On Sunday, the New Orleans Saints will be gunning for revenge when they host reigning Super Bowl champions and NFC South leaders, the Tampa Bay Buccaneers.The Saints beat the Buccaneers twice in the regular season in 2020 but lost against them in the playoffs. The defeat in January at the hands of Tom Brady and the Buccaneers was quarterback Drew Brees' last game in the NFL. The Saints are coming into this on the back of two gritty wins over Washington and the Seattle Seahawks.NFL UK@NFLUKAfter the Bucs beat the Saints in the Playoffs last season, @TomBrady spent time with Drew Brees and his family on the field. ❤️️(via @JamesPalmerTV)10:31 AM · Oct 30, 20211206After the Bucs beat the Saints in the Playoffs last season, @TomBrady spent time with Drew Brees and his family on the field. ❤️️(via @JamesPalmerTV) https://t.co/9O9woKcpf7Brady and the Buccaneers picked up where they left off last season and have eased their way to a 6-1 record. Tampa Bay has struggled with injuries in their secondary and on offense. But it hasn't seemed to bother them all that much so far.Saints vs. Buccaneers match detailsWhen: Sunday, October 31, 4:25 pmWhere: Caesars Superdome, New Orleans, LASaints vs. Buccaneers betting oddsSpreadsSaints: +4.5 (-105)Buccaneers: -4.5 (-115)MoneylineSaints: +185Buccaneers: -225TotalsSaints: U48.5 (-110)Buccaneers: O48.5 (-110)Saints vs. Buccaneers picksThe Buccaneers have the meanest run defense in the NFL but are 10th in passing yards allowed per game. Saints head coach Sean Payton will want to exploit Tampa Bay's weakness against the pass and let Jameis Winston throw the ball a lot more. Expect Winston to throw for 275 yards each.NFL Africa@NFLAfricaDominant!🦾 @Buccaneers and @TomBrady at their clinical best during the first quarter against @ChicagoBears! #NFLAfrica2:27 AM · Oct 25, 202131Dominant!🦾 @Buccaneers and @TomBrady at their clinical best during the first quarter against @ChicagoBears! #NFLAfrica https://t.co/fUM0qyMeRiBrady leads the NFL in passing yards and touchdowns through Week 7. With Rob Gronkowski back, the veteran quarterback will have a massive weapon to target in the end zone. Brady will have no issues going for 300 yards and throwing for at least two touchdowns against the Saints.Saints vs. Buccaneers key injuriesSaintsWR Deonte Harris (Hamstring): QuestionableDE Payton Turner (Calf): OutQB Taysom Hill (Concussion): OutCB Marshon Lattimore (hand): TBDBuccaneersILB Lavonte David (Ankle): QuestionableCB Dee Delaney (Ankle): QuestionableTE Rob Gronkowski (Ribs): QuestionableOLB Jason Pierre-Paul (Shoulder/Hand): QuestionableCB Richard Sherman (hamstring): QuestionableSaints vs. Buccaneers head-to-headThe Saints and Buccaneers have faced each other 59 in the NFL and New Orleans leads the head-to-head series 37-22.The Saints were on a five-game winning streak against the Buccaneers before Tampa Bay beat them in the playoffs last season.Saints vs. Buccaneers PredictionThe Saints are hot-and-cold but mostly cold as they continue to find their identity in the post-Drew Brees era. The Buccaneers, on the other hand, are relentless and have been steamrolling opponents week after week. They can go joint-top of the NFC standings with a win on Sunday.Prediction: The Buccaneers ease to a victory by two scores.