, though Blood Wave also works, if you’re running a Blood Wave build. It will still be a powerful combo.

Cosmic Anomaly is going to be a big hit this season (Image via Blizzard Entertainment)

It manifests Anomalies that deal damage over 4 seconds, and you can commend them to explode as well. The damage will also be Shadow and/or Corrupting damage, and thanks to Bloody Charm, it makes our Cosmic Anomaly explosions Execute non-bosses with 20% or less HP.

It also adds to Attack Speed, which my minions will no doubt take advantage of. I would also potentially swap Nebulous with Smoldering if I’m playing a Sorcerer/Fire Hydra build. I'm also a fan, as an idle thought, of Celestial Surge with this, to pull enemies together and spam Corpse Explosion on a Necromancer. You can add more Arcana, up to a total of three. We use Tranquil Stone to gain Unstoppable when our power activates, and Fractured Core to remove Damage Resistance Aura effects.

Another great pick for Diablo 4 Season 9 Horadric Spell combos is for players who want all their enemies to be in a nice clump: Celestial Surge + Smoldering Ember + Sapping Crux + Siphoning Gaze + Bloody Charm. I think Barbarians will love this combo, and I can see it being fun when paired with Flay in particular.

If enemies are all neatly packed, you can demolish them with ease. This also adds Fire damage, and gives enemies Vulnerable for 8s. If they somehow manage to survive the first bombardment, they won’t survive what comes after. You combine all of this with Lucky Hit to have your Catalyst consume DoT effects (Siphoning Gizmo) and the super fun Execute that comes with Bloody Charm. I could also see this being a lot of fun with Disintegrate as well for your primary power, just for the sheer damage that it could crank out.

If you want to run a Thorns build, you want to live long enough for that damage to start ticking. For this Diablo 4 Season 9 Horadric Spell combo, we’re going with Celestial Surge + Corrosive Vapor + Vapor + Bottled Wind + Fractured Core + Reactive Ooze. I think this will benefit Spiritborn in particular, as their Poison Thorns/Poison Volley is one of the strongest this season.

Let's just hope that the Horadric Jewels, which enhance these spells, won't be a pain to farm (Image via Blizzard Entertainment)

By pairing Celestial Surge with Quill Volley, you’ll drag enemies in, poison them swiftly, and then also gain a Barrier to keep yourself fit and healthy. The Quill Volley is already grossly powerful, but by using Corrosive Vapor, enemies hit by it will take a ton of Poison damage over 4s. We also remove Damage Resistance Aura powers from our enemies (Fractured Core) and greater resource generation (Reactive Ooze) per second, allowing you to pummel the field with even more abilities.

If you’ve noticed a Poisonous trend, that’s because I think it’s going to be very strong with certain builds. Astral Pillar + Corrosive Vapor + Fractured Core + Potent Alloy + Bloody Charm is one of those cases. Astral Pillar makes something that taunts enemies when activated, and Corrosive Vapor will make sure they’re poisoned.

As a Druid, pair this with Earthen Bulwark and the Fleshrender Unique to do huge fountains of poison damage, and even the extra damage you take due to Fractured Core will be dampened by Earthen Bulwark. Combining that with the barrier destruction/knock down (Potent Alloy) and the extra waves launched at executable enemies (Bloody Charm) makes it a fun experience.

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About the author

Jason is an Esports and Gaming journalist at Sportskeeda holding an amazing 11 years of experience under his belt. Having put out 4000-plus articles and amassing over 12 million reads for Sportskeeda, he is among the company’s most experienced writers. Jason holds a Bachelor's degree in English from UNC Pembroke and was inspired to become a gaming journalist very early on in life after reading Nintendo Power.

Jason is a jack of all trades when it comes to gaming journalism. He’s a key writer in Sportskeeda's MMO department, but he also likes to help out in other categories, like streamers, RPG, card games, and whatever else is needed. A solo gamer at heart, Jason's favorite titles include Earthbound and Dragon Warrior.

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Edited by Jason Parker