The Buffalo Bills vs. Kansas City Chiefs feels like a playoff game despite being in Week 6 of the season. Entering this AFC clash, both teams sit atop the conference with identical 4 - 1 records, coming off wins in Week 5. The Bills dominated the Pittsburgh Steelers with a 38 - 3 victory, and the Chiefs won on Monday night by a 30 - 29 score over the Las Vegas Raiders.These sides have faced off twice in the postseason in the last two seasons. The Bills and Chiefs first squared off in the AFC Championship Game of the 2020 campaign at Arrowhead Stadium. Kansas City defeated Buffalo 38 -24 as Patrick Mahomes went for 325 yards passing with three touchdowns. Josh Allen had 287 passing yards, two touchdowns, and an interception in the loss.Last season in the AFC Divisional Round, the game was one for the NFL history books. Both Allen and Mahomes threw for a combined 707 passing yards and seven passing touchdowns as the game went into overtime. In the end, Mahomes tossed an eight-yard pass to All-Pro tight Travis Kelce for a 42 -36 victory.Kansas City Chiefs@ChiefsTime to buckle up. 2104223Time to buckle up. ⏰ https://t.co/hUKfgX6Jq9Betting Odds SummarySpread: Bills -2.5 (-118), Chiefs +2.5 (-104)Moneyline: Bills -142, Chiefs +120Total: Under/Over: 53.5 (-115/-105)Buffalo Bills@BuffaloBillsAll set for our flight to Kansas City. Listen to our Week 6 Playlist: bufbills.co/3Thx5GA81863All set for our flight to Kansas City. 🎶Listen to our Week 6 Playlist: bufbills.co/3Thx5GA https://t.co/YrOcuitMyiWhat time is the Bills vs Chiefs game tonight in Week 6?The game will kick off at GEHA Field at Arrowhead Stadium, Kansas City, Missouri at 4:25 PM ET.Which channel will broadcast the Bills vs Chiefs game tonight in Week 6?The game will be broadcast live on CBS Sports.How to watch the Bills vs Chiefs game tonight in Week 6 on the live stream?Fans can stream the game online on the NFL Game Pass app.Bills vs Chiefs predictionIt's hard to pick because we're watching two of the best quarterbacks in the NFL go at it once again in Allen and Mahomes. While the focus is on the offense, this game could very much boil down to which defense can stop the other offense.The Bills statically have the best defense in the entire NFL, allowing just 12.2 points per game. The Chiefs are tied for 23rd in total defense, allowing 25 points per game.PredictionThe Bills will pull this out they exact a bit of revenge on the Chiefs in the regular season, winning by at least three points.