The eagerly awaited matchup between the New England Patriots and Tom Brady's Tampa Bay Buccaneers is here. The regular season's biggest game has sent ticket prices sky-high, and bettors will want a slice of the action. Tom Brady's Buccaneers roll into Foxborough hungry to correct the wrongs of last week's defeat in Los Angeles.The Patriots must win to get their season back on track. Belichick's team looked incredibly poor as the Saints easily dispatched the Patriots. Falling to 1-3 would be unthinkable, and it'd place the Pats in a problematic hole as they attempt to make the playoffs in 2021. As matches go, this could be the biggest Week 4 game in recent NFL history.NBC Sports@NBCSportsTom Brady is returning to the place where it all started.Watch the @Buccaneers take on the @Patriots in week 4 of Sunday Night Football on NBC and @peacockTV.4:58 AM · Sep 27, 20219628Tom Brady is returning to the place where it all started.Watch the @Buccaneers take on the @Patriots in week 4 of Sunday Night Football on NBC and @peacockTV. https://t.co/hvKvjBpwJwTampa Bay Buccaneers vs. New England Patriots Match DetailsFixture - Tampa Bay Buccaneers vs. New England Patriots | Sunday Night Football | Week 4 of the 202 NFL regular seasonDate & Time - Sunday, 3 October, 8:20 PM ESTVenue: Gillettte Stadium, Patriot Place, FoxboroughTampa Bay Buccaneers vs. New England Patriots Betting OddsSpread:Bucs: -7, -112Patriots: +7, -108Moneyline:Bucs: -311Patriots: +261Totals:Bucs: O 49 (-114)Patriots: U 49 (-106)Tampa Bay Buccaneers vs. New England Patriots PicksUnderstandably, the Buccaneers are the favored team. The Patriots' dismal loss last week has forced the odds to move towards Bruce Arians' team. The Pats will play hard. It is their first primetime game of the season, and Belichick will know every facet of Brady's game. The defenses might get on top early, and the Pats could keep it close.New England Patriots@Patriots"Our first prime time game of the year against the defending Super Bowl champs, it has all of the makings to be a highly competitive game." 1-on-1 with @McCourtyTwins4:01 AM · Oct 1, 202118619"Our first prime time game of the year against the defending Super Bowl champs, it has all of the makings to be a highly competitive game." 1-on-1 with @McCourtyTwins https://t.co/lsUS2RzsprTampa Bay Buccaneers vs. New England Patriots Key InjuriesThe headline news for the Patriots is that scat-back James White is out for the foreseeable future. Safety Kyle Dugger is a doubt since he's battled a hamstring injury all week and could be limited in the game.The Bucs are monitoring Rob Gronkowski's status. The former Patriot got rattled by a big hit against the Rams, and there is concern about his ribs. Running back Joe Mixon looks likely to miss out as he's not practiced at all. Likewise for Jason Pierre-Paul. This game comes too soon for new Buccaneers player Richard Sherman.Tampa Bay Buccaneers vs. New England Patriots PredictionDuring Matt Patricia's turgid time as Lions head coach, the Lions managed to defeat the Patriots. Patricia's inside knowledge of the Patriots offense and Brady allowed him to curate a winning game plan. Bill Belichick is the greatest defensive coach of all time. Plus, he knows everything about Tom Brady. The Patriots will have to play a perfect game, but Belichick will prepare them perfectly. The Pats could just spring a surprise and breathe new life into their 2021 NFL campaign.