Week 6 Fantasy Football RB Rankings and Picks feat. James Cook, Kyren Williams, De'Von Achane, and Ashton Jeanty

James Cook, Kyren Williams, De'Von Achane and Ashton Jeanty have risen to become tremendous stars. Their teams, fans and fantasy owners love them beyond measure.

Week 6 of the 2025 season places each of them in unique matchup situations. Figuring out which running back to start in your fantasy lineup can have a big impact on your weekly success.

We're here to help you make all the tough decisions, and we've ranked the best backs in pro football for your information.

Let's dive into the best running backs for this week in fantasy football.

Week 6 Fantasy Football RB Rankings

Here is the ranking for Week 6:

1. Jonathan Taylor
2. Bijan Robinson
3. Jahmyr Gibbs
4. Christian McCaffrey
5. Josh Jacobs
6. Saquon Barkley
7. James Cook
8. Kyren Williams
9. De'Von Achane
10. Ashton Jeanty
11. Derrick Henry
12. Javonte Williams
13. Rico Dowdle
14. Breece Hall
15. Jacory Croskey-Merritt
16. Quinshon Judkins
17. Cam Skattebo
18. Travis Etienne Jr.
19. Rachaad White
20. J.K. Dobbins
21. D'Andre Swift
22. Alvin Kamara
23. David Montgomery
24. Michael Carter
25. Tony Pollard
26. Kenneth Walker III
27. Jaylen Warren
28. Chase Brown
29. Zach Charbonnet
30. Rhamondre Stevenson

Some of these stars could have unusually productive games this week.

Week 6 Fantasy Football RB Picks

NFL: Las Vegas Raiders at Indianapolis Colts - Source: Imagn

Jonathan Taylor vs. ARI

The Indianapolis Colts are one of the best teams in pro football, and Jonathan Taylor is riding the crest of that wave. As the heartbeat of Indy, the Colts often go as Taylor goes.

In a Week 6 matchup against the Arizona Cardinals, expect the running back to have another strong performance. Arizona ranks 22nd versus opposing running backs.

Josh Jacobs vs. CIN

Coming off a bye week, the Green Bay Packers are ready to hit the struggling Cincinnati Bengals hard. Cincinnati is playing without quarterback Joe Burrow, and the team is on the rocky road of a 3-game losing streak.

Ranking 32nd in stopping running backs, they have next to no chance at capping Packers rusher Josh Jacobs.

Kyren Williams @BAL

LA Rams running back Kyren Williams is also facing one of the league's worst rushing defenses this week. The Baltimore Ravens are by no means famed for their defense, and things are looking even worse this week, as they run the risk of still not having quarterback Lamar Jackson back.

Look for Williams to have a big day in Baltimore.