NFL: Buffalo Bills schedule 2025: Game-by-game win-loss record predictions for all 17 games

The Buffalo Bills, led by 2024 MVP Josh Allen, will be looking to finally achieve the top prize in the NFL next season after years of playoff failures.

The Bills had a strong 2024 regular season, finishing with a record of 13-4 and securing the No. 2 seed in the AFC. However, Buffalo fell short of a Super Bowl appearance once again, losing 32-29 to Patrick Mahomes' Kansas City Chiefs.

Using the Sportskeeda Playoff Predictor, let's take a look at the Bills' 2025 schedule and project their final record.

Looking to predict NFL playoff Scenarios? Try our NFL Playoff Predictor for real-time simulations and stay ahead of the game!

Buffalo Bills 2025 Schedule

Week 1 (September 7): vs. Baltimore Ravens at home, 8:20 PM ET

Week 2 (September 14): at New York Jets, 1 PM ET

Week 3 (September 18): vs. Miami Dolphins at home, 8:15 PM ET

Week 4 (September 28): vs. New Orleans Saints at home, 1:00 PM ET

Week 5 (October 5): vs. New England Patriots at home, 8:20 PM ET

Week 6 (October 13): at Atlanta Falcons, 7:15 PM ET

Week 7: BYE

Week 8 (October 26): at Carolina Panthers, 1:00 PM ET

Week 9 (November 2): vs. Kansas City Chiefs at home, 4:25 PM ET

Week 10 (November 9): at Miami Dolphins, 1:00 PM ET

Week 11 (November 16): vs. Tampa Bay Buccaneers at home, 1:00 PM ET

Week 12 (November 20): at Houston Texans, 8:15 PM ET

Week 13 (November 30): at Pittsburgh Steelers, 4:25 PM ET

Week 14 (December 7): vs. Cincinnati Bengals at home, 4:25 PM ET

Week 15 (December 14): at New England Patriots, 1:00 PM ET

Week 16 (December 21): at Cleveland Browns, 1:00 PM ET

Week 17 (December 28): vs. Philadelphia Eagles at home, 4:25 PM ET

Week 18 (TBD): vs. New York Jets at home, time TBD

Buffalo Bills 2025: Game-by-Game Prediction

Week 1: Bills vs. Ravens

Prediction: 15-13

Week 2: Bills at Jets

Prediction: 25-21

Week 3: Bills vs. Dolphins

Prediction: 18-15

Week 4: Bills vs. Saints

Prediction: 17-15

Week 5: Bills vs. Patriots

Prediction: 33-18

Week 6: Bills at Falcons

Prediction: 38-25

Week 7: BYE

Week 8: Bills at Panthers

Prediction: 16-15

Week 9: Bills vs. Chiefs

Prediction: 29-24

Week 10: Bills at Dolphins

Prediction: 24-22

Week 11: Bills vs. Buccaneers

Prediction: 14-15

Week 12: Bills at Texans

Prediction: 14-15

Week 13: Bills at Steelers

Prediction: 21-19

Week 14: Bills vs. Bengals

Prediction: 16-15

Week 15: Bills at Patriots

Prediction: 32-29

Week 16: Bills at Browns

Prediction: 24-27

Week 17: Bills vs. Eagles

Prediction: 24-19

Week 18: Bills vs. Jets

Prediction: 30-16

Buffalo Bills' predicted 2025 regular-season record

Sportskeeda's Playoff Predictor projected that the Bills would finish the regular season with a record of 14-3 and secure first place in the AFC East division.

According to this prediction, the Bills would also earn the No. 1 seed in the AFC and receive a bye in the first round of the playoffs.

About the author

Joshua Gillesby is a College Sports journalist at Sportskeeda who graduated from McMaster University with a Bachelor's in Arts & Science.

Josh is based in Ontario, Canada and his favorite college team is the Notre Dame Fighting Irish, due in large part to his former hockey team being invited for a tour of the facilities and watching a game while there.

His favorite past college football player is Joe Burrow, as his 2019 season was incredible and a major reason behind LSU's playoff success and National Championship.

Outside of work, Josh enjoys traveling, reading, writing, and science.

Know More

Buffalo Bills Nation! Check out the latest Buffalo Bills Schedule and dive into the latest Bills Depth Chart for NFL Season 2024-25.

Edited by Joshua Gillesby