Buffalo Bills vs. New England Patriots projected starting lineup and depth chart for Week 5 | 2025 NFL season

The Buffalo Bills (4-0) will square off against the New England Patriots (2-2) in Week 5 of the 2025 NFL season on Sunday night. The game will kick off at 8:20 p.m. ET from Highmark Stadium in Orchard Park, New York.

Ahead of the Bills vs. Patriots game, here's a look at the projected lineups for both teams.

Buffalo Bills vs. New England Patriots projected starting lineup for Week 5

Buffalo Bills projected starting lineup

Buffalo Bills QB Josh Allen - Source: Imagn

Here's a look at the Bills' projected starters on offense vs. the Patriots:

Position	Starter
QB	Josh Allen
RB	James Cook
WR	Keon Coleman
WR	Khalil Shakir
WR	Joshua Palmer
TE	Dalton Kincaid
FB	Reggie Gilliam
LT	Dion Dawkins
LG	David Edwards
C	Connor McGovern
RG	O'Cyrus Torrence
RT	Spencer Brown

Here's a look at the Bills' projected starters on defense vs. the Patriots:

Position	Starter
LDE	Greg Rousseau
LDT	Ed Oliver
RDT	DaQuan Jones
RDE	Joey Bosa
WLB	Matt Milano
MLB	Terrel Bernard
SLB	Jimmy Ciarlo
LCB	Tre'Davious White
SS	Taylor Rapp
FS	Cole Bishop
RCB	Christian Benford
NB	Taron Johnson

Here's a look at the Bills' projected starters on special teams vs. the Patriots:

Position	Starter
PK	Matt Prater
P	Mitch Wishnowsky
H	Mitch Wishnowsky
PR	Brandon Codrington
KR	Brandon Codrington
LS	Reid Ferguson

New England Patriots projected starting lineup

NFL: New England Patriots QB Drake Maye - Source: Imagn

Here's a look at the Patriots' projected starters on offense vs. the Bills:

Position	Starter
QB	Drake Maye
RB	Rhamondre Stevenson
WR	Stefon Diggs
WR	Kayshon Boutte
WR	Mack Hollins
TE	Hunter Henry
FB	Jack Westover
LT	Will Campbell
LG	Jared Wilson
C	Garrett Bradbury
RG	Mike Onwenu
RT	Morgan Moses

Here's a look at the Patriots' projected starters on defense vs. the Bills:

Position	Starter
LDE	Christian Barmore
NT	Khyiris Tonga
RDE	Milton Williams
WLB	Harold Landry III
LILB	Robert Spillane
RILB	Christian Elliss
SLB	Elijah Ponder
LCB	Carlton Davis III
SS	Jaylinn Hawkins
FS	Craig Woodson
RCB	Christian Gonzalez
NB	Marcus Jones

Here's a look at the Patriots' projected starters on special teams vs. the Bills:

Position	Starter
PK	Andy Borregales
P	Bryce Baringer
H	Bryce Baringer
PR	Marcus Jones
KR	Antonio Gibson
LS	Julian Ashby

Buffalo Bills vs. New England Patriots depth chart for Week 5

Buffalo Bills depth chart

Here's a look at the Bills' depth chart for their offense:

Position	Starter	2nd	3rd	4th
QB	Josh Allen	Mitchell Trubisky	-	-
RB	James Cook	Ray Davis	Ty Johnson	-
WR	Keon Coleman	Curtis Samuel	-	-
WR	Khalil Shakir	Elijah Moore	-	-
WR	Joshua Palmer	Tyrell Shavers	-	-
TE	Dalton Kincaid	Dawson Knox	Jackson Hawes	-
FB	Reggie Gilliam	-	-	-
LT	Dion Dawkins	Ryan Van Demark	-	-
LG	David Edwards	Alec Anderson	-	-
C	Connor McGovern	Sedrick Van Pran-Granger	-	-
RG	O'Cyrus Torrence	-	-	-
RT	Spencer Brown (Q)	Chase Lundt	Tylan Grable (IR)	-

Here's a look at the Bills' depth chart for their defense:

Position	Starter	2nd	3rd	4th
LDE	Greg Rousseau	AJ Epenesa	Michael Hoecht (SUSP)	-
LDT	Ed Oliver (Q)	Deone Walker	Zion Logue	Phidarian Mathis
RDT	DaQuan Jones	T.J. Sanders (Q)	DeWayne Carter (IR)	-
RDE	Joey Bosa	Javon Solomon	Landon Jackson	-
WLB	Matt Milano (Q)	Shaq Thompson	-	-
MLB	Terrel Bernard	Joe Andreessen	-	-
SLB	Dorian Williams (O)	Jimmy Ciarlo	-	-
LCB	Tre'Davious White	Ja'Marcus Ingram	Maxwell Hairston (IR)	-
SS	Taylor Rapp	Damar Hamlin	Wande Owens (IR)	-
FS	Cole Bishop	Sam Franklin Jr.	-	-
RCB	Christian Benford	Dorian Strong (IR)	-	-
NB	Taron Johnson	Cam Lewis	Brandon Codrington	Jordan Hancock

Here's a look at the Bills' depth chart for their special teams:

Position	Starter	2nd	3rd	4th
PK	Matt Prater	Tyler Bass (IR)	-	-
P	Mitch Wishnowsky	Cameron Johnston (IR)	-	-
H	Mitch Wishnowsky	Cameron Johnston (IR)	-	-
PR	Brandon Codrington	Khalil Shakir	Elijah Moore	Curtis Samuel
KR	Brandon Codrington	Ty Johnson	Curtis Samuel	-
LS	Reid Ferguson	-	-	-

New England Patriots depth chart

Here's a look at the Patriots' depth chart for their offense:

Position	Starter	2nd	3rd	4th
QB	Drake Maye	Joshua Dobbs	Tommy DeVito	-
RB	Rhamondre Stevenson	TreVeyon Henderson	Antonio Gibson	Lan Larison IR
WR	Stefon Diggs	DeMario Douglas	-	-
WR	Kayshon Boutte	Kyle Williams	-	-
WR	Mack Hollins	Efton Chism III	-	-
TE	Hunter Henry	Austin Hooper	-	-
FB	Jack Westover	Brock Lampe IR	-	-
LT	Will Campbell	Vederian Lowe	-	-
LG	Jared Wilson	Ben Brown	Caedan Wallace	Layden Robinson IR
C	Garrett Bradbury	Ben Brown	-	-
RG	Mike Onwenu	Yasir Durant IR	-	-
RT	Morgan Moses	Marcus Bryant	-	-

Here's a look at the Patriots' depth chart for their defense:

Position	Starter	2nd	3rd	4th
LDE	Christian Barmore	Joshua Farmer	-	-
NT	Khyiris Tonga	Eric Gregory	Jaquelin Roy IR	-
RDE	Milton Williams Q	Cory Durden	-	-
WLB	Harold Landry III	Keion White	Anfernee Jennings	-
LILB	Robert Spillane	Marte Mapu	-	-
RILB	Christian Elliss	Jahlani Tavai Q	Jack Gibbens	-
SLB	K'Lavon Chaisson O	Elijah Ponder	-	-
LCB	Carlton Davis III Q	Charles Woods	-	-
SS	Jaylinn Hawkins	Kyle Dugger	Brenden Schooler	-
FS	Craig Woodson	Dell Pettus	-	-
RCB	Christian Gonzalez	Alex Austin	Marcellas Dial Jr. IR	-
NB	Marcus Jones	-	-	-

Here's a look at the Patriots' depth chart for their special teams:

Position	Starter	Backup(s)
Kicker (PK)	Andy Borregales	Parker Romo
Punter (P)	Bryce Baringer	None listed
Holder (H)	Bryce Baringer	None listed
Punt Returner (PR)	Marcus Jones	DeMario Douglas
Kick Returner (KR)	Antonio Gibson	TreVeyon Henderson
Long Snapper (LS)	Julian Ashby	None listed

How to watch the Buffalo Bills vs. New England Patriots game? TV channel and live stream details for Week 5 SNF contest

NFL: New England Patriots WR Stefon Diggs - Source: Imagn

The Bills vs. Patriots game will be broadcast live on NBC. Fans can also live stream the contest on Fubo or Peacock.