The full squads' list of all 8 teams playing in The Hundred Women's 2022 are as follows:
| Birmingham Phoenix | London Spirit | Manchester Originals | Northern Superchargers |
| Sophie Molineux | Beth Mooney | Deandra Dottin | Hollie Armitage |
| Sterre Kalis | Amelia Kerr | Amy Satterthwaite | Alice Davidson-Richards |
| Emily Arlott | Megan Schutt | Ami Campbell | Alyssa Healy |
| Gwen Davies | Sophie Luff | Phoebe Graham | Bess Heath |
| Sophie Devine | Amara Carr | Georgie Boyce | Beth Langston |
| Georgia Elwiss | Freya Davies | Kate Cross | Katie Levick |
| Ria Fackrell | Naomi Dattani | Sophie Ecclestone | Kalea Moore |
| Phoebe Franklin | Charlie Dean | Cordelia Griffith | Jemimah Rodrigues |
| Kirstie Gordon | Danielle Gibson | Laura Jackson | Liz Russell |
| Amy Jones | Heather Knight | Hannah Jones | Linsey Smith |
| Eve Jones | Alice Monaghan | Emma Lamb | Laura Wolvaardt |
| Ellyse Perry | Grace Scrivens | Lizelle Lee | Jenny Gunn |
| Abtaha Maqsood | Jess Kerr | Ellie Threlkeld | Lucy Higham |
| Issy Wong | Natasha Wraith | Grace Potts | Heather Graham |
| Deepti Sharma | Nancy Harman | Lea Tahuhu | Bethany Harmer |
| Davina Perrin | Grace Ballinger | Mahika Gaur | Rachel Slater |
| Oval Invincibles | Southern Brave | Trent Rockets | Welsh Fire |
| Lauren Winfield-Hill | Tahlia McGrath | Meg Lanning | Tammy Beaumont |
| Alice Capsey | Georgia Adams | Mignon du Preez | Rachael Haynes |
| Grace Gibbs | Lauren Bell | Bryony Smith | Annabel Sutherland |
| Danielle Gregory | Maia Bouchier | Alana King | Fran Wilson |
| Shabnim Ismail | Sophia Dunkley | Katherine Brunt | Alex Hartley |
| Sophia Smale (replaced Emma Jones) | Smriti Mandhana | Kathryn Bryce | Fi Morris |
| Marizanne Kapp | Tara Norris | Abbey Freeborn | Sarah Bryce |
| Dane van Niekerk | Carla Rudd | Sarah Glenn | Hannah Baker |
| Mady Villiers | Paige Scholfield | Nat Sciver | Lauren Filer |
| Aylish Cranstone | Anya Shrubsole | Marie Kelly | Katie George |
| Emily Windsor | Amanda-Jade Wellington | Sophie Munro | Alex Griffiths |
| Eva Gray | Danni Wyatt | Alexa Stonehouse | Nicole Harvey |
| Kira Chathli | Jo Gardner | Georgia Davis | Georgia Hennessy |
| Suzie Bates | Freya Kemp | Elyse Villani | Hayley Matthews |
| Ryana MacDonald-Gay | Ella McCaughan | Ella Claridge | Claire Nicholas |
| Kirstie White | Molly Strano | Emma Marlow | Nicola Carey |
