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| Sl No | Player | Mat | 4s | Country |
| 1 | Sachin Tendulkar | 463 | 2016 | India |
| 2 | Sanath Jayasuriya | 445 | 1500 | Sri Lanka |
| 3 | KC Sangakkara | 404 | 1385 | Sri Lanka |
| 4 | Ricky Ponting | 375 | 1231 | Australia |
| 5 | Adam Gilchrist | 287 | 1162 | Australia |
| 6 | Virat Kohli | 254 | 1140 | India |
| 7 | Virender Sehwag | 251 | 1132 | India |
| 8 | Chris Gayle | 301 | 1128 | West Indies |
| 9 | Sourav Ganguly | 311 | 1122 | India |
| 10 | Mahela Jayawardene | 448 | 1119 | Sri lanka |
Sachin Tendulkar leads the list of players to hit most ODI fours with 2016 fours in 463 matches. He is followed by Sri Lankan legend Sanath Jayasuriya with 1500 fours in 445 matches.
