Detroit Lions vs. Cleveland Browns predictions, odds, and picks for Week 4 showdown

The Detroit Lions (2-1) will host the Cleveland Browns (1-2) for their Week 4 clash at Ford Field on Sunday. Both teams are heading into the matchup on the back of wins.

As the two teams look to continue their winning momentum on the weekend, we examine the predictions, odds, and picks for the Week 4 showdown.

Detroit Lions vs. Cleveland Browns: Game Details

Date and Time: Sunday, September 28, 2025, at 1:00 pm ET

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Game: Detroit Lions vs. Cleveland Browns

Venue: Ford Field, Detroit, MI

Detroit Lions vs. Cleveland Browns: Betting Odds (DraftKings)

Moneyline: Detroit Lions (-520), Cleveland Browns (+390)

Spread: Detroit Lions -10.5 (+105), Cleveland Browns +10.5 (-125)

Total: 44.5 (Over/Under: -105/-115)

Detroit Lions vs. Cleveland Browns: Picks

The Lions have been one of the most disciplined teams this season, a contrast to their upcoming opponents. However, the Browns pulled off one of the upsets of last week after beating the Green Bay Packers.

Despite their surprising win against the Packers, expect Detroit to cover the spread (-10.5) for the Week 4 clash.

Detroit Lions vs. Cleveland Browns: NFL Injury Report

Detroit Lions injury report:

G Miles Frazier (undisclosed) - Out

RB Sione Vaki (groin) - Questionable

DE Marcus Davenport (chest) - Out

Cleveland Browns injury report:

RT Jack Conklin (undisclosed) - Questionable

DT Mike Hall Jr. (undisclosed) - Questionable

DT Shelby Harris (undisclosed) - Questionable

Detroit Lions vs. Cleveland Browns: Prediction for Week 4

The Browns broke their losing streak with a morale-boosting win against the Packers in Week 3. However, they are expected to be up against a team looking to continue their winning rhythm.

Detroit was involved in a heavyweight battle against the Baltimore Ravens on Monday and came away with a 38-30 win after a hard-fought contest. While the Browns have been resilient with their defense, their offensive struggles, with Joe Flacco leading the lines, have been evident this season.

On the contrary, the Lions have used their offensive versatility to great effect this season and the contest is going to boil down to Cleveland's offensive strength and the Lions' offensive prowess. Expect the Lions to win the game despite Cleveland's resilience.

Score prediction: Detroit Lions 28, Cleveland Browns 18

About the author

Chaitanya Prakash is an editor who covers US Sports at Sportskeeda. His first brush with sportswriting was in 2012 when the greatest football manager of all time, Sir Alex Ferguson, bid farewell to the beautiful game.

Although having started out professionally as a cricket writer in 2022, Chaitanya's curiosity and indiscriminate interest in all sports in general eventually introduced him to America's favorite pastime.

While Chaitanya's favorite player from the current crop is the dynamic Venezuelan Ronald Acuna Jr., his all-time favorite, however, is Pedro Martinez, for his self-belief and consistency. He also rates Jose Bautista's iconic bat flip in 2015 as his favorite moment in baseball history.

Chaitanya specializes in reporting on technical aspects of the game or analyzing patterns behind specific plays. He also likes pondering over players' self-assessments following the conclusion of a game as it helps him get an idea of how they think about the sport in general.

When not cheering for his favorites across sports, Chaitanya likes being transported to the past through a good war documentary or a historical documentary in general.

Know More

Cleveland Browns Nation! Check out the latest Cleveland Browns Schedule and dive into the Browns Depth Chart for NFL Season 2024-25.

Edited by Chaitanya Prakash