Kansas City Chiefs superstar quarterback Patrick MahomesThe Cleveland Browns and Kansas City Chiefs will face off in a highly anticipated Week 1 matchup this weekend. As the two heavily loaded rosters go head-to-head, here's a look at which team could edge the contest. Both teams think they're powerhouses in the AFC. But on Sunday, one team will stand above the other.Match detailsFixture - Cleveland Browns vs Kansas City Chiefs | 2021 NFL Regular Season Week 1Date & Time - Sunday, September 12, 4:25 PM ETVenue - Arrowhead Stadium, Kansas City, MissouriCleveland Browns PreviewThe Browns will look to see how their revamped defense handles the Chiefs' passing onslaught. Jadeveon Clowney, John Johnson III and Troy Hill were brought in to assist in the pass rush and secondary. If the defense holds its own, the offense can run through Nick Chubb and Kareem Hunt. The Browns will look to keep things n check and avoid putting their defense on the field too much.Key player - Odell Beckham Jr.Odell Beckham Jr. is coming off a torn ACL and didn't play in the preseason. The offense has capable wide receivers Jarvis Landry and Donovan Peoples-Jones. But Beckham is the ceiling raiser the Browns need in potential shootout games like this. Beckham's athleticism could be a nightmare for the Chiefs' secondary. This will be his first game since Week 7 last season.Nick Chubb and Kareem Hunt both averaged 5.7 yards per carry against the Chiefs in the playoffs. KC couldn't stop the run even when they didn't respect a single Browns deep threat. Imagine what happens when Odell Beckham steps on the field. pic.twitter.com/5BjrlZlje8— Nick Karns (@karnsies817) September 10, 2021Cleveland Browns predicted lineupQuarterback - Baker Mayfield Case KeenumRunning Back - Nick Chubb, Kareem Hunt, D'Ernest Johnson, Demetric FeltonFullback - Andy JanovichWide Receiver - Odell Beckham Jr., Jarvis Landry, Donovan Peoples-Jones, Rashard Higgins, Anthony SchwartzTight End - Austin Hooper, David Njoku, Harrison BryantOffensive Linemen - Jedrick Willis Jr., Joel Bitonio, JC Tretter, Wyatt Teller, Jack Conklin, James Hudson III, Michael Dunn, Nick Harris, Blake Hence, Chris HubbardDefensive Linemen - Myles Garrett, Malik Jackson, Andrew Billings, Jadeveon Clowney, Takkarist McKinley, Jordan Elliot, Malik McDowell, Joe Jackson, Tommy TogaiLinebacker - Mack Wilson Sr., Anthony Walker Jr., Sione Takitaki, Jeremiah Owusu-Koramoah, Malcolm Smith, Tony Fields IICornerback - Denzel Ward, Greg Newsome II, Troy Hill, Greedy Williams, A.J. GreenSafety - John Johnson III, Ronnie Harrison Jr., Grant Delpit, Richard LeCounte III, M.J. Stewart Jr.Kicker - Chase McLaughlinPunter - Jamie GillanReturners - Demetric Felton, Donovan Peoples-JonesKansas City Chiefs previewThe Chiefs will use Week 1 to see how in-sync their offense is. Their biggest change from a year ago is the offensive line with five new starters on it. Protecting Patrick Mahomes is a high priority against the duo of Clowney and Myles Garrett. Another position to watch is at safety, where Tyrann Mathieu's status is up in the air. Mathieu is a Jenga piece for the secondary and his loss could be exploited.The #Chiefs say Tyrann Mathieu’s status remains up in the air for Sunday against the #Browns, and that’s not a shock. Even for vaccinated individuals, return to play is a little more complicated than two negative tests. Deadline to activate him is 4 p.m. Saturday. @nflnetwork pic.twitter.com/Ndx9SeZriH— Tom Pelissero (@TomPelissero) September 9, 2021Key player - Orlando Brown Jr.Kansas City Chiefs left tackle Orlando Brown Jr.Out of all the new offensive linemen, none might be more important than Orlando Brown Jr, who was brought in from the Baltimore Ravens and is looking to earn a contract extension after 2021. Brown only allowed three sacks on 1,027 snaps in 2020. Going against the Browns duo of Garrett and Clowney is a tough matchup in Week 1. Brown will be tasked with holding them off to allow Mahomes time for plays downfield to develop.Kansas City Chiefs predicted lineupQuarterback - Patrick Mahomes, Chad HenneRunning Back - Clyde Edwards-Helaire, Darrel Williams, Jerick McKinnonFullback - Michael BurtonWide Receiver - Tyreke Hill, Mecole Hardman, Demarcus Robinson, Byron Pringle, Marcus Kemp, Daurice FountainTight End - Travis Kelce, Blake Bell, Noah Gray, Jody FortsonOffensive Linemen - Orlando Brown Jr., Joe Thuney, Creed Humphrey, Trey Smith, Lucas Niang, Mike Remmers, Nick Allegretti, Austin Blythe, Laurent Duvernay-Tardif, Andrew WylieDefensive Linemen - Chris Jones, Jarran Reed, Derrick Nnadi, Frank Clark, Alex Okafor, Tershawn Wharton, Khalen Saunders, Mike Danna, Joshua KaindohLinebacker - Ben Niemann, Anthony Hitchens, Nick Bolton, Dorian O'Daniel, Darius HarrisCornerback - Charvarius Ward, L'Jarius Sneed, Mike Hughes, Rashad Fenton, Chris Lammons, DeAndre BakerSafety - Daniel Sorenson, Tyrann Mathieu, Juan Thronhill, Armani WattsKicker - Harrison ButkerPunter - Tommy TownsendReturners - Mecole Hardman, Byron Pringle, Mike HughesBrowns vs Chiefs matchup predictionExpect the Browns to control the pace of the game. The Chiefs have a lot of firepower and will be able to score in a hurry. But the Browns defense will get a couple of crucial takeaways that give them a slight edge.It'll be a one-to-two possession game where both teams show a lot of positives. The Browns, though, will come out on top.