UFC 280: Oliveira vs. Makhachev is a mixed martial arts event produced by the Ultimate Fighting Championship that will take place on October 22, 2022 at the Etihad Arena in Abu Dhabi, United Arab Emirates.
UFC 280
UFC 280 Main Card
| Weight Class | Fight |
| Lightweight | Charles Oliveira vs. Islam Makhachev |
| Bantamweight | Aljamain Sterling (c) vs. T.J. Dillashaw |
| Bantamweight | Petr Yan vs. Sean O'Malley |
| Lightweight | Beneil Dariush vs. Mateusz Gamrot |
| Women's Flyweight | Katlyn Chookagian vs. Manon Fiorot |
UFC 280 Preliminary Card
| Weight Class | Fight |
| Welterweight | Belal Muhammad vs. Sean Brady |
| Middleweight | Makhmud Muradov vs. Caio Borralho |
| Light Heavyweight | Nikita Krylov vs. Volkan Oezdemir |
| Featherweight | Zubaira Tukhugov vs. Lucas Almeida |
| Welterweight | Abubakar Nurmagomedov vs. Gadzhi Omargadzhiev |
| Flyweight | Muhammad Mokaev vs. Malcolm Gordon |
