| Date | Match | Time (IST) | Venue |
| 21 November 2021 | SC East Bengal vs Jamshedpur FC | 19:30 | Tilak Maidan Stadium |
| 27 November 2021 | SC East Bengal vs ATK Mohun Bagan | 19:30 | Tilak Maidan Stadium |
| 30 November 2021 | Odisha FC vs SC East Bengal | 19:30 | Tilak Maidan Stadium |
| 3 December 2021 | Chennaiyin FC vs SC East Bengal | 19:30 | Tilak Maidan Stadium |
| 7 December 2021 | SC East Bengal vs FC Goa | 19:30 | Tilak Maidan Stadium |
| 12 December 2021 | SC East Bengal vs Kerala Blasters | 19:30 | Tilak Maidan Stadium |
| 17 December 2021 | NorthEast United FC vs SC East Bengal | 19:30 | Nehru Stadium, Fatorda |
| 23 December 2021 | Hyderabad FC vs SC East Bengal | 19:30 | Athletic Stadium, Bambolim |
| 4 January 2022 | Bengaluru FC vs SC East Bengal | 19:30 | Athletic Stadium, Bambolim |
| 7 January 2022 | SC East Bengal vs Mumbai City FC | 19:30 | Tilak Maidan Stadium |
