| Date | Match | Time (IST) | Venue |
| 19 November 2021 | ATK Mohun Bagan vs Kerala Blasters FC | 19:30 | Nehru Stadium, Fatorda |
| 25 November 2021 | NorthEast United FC vs Kerala Blasters FC | 19:30 | Nehru Stadium, Fatorda |
| 28 November 2021 | Bengaluru FC vs Kerala Blasters FC | 19:30 | Athletic Stadium, Bambolim |
| 5 December 2021 | Kerala Blasters FC vs Odisha FC | 19:30 | Tilak Maidan Stadium |
| 12 December 2021 | SC East Bengal vs Kerala Blasters FC | 19:30 | Tilak Maidan Stadium |
| 19 December 2021 | Mumbai City FC vs Kerala Blasters FC | 19:30 | Nehru Stadium, Fatorda |
| 22 December 2021 | Chennaiyin FC vs Kerala Blasters FC | 19:30 | Tilak Maidan Stadium |
| 26 December 2021 | Kerala Blasters FC vs Jameshedpur FC | 19:30 | Tilak Maidan Stadium |
| 2 January 2022 | Kerala Blasters FC vs FC Goa | 19:30 | Tilak Maidan Stadium |
| 9 January 2022 | Kerala Blasters Fc vs Hyderabad FC | 19:30 | Tilak Maidan Stadium |
