Running backs have always been some of the most important Fantasy Football players during each NFL season. They have the potential to put up huge scores in a given week, but can also bust when they face a difficult matchup.The truly elite running backs need to start every week in Fantasy Football. However, the rest of them should either be targeted or avoided depending on their specific match-ups each week. Here are some suggested starts and sits for Week 1 of the season.Week 1 Fantasy Football Running Backs: Start 'EmRunning backs to target in Week 1 Fantasy Football.James Conner - Arizona Cardinals vs. Kansas City ChiefsArizona Cardinals RB James ConnerJames Conner had a breakout year with the Arizona Cardinals last season. He could potentially take another step forward during this campaign. He's expected to receive an even larger workload following the departure of Chase Edmonds to the Miami Dolphins.Conner will find an excellent opportunity to get off to a fast start this Fantasy Football season. He plays against the Kansas City Chiefs defense in Week 1 and the game is projected to be a shootout between two high-powered offenses. The Chiefs also ranked in the bottom 12 in rushing yards allowed per game last season.Josh Jacobs - Las Vegas Raiders vs. Los Angeles ChargersLas Vegas Raiders RB Josh JacobsJosh Jacobs finds himself in an ideal Fantasy Football situation entering Week 1 of the season. He faces a familiar opponent this week in the Los Angeles Chargers, their division rival. The Las Vegas Raiders also faced off against them in the final game of the regular season last year.Raider Nation Boston@RaiderNationBOSJosh Jacobs is the only player in the NFL with multiple TDs on opening day each of the past three seasons.2145219Josh Jacobs is the only player in the NFL with multiple TDs on opening day each of the past three seasons.https://t.co/Ys04HDrG6lJacobs will be looking for a similar result in this game. He set a season-high of 132 rushing yards in the matchup against the third-worst rushing defense in the NFL last season. This game also has shootout potential, as their previous game totaled 67 points.Elijah Mitchell - San Francisco 49ers vs. Chicago BearsSan Francisco 49ers RB Elijah MitchellWhile Elijah Mitchell battled some injuries during the 2021 NFL season, he was one of the most efficient rushers in the games that he did play. He received at least ten carries in nine games last season and eclipsed 85 rushing yards in seven of them. Mitchell exceeded 115 yards three times in the campaign.Mitchell has an intriguing Fantasy Football matchup in Week 1 against the Chicago Bears, who ranked in the bottom ten in rushing yards allowed per game. He should be called on often, as the San Francisco 49ers prefer a run-heavy offense.