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WWE Fastlane 2021 took place on Sunday, March 21, 2021 at The Tropicana Field, Florida.
WWE Fastlane the final pay-per-view before the show hits the road to WrestleMania. Scheduled in March, it is the WWE's third pay-per-view of the year (first WWE PPV of the year being Royal Rumble in January followed by Elimination Chamber in February).
| No. | Stipulations | Matches | Results |
| 1 | WWE Women's Tag Team Championship Match | Nia Jax and Shayna Baszler (c) vs. Sasha Banks and Bianca Belair | Shayna Baszler and Nia Jax def. Sasha Banks and Bianca Belair to retain the Women's Tag Team Championships |
| 2 | Intercontinental Championship Match | Big E vs. Apollo Crews | Big E def. Apollo Crews |
| 3 | Singles Match | Braun Strowman vs. Elias | Braun Strowman def. Elias |
| 4 | Singles Match | Seth Rollins vs Shinsuke Nakamura | Seth Rollins def. Shinsuke Nakamura |
| 5 | No Holds Barred Match | Drew McIntyre vs. Sheamus | Drew McIntyre def. Sheamus |
| 6 | Intergender Match | Randy Orton vs. Alexa Bliss | Alexa Bliss def. Randy Orton |
| 7 | Universal Championship Match | Roman Reigns vs. Daniel Bryan | Roman Reigns def. Daniel Bryan to retain the Universal Championship |
