Jaguars vs 49ers projected starting lineup and depth chart for Week 4 | 2025 NFL season

The Jacksonville Jaguars and San Francisco 49ers will square off in a Week 4 matchup on Sunday at Levi's Stadium in Santa Clara.

The Jags have recorded two wins this season against the Carolina Panthers in Week 1 and the Houston Texans in Week 3. However, the two wins came at home and they aim to secure their first road win under coach Liam Coen in Week 4.

The 49ers are unbeaten after three games and are playing like one of the best teams in the NFC.

Let's find out below what Jacksonville and San Francisco's projected starting lineups for Week 4 look like.

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Jacksonville Jaguars vs. San Francisco 49ers projected starting lineup for Week 4

Jacksonville Jaguars projected starting lineup

Jacksonville Jaguars quarterback Trevor Lawrence - Source: Imagn

Below is how the Jacksonville Jaguars are projected to line up on offense to start the game against the San Francisco 49ers:

Position	Starter
QB	Trevor Lawrence
RB	Travis Etienne Jr.
WR	Brian Thomas Jr.
WR	Travis Hunter
WR	Dyami Brown
TE	Brenton Strange
LT	Walker Little
LG	Ezra Cleveland
C	Robert Hainsey
RG	Patrick Mekari
RT	Anton Harrison

Below is how the Jags will likely line up in defense against the 49ers on Sunday:

Position	Starter
LDE	Josh Hines-Allen
LDT	DaVon Hamilton
RDT	Arik Armstead
RDE	Travon Walker
WLB	Foyesade Oluokun
MLB	Devin Lloyd
SLB	Dennis Gardeck
LCB	Jarrian Jones
SS	Eric Murray
FS	Andrew Wingard
RCB	Tyson Campbell
NB	Jourdan Lewis

Below is how the Jaguars' special teams are projected to line up to start the game against the 49ers:

Position	Starter
PK	Cam Little
P	Logan Cooke
H	Logan Cooke
PR	Parker Washington
KR	Bhayshul Tuten
LS	Ross Matiscik

San Francisco 49ers projected starting lineup

Running back Christian McCaffrey of the San Francisco 49ers - Source: Getty

Below is how the 49ers are projected to line up on offense to start the game against the Jaguars:

Position	Starter
QB	Brock Purdy
RB	Christian McCaffrey
WR	Jauan Jennings
WR	Ricky Pearsall
WR	Kendrick Bourne
TE	Jake Tonges
FB	Kyle Juszczyk
LT	Trent Williams
LG	Connor Colby
C	Jake Brendel
RG	Dominick Puni
RT	Colton McKivitz

Below is how the Niners are projected to line up in defense to start the game against the Jaguars:

Position	Starter
LDE	Mykel Williams
LDT	Kalia Davis
RDT	Jordan Elliott
RDE	Bryce Huff
WLB	Dee Winters
MLB	Fred Warner
SLB	Luke Gifford
LCB	Renardo Green
SS	Marques Sigle
FS	Jason Pinnock
RCB	Deommodore Lenoir
NB	Upton Stout

Below is how the 49ers' special teams are projected to line up to start the game against the Jaguars:

Position	Starter
PK	Eddy Pineiro
P	Thomas Morstead
H	Thomas Morstead
PR	Skyy Moore
KR	Isaac Guerendo
LS	Jon Weeks

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Jacksonville Jaguars vs. San Francisco 49ers depth chart

Jacksonville Jaguars depth chart

Here’s a look at the Jaguars’ offensive depth chart:

Position	Starter	2nd	3rd	4th
QB	Trevor Lawrence	Nick Mullens	-	-
RB	Travis Etienne Jr.	Bhayshul Tuten	LeQuint Allen Jr.	Cody Schrader
WR	Brian Thomas Jr.	Parker Washington	-	-
WR	Travis Hunter	Tim Patrick	-	-
WR	Dyami Brown	Joshua Cephus (IR)	-	-
TE	Brenton Strange	Johnny Mundt	Hunter Long	-
LT	Walker Little	-	-	-
LG	Ezra Cleveland	Wyatt Milum (out)	Cooper Hodges (out)	-
C	Robert Hainsey	Jonah Monheim	-	-
RG	Patrick Mekari	Chuma Edoga	-	-
RT	Anton Harrison	Cole Van Lanen	-	-

Here’s a look at the Jaguars’ defensive depth chart:

Position	Starter	2nd	3rd
LDE	Josh Hines-Allen	Dawuane Smoot	Danny Striggow
LDT	DaVon Hamilton	Austin Johnson	Khalen Saunders
RDT	Arik Armstead	Maason Smith	-
RDE	Travon Walker	Emmanuel Ogbah	BJ Green II
WLB	Foyesade Oluokun	Jack Kiser	-
MLB	Devin Lloyd	Ventrell Miller	-
SLB	Dennis Gardeck	Yasir Abdullah	Jalen McLeod (IR)
LCB	Jarrian Jones	Travis Hunter	-
SS	Eric Murray	Rayuan Lane III	Kahlef Hailassie
FS	Andrew Wingard	Antonio Johnson	Caleb Ransaw (IR)
RCB	Tyson Campbell	Montaric Brown	-
NB	Jourdan Lewis	Christian Braswell	-

Below is a look at the Jags’ special teams depth chart:

Position	Starter	2nd	3rd
PK	Cam Little	-	-
P	Logan Cooke	-	-
H	Logan Cooke	-	-
PR	Parker Washington	-	-
KR	Bhayshul Tuten	Parker Washington	LeQuint Allen Jr.
LS	Ross Matiscik	-	-

San Francisco 49ers depth chart

Below is a look at the 49ers’ offensive depth chart:

Position	Starter	2nd	3rd	4th
QB	Brock Purdy	Mac Jones	Kurtis Rourke (out)	-
RB	Christian McCaffrey	Brian Robinson Jr.	Isaac Guerendo	Jordan James
WR	Jauan Jennings	Demarcus Robinson	Jordan Watkins (out)	Trent Taylor
WR	Ricky Pearsall	Marquez Valdes-Scantling	Brandon Aiyuk (out)	-
WR	Kendrick Bourne	Skyy Moore	Jacob Cowing (IR)	-
TE	Jake Tonges	Luke Farrell	Brayden Willis	George Kittle (IR)
FB	Kyle Juszczyk	-	-	-
LT	Trent Williams	Spencer Burford (IR)	-	-
LG	Connor Colby	Ben Bartch (IR)	-	-
C	Jake Brendel	Matt Hennessy	-	-
RG	Dominick Puni	Drew Moss	-	-
RT	Colton McKivitz	Austen Pleasants	Isaac Alarcon (suspended)

Below is a look at the 49ers’ defensive depth chart:

Position	Starter	2nd	3rd	4th
LDE	Mykel Williams	Yetur Gross-Matos	Tarron Jackson (IR)	-
LDT	Kalia Davis	Alfred Collins	Kevin Givens (IR)	-
RDT	Jordan Elliott	CJ West (out)	Jordan Jefferson	-
RDE	Bryce Huff	Sam Okuayinonu	Robert Beal Jr.	Nick Bosa (IR)
WLB	Dee Winters	Nick Martin	-	-
MLB	Fred Warner	Tatum Bethune	-	-
SLB	Luke Gifford	Curtis Robinson	-	-
LCB	Renardo Green	Tre Tomlinson (IR)	-	-
SS	Marques Sigle	Ji'Ayir Brown	-	-
FS	Jason Pinnock	Siran Neal	Malik Mustapha	-
RCB	Deommodore Lenoir	Darrell Luter Jr.	Jakob Robinson (IR)	-
NB	Upton Stout	Chase Lucas	-	-

Below is a look at the Niners’ special teams depth chart:

Position	Starter	2nd	3rd
PK	Eddy Pineiro	-	-
P	Thomas Morstead	-	-
H	Thomas Morstead	-	-
PR	Skyy Moore	Jordan Watkins (out)	Jacob Cowing (IR)
KR	Isaac Guerendo	Skyy Moore	-
LS	Jon Weeks	-	-

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How to watch the Jaguars vs. 49ers Week 4 game? TV schedule and live stream details

The Jacksonville Jaguars will face off against the San Francisco 49ers on Sunday, September 28, at Levi’s Stadium for a Week 4 matchup.

The Jags have a 2-1 record going into their Week 4 game, which is their best start to a season since 2022. They also started 2-1 three years ago and won the AFC South that season.

With a perfect 3-0 record going into this game, the 49ers will try to win again in Week 4 at home before facing the Los Angeles Rams and Tampa Bay Buccaneers on the road.

All the information you need to watch the game, including TV and streaming details, is provided below:

Date and Time: Sunday, September 28th, 4:05 P.M. ET

Location: Levi's Stadium, Santa Clara, California

TV: FOX

Announcers: Adam Amin (play-by-play), Mark Sanchez (color analyst), Kristina Pink (sideline reporter)

Live Streaming: FuboTV