Buffalo Bills vs. New Orleans Saints projected starting lineup and depth chart for Week 4| 2025 NFL season

The Buffalo Bills and New Orleans Saints will clash on Sunday at Highmark Stadium. The Bills are 3-0 and living up to their billing as strong Super Bowl contenders, while the Saints are searching for their first victory.

With both teams preparing for their fourth game, let's examine their projected starting lineups, depth charts and how to watch the matchup.

Buffalo Bills vs. New Orleans Saints projected starting lineup for Week 4

Buffalo Bills' projected starting lineup

Here are the Bills' projected starters on offense versus the Saints.

Position	Name
WR	Joshua Palmer
LT	Dion Dawkins
LG	David Edwards
C	Connor McGovern
RG	O'Cyrus Torrence
RT	Spencer Brown
TE	Dalton Kincaid
QB	Josh Allen
RB	James Cook III
FB	Reggie Gilliam
WR	Khalil Shakir
WR	Keon Coleman

Buffalo's projected starters on defense are listed below.

Position	Name
DE	Greg Rousseau
DT	Ed Oliver
DT	DaQuan Jones
DE	Joey Bosa
LB	Matt Milano
LB	Terrel Bernard
LB	Dorian Williams
NCB	Taron Johnson
CB	Tre'Davious White
CB	Christian Benford
S	Taylor Rapp
S	Cole Bishop

Here are the Bills' projected starters on special teams.

Position	Name
K	Matt Prater
P	Cameron Johnston
H	Cameron Johnston
PR	Brandon Codrington
KOR	Brandon Codrington
LS	Reid Ferguson

New Orleans Saints' projected starting lineup

Here are the Saints' projected starters on offense versus the Bills.

Position	Name
WR	Chris Olave
LT	Kelvin Banks Jr.
LG	Trevor Penning
C	Erik McCoy
RG	Cesar Ruiz
RT	Taliese Fuaga
TE	Juwan Johnson
WR	Brandin Cooks
WR	Rashid Shaheed
QB	Spencer Rattler
RB	Alvin Kamara

The Saints' projected starters on defense are listed below.

Position	Name
EDGE	Carl Granderson
DL	Davon Godchaux
DL	Bryan Bresee
EDGE	Cameron Jordan
LB	Pete Werner
LB	Demario Davis
CB	Isaac Yiadom
S	Jonas Sanker
S	Justin Reid
CB	Kool-Aid McKinstry
CB	Alontae Taylor

Here are the Saints' projected starters on special teams.

Position	Name
P	Kai Kroeger
K	Blake Grupe
KO	Blake Grupe
LS	Zach Wood
H	Kai Kroeger
PR	Rashid Shaheed
KR	Velus Jones Jr.

Buffalo Bills vs. New Orleans Saints depth chart

Buffalo Bills' depth chart

Let's look at the Bills' projected depth chart on offense versus the Saints.

Position	First	Second	Third	Fourth
WR	Joshua Palmer	Curtis Samuel
LT	Dion Dawkins	Ryan Van Demark
LG	David Edwards	Alec Anderson
C	Connor McGovern	Alec Anderson	Sedrick Van Pran-Granger
RG	O'Cyrus Torrence	Alec Anderson
RT	Spencer Brown	Chase Lundt
TE	Dalton Kincaid	Dawson Knox	Jackson Hawes
QB	Josh Allen	Mitchell Trubisky
RB	James Cook III	Ray Davis	Ty Johnson
FB	Reggie Gilliam
WR	Khalil Shakir
WR	Keon Coleman	Tyrell Shavers

Here's a look at Buffalo's projected depth chart on defense.

Position	First	Second	Third	Fourth
DE	Greg Rousseau	A.J. Epenesa	Javon Solomon
DT	Ed Oliver	T.J. Sanders
DT	DaQuan Jones	Deone Walker
DE	Joey Bosa	Landon Jackson
LB	Matt Milano	Shaq Thompson
LB	Terrel Bernard	Joe Andreessen
LB	Dorian Williams
NCB	Taron Johnson	Cam Lewis	Jordan Hancock
CB	Tre'Davious White	Ja'Marcus Ingram	Brandon Codrington
CB	Christian Benford	Dorian Strong
S	Taylor Rapp	Cam Lewis	Jordan Hancock
S	Cole Bishop	Damar Hamlin

Let's look at the Bills' projected depth chart for special teams.

Position	First	Second	Third	Fourth
K	Matt Prater	Ray Davis
P	Cameron Johnston
H	Cameron Johnston
PR	Brandon Codrington	Khalil Shakir
KOR	Brandon Codrington	Ty Johnson
LS	Reid Ferguson

New Orleans Saints' depth chart

Let's take a look at the Saints' projected depth chart on offense versus the Bills.

Position	First	Second	Third	Fourth
WR	Chris Olave	Trey Palmer
LT	Kelvin Banks Jr.	Asim Richards
LG	Trevor Penning	Dillon Radunz	Torricelli Simpkins III
C	Erik McCoy	Luke Fortner
RG	Cesar Ruiz	Xavier Truss
RT	Taliese Fuaga	Asim Richards
TE	Juwan Johnson	Jack Stoll	Moliki Matavao
WR	Brandin Cooks	Mason Tipton
WR	Rashid Shaheed	Devaughn Vele
QB	Spencer Rattler	Tyler Shough
RB	Alvin Kamara	Kendre Miller	Velus Jones Jr.	Devin Neal

Here is New Orleans' projected depth on defense.

Position	First	Second	Third	Fourth
EDGE	Carl Granderson	Chase Young
DL	Davon Godchaux	Khristian Boyd	Jonah Williams
DL	Bryan Bresee	Nathan Shepherd	Jonathan Bullard
EDGE	Cameron Jordan	Chris Rumph II
LB	Pete Werner	Isaiah Stalbird	Jaylan Ford
LB	Demario Davis	Danny Stutsman
CB	Isaac Yiadom	Quincy Riley
S	Jonas Sanker	Jordan Howden
S	Justin Reid	Terrell Burgess
CB	Kool-Aid McKinstry	Rejzohn Wright
CB	Alontae Taylor	Ugo Amadi

Here is the Saints' projected depth chart for special teams.

Position	First	Second	Third	Fourth
P	Kai Kroeger
K	Blake Grupe
KO	Blake Grupe
LS	Zach Wood
H	Kai Kroeger
PR	Rashid Shaheed	Ugo Amadi
KR	Velus Jones Jr.	Kendre Miller

How to watch Bills vs. Saints? TV channel and live stream details for the Week 4 game

The Buffalo Bills have been deep postseason contenders for the majority of the Josh Allen era. The Sean McDermott-coached team is undefeated this season, racking up wins over the Baltimore Ravens, New York Jets and the Miami Dolphins.

The Bills recorded a 31-21 victory over their AFC East rivals at Highmark Stadium last Sunday, and never looked like they'll lose the game. Bufalo is averaging 34 points per game, but will still look to improve it versus the Saints in Week 4.

Meanwhile, New Orleans is 0-3 and desperate for a win. Its 44-13 loss to the Seattle Seahawks last Sunday was its worst of the campaign.

The game was already a blowout at haltime, as the Saints trailed 38-6. The defeat further reduced their already slim postseason hopes.

Here are the details for Sunday's Bills-Saints showdown.

• Date: Sunday, Sept. 28, 2025
• Livestream: FuboTV and DAZN
• Time: 1 p.m. ET
• TV channel: CBS
• Venue: Highmark Stadium