One undefeated team, Arizona Cardinals, is left standing in the NFL heading into Week 6, and they don't seem to be slowing down anytime soon. The Buffalo Bills seem to be the new team to beat in the AFC as well.Several great games came down to the wire in NFL Week 5, with Lamar Jackson having his best game through the air in his career on Monday night in an overtime win over the Indianapolis Colts. The LA Chargers keep control of the AFC West, and the Jacksonville Jaguars are the only winless team left. Jon Gruden's resignation from his post with the Las Vegas Raiders could either sink the team's season or make them better going forward.NFL Week 6 Prediction, Odds, Picks and SpreadsNFL Week 6 kicks off with the Tampa Bay Buccaneers traveling to the Philadelphia Eagles, while the Miami Dolphins and Jacksonville Jaguars play in London on Sunday. Here's a betting guide for those who want an edge this week.NFL Thursday Night Football - Philadelphia Eagles vs Tampa Bay BuccaneersMike Garafolo@MikeGarafolo#Eagles TE Dallas Goedert, who is vaccinated, will need two negative tests before Thursday night to play vs. the #Buccaneers. Would seem unlikely. We’ll see.12:06 PM · Oct 12, 202140868#Eagles TE Dallas Goedert, who is vaccinated, will need two negative tests before Thursday night to play vs. the #Buccaneers. Would seem unlikely. We’ll see.Spread - Tampa Bay Buccaneers -7 pointsMoney Line - Tampa Bay Buccaneers -300, Philadelphia Eagles +250Over/Under - 52.5 pointsAdditional Prop Bet Pick - Tom Brady over 295.5 passing yards (-114)Game Picks - Tampa Bay Buccaneers to win (-300) but not cover the spread (-114), over 52.5 points (-110)Game Prediction - Tampa Bay Buccaneers 29 - Philadelphia Eagles - 26Jacksonville Jaguars vs Miami Dolphins - LondonField Yates@FieldYatesThe Dolphins have designated QB Tua Tagovailoa for return from IR. He's eligible to play this Sunday against the Jaguars.4:44 AM · Oct 12, 20211521227The Dolphins have designated QB Tua Tagovailoa for return from IR. He's eligible to play this Sunday against the Jaguars.Spread - Miami Dolphins -3.5 pointsMoney Line - Miami Dolphins -186, Jacksonville Jaguars +156Over/Under - 47 pointsAdditional Pro Bet Pick - First Half Point Total over 24 points (+110)Game Picks - Jacksonville Jaguars to win (+156), over 47 points (-110)Game Prediction - Jacksonville Jaguars 27 - Miami Dolphins 21Indianapolis Colts vs Houston TexansBrad James@BradfatherSpeakThe Colts lead the Texans 29-9 all-time in an RS series dating back to 2002. The Colts lead the series 16-3 at home.5:35 AM · Oct 12, 2021The Colts lead the Texans 29-9 all-time in an RS series dating back to 2002. The Colts lead the series 16-3 at home.Spread - Indianapolis Colts -9.5 pointsMoney Line - Indianapolis Colts -420, Houston Texans +330Over/Under - 42.5 pointsAdditional Prop Bet Pick - Indianapolis Colts to score first and lose (+620)Game Picks - Houston Texans to win (+330), over 42.5 points (-110)Game Prediction - Houston Texans 26 - Indianapolis Colts 20Chicago Bears vs Green Bay PackersZach Kruse@zachkruse2Packers are 19-3 against the Bears since 2011.8:06 AM · Oct 12, 20212636221Packers are 19-3 against the Bears since 2011.Spread - Green Bay Packers -4.5 pointsMoney Line - Green Bay Packers -215, Chicago Bears +180Over/Under - 45 pointsAdditional Prop Bet Pick - Chicago Bears to have under 19.5 points (+100)Game Picks - Green Bay Packers to win (-215) and cover the spread (-115), over 45 points (-108)Game Prediction - Green Bay Packers 27 - Chicago Bears 19Washington Football Team vs Kansas City ChiefsCharles Goldman@goldmctNFLThe last time the #Chiefs lost to WFT, Joe Theismann was QB for Washington. twitter.com/aaronladd0/sta…Aaron Ladd@aaronladd0#Chiefs are 9-1 all-time vs. Washington, the team'shighest winning percentage versus any team in the NFL4:26 AM · Oct 12, 202121#Chiefs are 9-1 all-time vs. Washington, the team'shighest winning percentage versus any team in the NFLThe last time the #Chiefs lost to WFT, Joe Theismann was QB for Washington. twitter.com/aaronladd0/sta…Spread - Kansas City Chiefs -7 pointsMoney Line - Kansas City Chiefs -330, Washington +265Over/Under - 55.5 pointsAdditional Prop Bet Pick - Total touchdowns scored in game under 6.5 (-112)Game Picks - Kansas City Chiefs to win (-330) but not cover spread (-106), under 55.5 points (-110)Game Prediction - Kansas City Chiefs 23 - Washington 16Carolina Panthers vs Minnesota VikingsNFL Talk@NFL_Talk_SportsPanthers’ HC Matt Rhule says he is “hopeful” RB Christian McCaffery can play this week vs. the Vikings.12:47 PM · Oct 11, 2021396Panthers’ HC Matt Rhule says he is “hopeful” RB Christian McCaffery can play this week vs. the Vikings.Spread - Minnesota Vikings -1 pointMoney Line - Minnesota Vikings -116, Carolina Panthers -102Over/Under - 46.5 pointsAdditional Prop Bet Pick - Carolina Panthers to lead at halftime, Minnesota Vikings to lead end of game (+750)Game Picks - Minnesota Vikings to win (-116) and cover spread (-114), over 46.5 points (-105)Game Prediction - Minnesota Vikings 29 - Carolina Panthers 24Baltimore Ravens vs LA ChargersChris Hayre@chrishayre4-1 Chargers at 4-1 Ravens on Sunday: Justin Herbert and Lamar Jackson will meet in Baltimore, each coming off career-high passing performances — and thrilling victories.11:30 AM · Oct 11, 202115651404-1 Chargers at 4-1 Ravens on Sunday: Justin Herbert and Lamar Jackson will meet in Baltimore, each coming off career-high passing performances — and thrilling victories.Spread - Baltimore Ravens -3 pointsMoney Line - Baltimore Ravens -154, LA Chargers +130Over/Under - 51.5 pointsAdditional Prop Bet Pick - Both teams with 2+ touchdowns in each half (+1420)Game Picks - Baltimore Ravens win (-154) and cover spread (-104), under 51.5 points (-106)Game Prediction - Baltimore Ravens 24 - LA Chargers 20Detroit Lions vs Cincinnati BengalsJakob Sanderson (RTDB) ↗️@FF_RTDB4 of 5 teams who played the Bengals set or tied their season high in RB targets that week.In total they’ve allowed 46 RB targets.The only team in the NFL whose targeted their RBs more than 46 times?The Detroit Lions, their week 6 opponent.🔥🔥🔥1:25 AM · Oct 12, 20217264 of 5 teams who played the Bengals set or tied their season high in RB targets that week.In total they’ve allowed 46 RB targets.The only team in the NFL whose targeted their RBs more than 46 times?The Detroit Lions, their week 6 opponent.🔥🔥🔥 https://t.co/4JH6Vp2T8jSpread - Cincinnati Bengals -3.5 pointsMoney Line - Cincinnati Bengals -186, Detroit Lions +156Over/Under - 47.5 pointsAdditional Prop Bet Pick - Detriot Lions winning at halftime (+142)Game Picks - Detroit Lions win (+156), over 47.5 points (-110)Game Prediction - Detroit Lions 27 - Cincinnati Bengals 23New York Giants vs LA RamsNY Daily News Sports@NYDNSportsThe Giants are extremely banged up.-Daniel Jones iffy for Rams-Kenny Golladay out 1-2 weeks-Rodarius Williams tears ACLAnd more:trib.al/y2rrZZd9:39 AM · Oct 11, 20211The Giants are extremely banged up.-Daniel Jones iffy for Rams-Kenny Golladay out 1-2 weeks-Rodarius Williams tears ACLAnd more:trib.al/y2rrZZdSpread - LA Rams -10.5 pointsMoney Line - LA Rams -550, New York Giants +410Over/Under - 47.5 pointsAdditional Prop Bet Pick - New York Giants score most points in 4th quarter (+160)Game Picks - LA Rams win (-550) and cover spread (-110), over 47.5 points (-110)Game Prediction - LA Rams 30 - New York Giants 17Cleveland Browns vs Arizona CardinalsMike Winchell@mrmikewinchDear @Browns, Be angry and take it out on the Arizona Cardinals next week by getting a big dub and handing them their first loss. Signed,Rams Fans twitter.com/SportsCenter/s…SportsCenter@SportsCenterThe Browns made NFL history ... and still lost to the Chargers 🤯8:43 AM · Oct 10, 202131220The Browns made NFL history ... and still lost to the Chargers 🤯 https://t.co/GY5kIpsWhtDear @Browns, Be angry and take it out on the Arizona Cardinals next week by getting a big dub and handing them their first loss. Signed,Rams Fans twitter.com/SportsCenter/s…Spread - Cleveland Browns -3 pointsMoney Line - Cleveland Browns -154, Arizona Cardinals +130Over/Under - 49.5 pointsAdditional Prop Bet Pick - Total Field Goals in game over 3.5 (+100)Game Picks - Arizona Cardinals win (+130), under 49.5 points (-110)Game Prediction - Arizona Cardinals 23 - Cleveland Browns 16Denver Broncos vs Las Vegas RaidersField Yates@FieldYatesThe Broncos are working out former Bills WR John Brown. He was most recently with the Raiders.4:46 AM · Oct 12, 202152358The Broncos are working out former Bills WR John Brown. He was most recently with the Raiders.Spread - Denver Broncos -3.5 pointsMoney Line - Denver Broncos -180, Las Vegas Raiders +152Over/Under - 44.5 pointsAdditional Prop Bet Pick - First Drive Result FG attempt (+430)Game Picks - Denver Broncos win (-180) and cover spread (-106), over 44.5 points (-106)Game Prediction - Denver Broncos 26 - Las Vegas Raiders 20New England Patriots vs Dallas CowboysJon Machota@jonmachotaCowboys DC Dan Quinn said you never get over losing a Super Bowl, but this week’s Cowboys vs. Patriots game has no connection with Quinn’s Falcons team losing to the Patriots in the Super Bowl. “Different team. We’ll go up there and we will fight.”4:59 AM · Oct 11, 202149427Cowboys DC Dan Quinn said you never get over losing a Super Bowl, but this week’s Cowboys vs. Patriots game has no connection with Quinn’s Falcons team losing to the Patriots in the Super Bowl. “Different team. We’ll go up there and we will fight.”Spread - Dallas Cowboys -4 pointsMoney Line - Dallas Cowboys -200, New England Patriots +168Over/Under - 50.5 pointsAdditional Prop Bet Pick - Total Field Goals First Half under 1.5 (+140)Game Picks - Dallas Cowboys win (-200) and cover spread (-110), under 50.5 points (-106)Game Prediction - Dallas Cowboys 21 - New England Patriots 17Sunday Night Football - Pittsburgh Steelers vs Seattle SeahawksPittsburgh Steelers@steelers#LIVE: Coach Tomlin addresses the media prior to our game against the Seahawks. twitter.com/i/broadcasts/1…12:00 PM · Oct 12, 202116633#LIVE: Coach Tomlin addresses the media prior to our game against the Seahawks. twitter.com/i/broadcasts/1…Spread - Pittsburgh Steelers -4.5 pointsMoney Line - Pittsburgh Steelers -220, Seattle Seahawks +184Over/Under - 42.5 pointsAdditional Prop Bet Pick - Pittsburgh Steelers (-2.5 spread) to win and over 42.5 points scored (+195)Game Picks - Pittsburgh Steelers win (-220) and cover spread (-110), over 42.5 points (-106)Game Prediction - Pittsburgh Steelers 26 - Seattle Seahawks 19Monday Night Football - Tennessee Titans vs Buffalo BillsCory Curtis@CoryCurtis2So the Titans have the Bills on Monday Night Football. The Bills have the #1 scoring offense (34.4) and #1 scoring defense (12.8). So there's that.4:26 AM · Oct 11, 20211125So the Titans have the Bills on Monday Night Football. The Bills have the #1 scoring offense (34.4) and #1 scoring defense (12.8). So there's that.Spread - Buffalo Bills -5.5 pointsMoney Line - Buffalo Bills -250, Tennessee Titans +205Over/Under - 54 pointsAdditional Prop Bet Pick - Tennessee Titans to lead at half time, Buffalo Bills to lead at the end of game (+650)Game Picks - Buffalo Bills win (-250) and cover spread (-110), over 54 points (-110)Game Prediction - Buffalo Bills 31 - Tennessee Titans 26