Sri Lanka' dynamic duo of Mahela Jayawardene and Kumar Sangakkara scored 166 runs for the opening partnership, which is the highest opening partnership in all T20 World Cups.
| Pos | Players | Team | Runs | Opposition | Ground | Match Date |
| 1 | Mahela Jayawardene & Kumar Sangakkara | Sri Lanka | 166 | v West Indies | Bridgetown | 7 May 2010 |
| 2 | Babar Azam & Mohammad Rizwan | Pakistan | 152* | v India | Dubai (DSC) | 24 Oct 2021 |
| 3 | Alex Hales & Eoin Morgan | England | 152 | v Sri Lanka | Chattogram | 27 Mar 2014 |
| 4 | Chris Gayle & Dwayne Smith | West Indies | 145 | v South Africa | Johannesburg | 11 Sep 2007 |
| 5 | T. Dilshan & Mahela Jayawardene | Sri Lanka | 145 | v England | Chattogram | 27 Mar 2014 |
| 6 | Kamran Akmal & Salman Butt | Pakistan | 142 | v Bangladesh | Gros Islet | 1 May 2010 |
| 7 | KL Rahul & Rohit Sharma | India | 140 | v Afghanistan | Abu Dhabi | 3 Nov 2021 |
| 8 | Gautum Gambhir & Virendra Sehwag | India | 136 | v England | Durban | 19 Sep 2007 |
| 9 | Chris Gayle & Andre Fletcher | West Indies | 133 | v Australia | The Oval | 6 Jun 2009 |
| 10 | Shane Watson & David Warner | Australia | 133 | v India | Colombo (RPS) | 28 Sep 2012 |
