The Indianapolis Colts are looking to bounce back after a tough loss in Week 12.The Indianapolis Colts were embarrassed in Week 12 by their AFC South division rival Tennessee Titans. The Colts defense failed to stop running back Derrick Henry. This week the rush defense of the Colts can breathe a little bit, since they are facing the worst rushing team in the NFL in the Houston Texans.The Houston Texans are looking to push their winning streak to three games against the Colts. Texans quarterback Deshaun Watson is looking to keep his hot streak going on Sunday. The Texans are looking to end their season strong and carry momentum into next season.DW4 gets it done. @awscloud | #WeAreTexans pic.twitter.com/Kh6dnn5chQ— Houston Texans (@HoustonTexans) December 3, 2020The Week 13 meeting between the Colts and Texans is going to be a must-watch game.Indianapolis Colts at Houston Texans Betting OddsColts odds: -190Texans odds: +165Spread: The Indianapolis Colts are heading into their road game against the Houston Texans as -3.5 point favorites.Indianapolis Colts at Houston Texans Picks1. Deshaun Watson will not commit a turnover against the Colts2. Wide receiver Will Fuller V will be missed on the Texans offense3. Texans WR Brandin Cooks will step up and find the end zone4. Colts QB Philip Rivers will pass for two touchdowns against the Texans defense5. Colts RB Jonathan Taylor will rush for over 100 yards and a touchdownIndianapolis Colts at Houston Texans Key NotesDeshaun Watson has not thrown an interception since Week 7Will Fuller V has scored four receiving touchdowns in the last five gamesTexans offense will need to have success running the footballThe Houston Texans are looking to push their win streak to three gamesColts defense is looking to bounce back after a horrible performance in Week 12The Houston Texans defense is ranked 31st in the NFL in rushing defenseHouston has been one dimensional a lot this season and the Colts defense is full of talentThe Indianapolis Colts defense is ranked in the top five in the NFLThe Houston Texans will be without wide receiver Will Fuller V and cornerback Bradley Roby who are suspended for six gamesPhilip Rivers has turned the football over in back-to-back gamesLowest completion % allowed by CBs:1. Xavier Rhodes - 43.82. Casey Hayward Jr. - 45.63. Darious Williams - 48.14. Xavien Howard - 48.5 pic.twitter.com/s7PoIEghx3— PFF (@PFF) December 3, 2020Indianapolis Colts at Houston Texans Key InjuriesIndianapolis Colts:QB: Philip Rivers, Questionable (toe)OT: Anthony Castonzo, Questionable (knee)P: Rigoberto Sanchez, Out (tumor)S: Khari Willis, Questionable (back and quadriceps)Houston Texans:P: Bryan Anger: QuestionableRB: C.J. Prosise, Questionable (illness)DT: Ross Blacklock, QuestionableIndianapolis Colts at Houston Texans PredictionsPrediction: Colts 34, Texans 21Money Line: Colts -185, Texans +165Against the Spread: Colts 6-5, Texans 4-7