Running backs have always been some of the most important players in Fantasy Football. They have the ability to put up massive numbers in the right match-up, while also having bust potential when facing a difficult situation.These swings can be the difference between winning and losing in a weekly Fantasy Football match-up.While most fantasy teams should start their superstar running backs just about every week, the next tier of players is crucial to analyze and adjust fantasy lineups accordingly. Here are three running backs to target and three others to avoid in Fantasy Football for Week 2 of the 2022 NFL season.Week 2 Fantasy Football Running Backs: Start 'EmDevin Singletary - Buffalo Bills vs. Tennessee TitansBuffalo Bills RB Devin SingletaryFor the second consecutive year, Devin Singletary entered the 2022 NFL season in what appeared to a be a committee of running backs that would compete for carries each week. He emerged as the clear-cut top choice during the 2021 season, and so far in 2022, he has once again proven to be the most productive running back for the Buffalo Bills.Playing in the Bills' high-powered offense will present plenty of opportunities for their players to produce solid Fantasy Football production. Singletary averaged six yards per carry in Week 1, and now faces off against a Tennessee Titans defense that was just torched by Saquon Barkley last week for 194 total yards.Jeff Wilson - San Francisco 49ers vs. Seattle SeahawksSan Francisco 49ers RB Jeff WilsonJeff Wilson opened the 2022 NFL season as the back-up running back for the San Francisco 49ers. He will now likely get the opportunity to start in Week 2 against the Seattle Seahawks after starter Elijah Mitchell was knocked out of the 49ers Week 1 game with a knee injury.Field Yates@FieldYatesJeff Wilson, Jr. has delivered for the 49ers in the past and they’ll need him to again now.21617Jeff Wilson, Jr. has delivered for the 49ers in the past and they’ll need him to again now. https://t.co/iRsDS6lsb6The 49ers offense often uses a run-heavy scheme. So Wilson should see plenty of opportunities for touches against a relatively weak Seattle Seahawks defense that will be without Jamal Adams, their best defensive player. Wilson is a top waiver wire pick this week, as well as a solid starting option in Fantasy Football.Michael Carter - New York Jets vs. Ceveland BrownsNew York Jets RB Michael CarterBreece Hall was one of the most hyped rookie running backs for Fantasy Football entering the 2022 NFL season. His dynamic dual-threat skillset in college football appears to have translated well into the NFL as he was projected to be the starter for the New York Jets. He also received a massive workload, similar to Najee Harris last season.In a bit of a surprising twist, it was Michael Carter who featured more at running back for the Jets in Week 1. Carter received 17 touches for 100 yards, while Hall chipped in with 12 touches for 61 yards.Carter appears to be the lead back for the Jets, at least for now, and looks like a solid flex play in Week 3 against the Cleveland Browns.