The Borderlands 4 One Fell Swoop Main Mission is the fifth in line, assuming you decide to tackle Idolator Sol first. This Main Mission will pit you against one of The Timekeeper's Lieutenants, during which you will be tasked to stop his Locust Bio-Weapon.
That said, here's how to get started with the Borderlands 4 One Fell Swoop Main Mission, the challenges you will face, and what you can expect to see towards the end.
Borderlands 4 One Fell Swoop Step-By-Step Walkthrough
Talk to Zadra at The Stubs

To start the Borderlands 4 One Fell Swoop Main Mission, you will have to talk to Zadra. You will likely be in her lab upon completing A Lot To Procress Main Mission, and as such, she shouldn't be hard to find.
Reach, Enter, and Sabotage Sol's Production Facility at Synthetic Nave

After you speak with her, you will have to go to Sol's Production Facility. Follow the map-marker, and you will eventually reach Synthetic Nave. Once there, you will have to sabotage his operations, which means destroying everything you can.
Open and Damage Synth Processor

Once you've progressed deep enough into the facility, you will be tasked with damaging the Synth Processor. Look for an opening in the system, and shoot its core. That will do the job.
Meet Zadra

Once you damage the Synth Processor, you'll have to go meet Zadra in the Borderlands 4 One Fell Swoop Main Mission. She will give you a new set of objectives to execute.
Find the Main Network Terminal and kill the Guards

Once you've spoken to Zadra, she will task you with finding the Main Network Terminal and disposing of the Guards in the area. This should be a breeze as it's just some running and shooting about.
Bypass the Armored Door and reach Sealed Wing

Next, you will have to find a way past the Armored Door since there's no way to open it. You'll need to use your Grapple to get through a small passage and get to the other side. Once you're out of the narrow passage, you will reach a control room.
Dispense Locust Sample and return to Zadra

Once inside the room, you will have to dispense Locust Samples. This is again a very straightforward task and simple to execute. Once done, return to Zadra, and she'll tell you that the bio-weapon is being loaded onto the ship. You will now have to race to stop it from taking off.
Defeat Bio-Bulkhead

As you try to approach the Airship in the Borderlands 4 One Fell Swoop Main Mission, you will encounter a Boss called Bio-Bulkhead. You'll need to use Locust Canisters to shred its armour and remove its immunity to inflict damage. Once done, you can then proceed to the Airship.
Reach Airship and then go to the Fast-Travel Point

After the fight ends, you will have to fight your way to the Airship. However, given that nothing is fair on Kairos, or rather, works in your favor, you will miss the Airship. You will then have to follow the objective marker and make your way to a Fast-Travel Point instead to get to the Airship. You'll need to clear some debris to activate it.
Enter Airship, Eject Thermal Capacitors, and Stop Sol's Locust Attack

After you reach the Airship. you will need to get aboard and sabotage it from within. The Thermal Capacitors will have to be ejected, and you will then have to destory parts of the ship to bring it down. Once this is done, Sol's Locust Attack will be stopped.
Abandon Ship

With the Airship now going down, it's time to abandon ship. At this point, a counter will appear, and you will have to dive off the ship to safety before it explodes. With that, the Borderlands 4 One Fell Swoop Main Mission will be completed.
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