West Indies' Chris Gayle has hit 63 sixes in all of the T20 World Cups which makes him the player leading the chart for the most sixes hit in T20 World Cups.
| Pos | Player | Team | Matches | Runs | 4s | 6s | Avg | SR |
| 1 | Chris Gayle | West Indies | 33 | 965 | 78 | 63 | 34.46 | 142.75 |
| 2 | Yuvraj Singh | India | 31 | 593 | 38 | 33 | 23.72 | 128.91 |
| 3 | Rohit Sharma | India | 33 | 847 | 80 | 31 | 38.5 | 131.52 |
| 4 | David Warner | Australia | 30 | 762 | 80 | 31 | 27.21 | 135.1 |
| 5 | Shane Watson | Australia | 24 | 537 | 41 | 31 | 28.26 | 140.94 |
| 6 | AB de Villiers | South Africa | 30 | 717 | 51 | 30 | 29.87 | 143.4 |
| 7 | Jos Buttler | England | 21 | 574 | 45 | 26 | 41 | 144.58 |
| 8 | DJ Bravo | West Indies | 34 | 530 | 35 | 25 | 21.2 | 126.79 |
| 9 | Mahela Jayawardene | Sri Lanka | 31 | 1016 | 111 | 25 | 39.07 | 134.74 |
| 10 | JP Duminy | South Africa | 25 | 568 | 37 | 23 | 40.57 | 129.68 |
