Saints vs. 49ers projected starting lineup and depth chart for Week 2

The San Francisco 49ers are preparing for Sunday's Week 2 matchup with the New Orleans Saints in the Caesars Superdome in New Orleans. Following a 20–13 loss to the Arizona Cardinals in Week 1, the Saints will attempt to come out on top for the first time this season on Sunday against the Niners.

The 49ers enter Week 2 with a winning record following a narrow win against the Seattle Seahawks in the season opener. While that win was a perfect way to start the season, they are facing several injuries to important players, such as tight end George Kittle and quarterback Brock Purdy.

Here, we will take a look at the projected starting lineups of both sides ahead of the Week 2 clash.

New Orleans Saints vs. San Francisco 49ers projected starting lineup for Week 1

New Orleans Saints projected starting lineup

Tyler Shough of the New Orleans Saints - NFL Preseason 2025 - Source: Getty

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Below is how the Saints are projected to line up on offense to start the game against the 49ers:

Position	Starter
QB	Spencer Rattler
RB	Alvin Kamara
WR	Chris Olave
WR	Rashid Shaheed
WR	Brandin Cooks
TE	Juwan Johnson
LT	Kelvin Banks Jr.
LG	Dillon Radunz
C	Erik McCoy
RG	Cesar Ruiz
RT	Taliese Fuaga

Below is how the Saints could likely line up in defense against the 49ers on Sunday:

Position	Starter
LDE	Cameron Jordan
NT	Davon Godchaux
RDE	Bryan Bresee
WLB	Carl Granderson
LLB	Demario Davis
RLB	Pete Werner
SLB	Chris Rumph II
LCB	Kool-Aid McKinstry
SS	Justin Reid
FS	Jonas Sanker
RCB	Alontae Taylor
NB	Isaac Yiadom

Below is how the Saints' special teams are projected to line up to start the game against the 49ers:

Position	Starter
PK	Blake Grupe
P	Kai Kroeger
H	Kai Kroeger
PR	Rashid Shaheed
KR	Velus Jones Jr.
LS	Zach Wood

San Francisco 49ers projected starting lineup

San Francisco 49ers quarterback Brock Purdy - Source: Imagn

Below is how the 49ers are projected to line up on offense to start the game against the Saints:

Position	Starter
QB	Mac Jones
RB	Christian McCaffrey
WR	Jauan Jennings
WR	Ricky Pearsall
WR	Kendrick Bourne
TE	Luke Farrell
FB	Kyle Juszczyk
LT	Trent Williams
LG	Ben Bartch
C	Jake Brendel
RG	Dominick Puni
RT	Colton McKivitz

Below is how the Niners are projected to line up in defense to start the game against the Saints:

Position	Starter
LDE	Mykel Williams
LDT	Kalia Davis
RDT	Jordan Elliott
RDE	Nick Bosa
WLB	Dee Winters
MLB	Fred Warner
SLB	Luke Gifford
LCB	Renardo Green
SS	Ji'Ayir Brown
FS	Marques Sigle
RCB	Deommodore Lenoir
NB	Upton Stout

Below is how the 49ers' special teams are projected to line up to start the game against the Saints:

Position	Starter
PK	Eddy Pineiro
P	Thomas Morstead
H	Thomas Morstead
PR	Skyy Moore
KR	Isaac Guerendo
LS	Jon Weeks

New Orleans Saints vs. San Francisco 49ers depth chart

New Orleans Saints depth chart

Below is a look at the Saints’ offensive depth chart:

Position	Starter	2nd	3rd	4th
QB	Spencer Rattler	Tyler Shough	-	-
RB	Alvin Kamara	Kendre Miller	Devin Neal	Velus Jones Jr.
WR	Chris Olave	Devaughn Vele	Bub Means (IR)	-
WR	Rashid Shaheed	Mason Tipton	-	-
WR	Brandin Cooks	Trey Palmer	-	-
TE	Juwan Johnson	Jack Stoll	Moliki Matavao	Taysom Hill (out)
LT	Kelvin Banks Jr.	Asim Richards	Barry Wesley (IR)	Landon Young (IR)
LG	Trevor Penning (out)	Dillon Radunz	Torricelli Simpkins III	Nick Saldiveri (IR)
C	Eric McCoy	Luke Fortner	Will Clapp (IR)	-
RG	Cesar Ruiz	Xavier Truss	-	-
RT	Taliese Fuaga	-	-	-

Below is a look at the Saints’ defensive depth chart:

Position	Starter	2nd	3rd	4th
LDE	Cameron Jordan	Jonathan Bullard	Jonah Williams	-
NT	Davon Godchaux	Khristian Boyd	-	-
RDE	Bryan Bresee	Nathan Shepherd	Vernon Broughton	John Ridgeway III
WLB	Carl Granderson	-	-	-
LLB	Demario Davis	Danny Stutsman	Isaiah Stalbird	-
RLB	Pete Werner	Jaylan Ford	-	-
SLB	Chase Young	Chris Rumph II	-	-
LCB	Kool-Aid McKinstry	Quincy Riley	-	-
SS	Justin Reid	Jordan Howden	-	-
FS	Jonas Sanker	Julian Blackmon (out)	-	-
RCB	Alontae Taylor	Rejzohn Wright	-	-
NB	Isaac Yiadom	Ugo Amadi	-	-

Below is a look at the Saints’ special teams depth chart:

Position	Starter	2nd	3rd
PK	Blake Grupe	-	-
P	Kai Kroeger	-	-
H	Kai Kroeger	-	-
PR	Rashid Shaheed	Ugo Amadi	-
KR	Velus Jones Jr.	Kendre Miller	-
LS	Zach Wood	-	-

San Francisco 49ers depth chart

Below is a look at the 49ers’ offensive depth chart:

Position	Starter	2nd	3rd	4th
QB	Brock Purdy (out)	Mac Jones	Kurtis Rourke (out)	-
RB	Christian McCaffrey	Brian Robinson Jr.	Isaac Guerendo	Jordan James
WR	Ricky Pearsall	Jordan Watkins	Brandon Aiyuk (out)
WR	Jauan Jennings	Marquez Valdes-Scantling	Demarcus Robinson (suspended)	Trent Taylor
WR	Kendrick Bourne	Skyy Moore	Jacob Cowing (IR)	-
TE	George Kittle (IR)	Luke Farrell	Jake Tonges	-
FB	Kyle Juszczyk	-	-	-
LG	Ben Bartch	Connor Colby	-	-
LT	Trent Williams	Spencer Burford	-	-
C	Jake Brendel	Matt Hennessy	-	-
RT	Colton McKivitz	Austen Pleasants	Isaac Alarcon (suspended)	-
RG	Dominick Puni	Drew Moss	-	-

Below is a look at the 49ers’ defensive depth chart:

Position	Starter	2nd	3rd	4th
LDT	Kalia Davis	Alfred Collins	Kevin Givens (IR)	-
LDE	Mykel Williams	Yetur Gross-Matos	Bryce Huff	-
RDT	Jordan Elliott	CJ West	Jordan Jefferson	-
RDE	Nick Bosa	Sam Okuayinonu	Robert Beal Jr.	Tarron Jackson (IR)
WLB	Dee Winters	Nick Martin	-	-
MLB	Fred Warner	Tatum Bethune	-	-
SCB	Luke Gifford	-	-	-
LCB	Renardo Green	Tre Tomlinson (IR)	-	-
SS	Ji'Ayir Brown	Siran Neal	-	-
FS	Marques Sigle	Malik Mustapha (out)	-	-
RCB	Deommodore Lenoir	Darrell Luter Jr.	Jakob Robinson (IR)	-
NB	Upton Stout	Chase Lucas	-	-

Below is a look at the Niners’ special teams depth chart:

Position	Starter	2nd	3rd
PK	Eddy Pineiro	-	-
P	Thomas Morstead	-	-
H	Thomas Morstead	-	-
PR	Skyy Moore	Jordan Watkins	Jacob Cowing
KR	Isaac Guerendo	Skyy Moore	-
LS	Jon Weeks	-	-

How to watch the Saints vs. 49ers Week 2 game? TV schedule and live stream details

The 49ers will take on the Saints on Sunday at 1 p.m. ET. FOX will broadcast the game, with play-by-play announcer Kevin Kugler, color analyst Daryl Johnston, and sideline reporter Allison Williams providing commentary.

Fans can also stream the game via FuboTV and NFL+.

Game details:

Date and Time: Sunday, Sept. 14 at 1:00 p.m. ET

Location: Caesars Superdome in New Orleans, Louisiana

TV: FOX

Announcers: Kevin Kugler (play-by-play), Daryl Johnston (color analyst), Allison Williams (color analyst)

Live Streaming: FuboTV, NFL+

About the author

Habib Timileyin has been an NFL journalist at Sportskeeda for 2 years. He holds a Bachelor’s degree in English, and found himself drawn to the NFL about a decade ago.

Habib's favorite team is the Cincinnati Bengals and he particularly enjoyed their run to the Super Bowl in the 2021 season. The 2016 Super Bowl between the Atlanta Falcons and the New England Patriots is his most favorite of all time, and if given a chance to go back in time, he would love to witness the Patroits’ incredible comeback from being 28-3 down to winning 34-28.

Habib admires Tom Brady for his journey from being in a low draft position to achieving immense success in the game. His favorite coach of all time is Bill Belichick.

Habib likes to study intricate details of a story before reporting on it, and compares information among several reputable sources to ensure accuracy. When he's not writing about the NFL, Habib is likely watching Soccer, Basketball or enjoying a good movie on sports.

Know More

New Orleans Saints Nation! Check out the latest Saints Schedule and dive into the New Orleans Saints Depth Chart for NFL Season 2024-25.

Edited by Krutik Jain

Saints vs. 49ers projected starting lineup and depth chart for Week 2 | 2025 NFL season