The Buffalo Bills and Houston Texans have identical 3-1 records going into their Week 5 matchup. Given that each of the two teams are hot favorites to win their division, the game should be exciting.The Texans will try to build on their recent spectacular rebound victory over the Jacksonville Jaguars when they take on the Bills at home on Sunday.Let's take a look at how the Texans are faring health-wise ahead of their Week 5 matchup.Houston Texans injury reportThe Houston Texans' lack of significant rushing threat was on show in their 24-20 win over the Jacksonville Jaguars in Week 4. The team might face the same fate in Week 5, as RB Joe Mixon has been ruled out for the game due to an ankle issue.Additionally, Dameon Pierce (hamstring) is ruled questionable for the game, meaning that Cam Akers, the backup running back for the Texans, may have to carry more of the load in the backfield against the Bills.Defensive lineman duo Jerry Hughes (hip) and Derek Barnett (shoulder) won't feature for the Texans, as they have both been declared out for the Week 5 showdown.Below are all the other Texans' players that are carrying injury designations into Sunday's game:LB Jake Hansen (back) - DNP on Friday - QUESTIONABLEDT Kurt Hinish (calf) - Full practice on Friday - QUESTIONABLEDE Dylan Horton (illness) - Full practice on Friday - QUESTIONABLEWR Robert Woods (foot) - Limited practice on Friday - QUESTIONABLET Tytus Howard (hamstring) - DNP on Friday - QUESTIONABLEJoe Mixon injury updateThe Houston Texans will be without running back Joe Mixon, one of their best offensive players, for the third week straight.Mixon missed every practice this week and is unavailable for the crucial Week 5 battle against the Buffalo Bills. He sustained an ankle injury in the Week 2 loss to the Chicago Bears.Cam Akers and Dare Ogunbowale may need to take the reins once again in the backfield for the Texans, as running back Dameon Pierce is also questionable to play. Akers gained 53 yards on 13 rushes in the game against the Jaguars, while Ogunbowale delivered the game-winning rushing touchdown.Running back Joe Mixon of the Houston Texans - Source: GettyTank Dell injury updateWideout Tank Dell is expected to play in the Houston Texans' Week 5 matchup against the Buffalo Bills on Sunday. He had a chest injury that kept him out of the team's victory over the Jacksonville Jaguars last week, but on Friday, he was able to resume full practice participation.Dell delivered five catches for 62 yards in the Texans' Week 3 defeat against the Minnesota Vikings before suffering an injury.The Texans won 24–20 against the Jaguars in Week 4 thanks to the offensive tandem of Stefon Diggs and Nico Collins, as Dell was unable to play.Tank Dell #3 of the Houston Texans - Source: GettyWhere to watch Houston Texans vs Buffalo Bills in Week 5?The Buffalo Bills and Houston Texans will face off in a much-awaited NFL game on Sunday at 1:00 pm ET. The game will kick off at Houston, Texas's NRG Stadium and air on CBS.Game detailsDate and Time: Sunday, Oct. 6 at 1:00 p.m. ETLocation: NRG Stadium in Houston, TexasTV: CBSAnnouncers: Ian Eagle (play-by-play), Charles Davis (analyst) and Evan Washburn (sideline reporter)Live streaming: FuboTV