Chargers vs. Chiefs projected starting lineup and depth chart for Week 1 | 2025 NFL season

The LA Chargers will square off against the Kansas City Chiefs in Week 1 of the 2025 NFL season on Friday. The game will kick off at 8 p.m. ET from Corinthians Arena in São Paulo, Brazil.

Ahead of the Chargers vs. Chiefs clash, here's a look at the projected starting lineups for both teams.

LA Chargers vs. Kansas City Chiefs projected starting lineup for Week 1

LA Chargers projected starting lineup

NFL: Los Angeles Chargers QB Justin Herbert - Source: Imagn

Here's a look at the Chargers' projected starters on offense vs. the Chiefs:

Position	Starter
QB	Justin Herbert
RB	Omarion Hampton
WR	Ladd McConkey
WR	Quentin Johnston
WR	Keenan Allen
TE	Will Dissly
FB	Scott Matlock
LT	Joe Alt
LG	Zion Johnson
C	Bradley Bozeman
RG	Mekhi Becton
RT	Trey Pipkins III

Here's a look at the Chargers' projected starters on defense vs. the Chiefs:

Position	Starter
LDE	Da'Shawn Hand
NT	Teair Tart
RDE	Otito Ogbonnia
WLB	Tuli Tuipulotu
LILB	Daiyan Henley
RILB	Denzel Perryman
SLB	Khalil Mack
LCB	Donte Jackson
SS	Derwin James Jr.
FS	Alohi Gilman
RCB	Cam Hart
NB	Tarheeb Still

Here's a look at the Chargers' projected starters on special teams vs. the Chiefs:

Position	Player
PK	Cameron Dicker
P	JK Scott
H	JK Scott
PR	Derius Davis
KR	Derius Davis
LS	Tucker Fisk

Kansas City Chiefs' projected starting lineup

NFL: Kansas City Chiefs QB Patrick Mahomes - Source: Imagn

Here's a look at the Chiefs' projected starters on offense vs. the Chargers:

Position	Starter
QB	Patrick Mahomes
RB	Isiah Pacheco
WR	Xavier Worthy
WR	Hollywood Brown
WR	JuJu Smith-Schuster
TE	Travis Kelce
LT	Josh Simmons
LG	Kingsley Suamataia
C	Creed Humphrey
RG	Trey Smith
RT	Jawaan Taylor

Here's a look at the Chiefs' projected starters on defense vs. the Chargers:

Position	Starter
LDE	George Karlaftis
LDT	Chris Jones
RDT	Omarr Norman-Lott
RDE	Mike Danna
WLB	Drue Tranquill
MLB	Nick Bolton
SLB	Leo Chenal
LCB	Trent McDuffie
SS	Chamarri Conner
FS	Bryan Cook
RCB	Kristian Fulton
NB	Jaylen Watson

Here's a look at the Chiefs' projected starters on special teams vs. the Chargers:

Position	Starter
PK	Harrison Butker
P	Matt Araiza
H	Matt Araiza
PR	Nikko Remigio
KR	Nikko Remigio
LS	James Winchester

LA Chargers vs. Kansas City Chiefs depth chart

LA Chargers depth chart

Here's a look at the LA Chargers' depth chart for their offense:

Position	Starter	2nd	3rd	4th
QB	Justin Herbert	Trey Lance	-	-
RB	Omarion Hampton	Najee Harris	Hassan Haskins	-
WR	Ladd McConkey	Tre' Harris	-	-
WR	Quentin Johnston	KeAndre Lambert-Smith	-	-
WR	Keenan Allen	Derius Davis	-	-
TE	Will Dissly	Tyler Conklin	Oronde Gadsden II	Tucker Fisk
FB	Scott Matlock	-	-	-
LT	Joe Alt	Austin Deculus	Rashawn Slater IR	-
LG	Zion Johnson	-	-	-
C	Bradley Bozeman	Andre James	-	-
RG	Mekhi Becton	Jamaree Salyer	-	-
RT	Trey Pipkins III	Savion Washington O	-	-

Here's a look at the LA Chargers' depth chart for their defense:

Position	Starter	2nd	3rd	4th
LDE	Da'Shawn Hand	Scott Matlock	Justin Eboigbe	-
NT	Teair Tart	Jamaree Caldwell	-	-
RDE	Otito Ogbonnia	Naquan Jones	Josh Fuga IR	-
WLB	Tuli Tuipulotu	Kyle Kennard	Caleb Murphy	-
LILB	Daiyan Henley	Troy Dye	Marlowe Wax	-
RILB	Denzel Perryman	Del'Shawn Phillips	Junior Colson IR	-
SLB	Khalil Mack	Bud Dupree	-	-
LCB	Donte Jackson	Nikko Reed	Deane Leonard IR	Jordan Oladokun IR
SS	Derwin James Jr.	RJ Mickens	-	-
FS	Alohi Gilman	Elijah Molden	Kendall Williamson	-
RCB	Cam Hart	Benjamin St-Juste	Eric Rogers IR	-
NB	Tarheeb Still	Ja'Sir Taylor	-	-

Here's a look at the LA Chargers' depth chart for their special teams:

Position	Starter	2nd	3rd	4th
PK	Cameron Dicker	-	-	-
P	JK Scott	-	-	-
H	JK Scott	-	-	-
PR	Derius Davis	Ladd McConkey	KeAndre Lambert-Smith	-
KR	Derius Davis	Hassan Haskins	KeAndre Lambert-Smith	-
LS	Josh Harris IR	-	-	-

Kansas City Chiefs depth chart

Here's a look at the Kansas City Chiefs' depth chart for their offense:

Position	Starter	2nd String	3rd String	4th String
QB	Patrick Mahomes	Gardner Minshew	-	-
RB	Isiah Pacheco	Kareem Hunt	Elijah Mitchell	Brashard Smith
WR	Xavier Worthy	Jalen Royals (O)	Nikko Remigio	-
WR	Hollywood Brown	Tyquan Thornton	Rashee Rice (SUSP)	-
WR	JuJu Smith-Schuster	Jason Brownlee	-	-
TE	Travis Kelce	Noah Gray	Robert Tonyan	Jared Wiley
LT	Josh Simmons	Wanya Morris	-	-
LG	Kingsley Suamataia	Mike Caliendo	-	-
C	Creed Humphrey	Hunter Nourzad	-	-
RG	Trey Smith	Ethan Driskell (O)	-	-
RT	Jawaan Taylor	Jaylon Moore	-	-

Here's a look at the Kansas City Chiefs' depth chart for their defense:

Position	Starter	2nd String	3rd String	4th String
LDE	George Karlaftis	Charles Omenihu	Malik Herring	BJ Thompson (O)
LDT	Chris Jones	Jerry Tillery	-	-
RDT	Omarr Norman-Lott (Q)	Derrick Nnadi	-	-
RDE	Mike Danna	Ashton Gillotte	Felix Anudike-Uzomah (IR)	-
WLB	Drue Tranquill	Jeffrey Bassa	-	-
MLB	Nick Bolton	Jack Cochrane	Brandon George (IR)	-
SLB	Leo Chenal	Cooper McDonald	-	-
LCB	Trent McDuffie	Nazeeh Johnson (IR)	Eric Scott Jr. (IR)	-
SS	Chamarri Conner	Deon Bush (IR)	-	-
FS	Bryan Cook	Jaden Hicks	-	-
RCB	Kristian Fulton	Nohl Williams	Joshua Williams	-
NB	Jaylen Watson	-	-	-

Here's a look at the Kansas City Chiefs' depth chart for their special teams:

Position	Starter	2nd String	3rd String	4th String
PK	Harrison Butker	-	-	-
P	Matt Araiza	-	-	-
H	Matt Araiza	-	-	-
PR	Nikko Remigio	Brashard Smith	-	-
KR	Nikko Remigio	Brashard Smith	-	-
LS	James Winchester	-	-	-

How to watch Chargers vs. Chiefs Week 1 game? TV schedule and live stream details

The Chargers vs. Chiefs clash will not be broadcast on national TV. However, fans can live stream the game on YouTube, where Rich Eisen (play-by-play) and Kurt Warner (analyst) will be on the call. Donald De La Hayea and Stacey Dales will report from the sidelines.

Locals in Kansas City can watch the game on KSHB 41.

Here are some key details for the Chargers vs. Chiefs Week 1 game:

• Date: Friday, Sept. 5, 2025
• Time: 8 p.m. ET
• TV channel: NA, KSHB 41 for locals in Kansas City
• Live stream: YouTube or Fubo
• Venue: Corinthians Arena in São Paulo, Brazil