Kyler Murray and the Arizona Cardinals suffered a close 25-24 loss against the Los Angeles Chargers at home on Sunday. Arizona led by seven points with only 18 seconds left in the game, but an Austin Ekeler touchdown gave the Chargers the opportunity to tie the game.Instead of attempting an extra point kick to force overtime, the Chargers went for two and converted to take the lead with only 15 seconds left in the game. Here's the touchdown:Los Angeles Chargers@chargersFOR THE DUB.2319333FOR THE DUB. https://t.co/gjLoqCTkMCAnd here is the two-point conversion:NFL@NFLTwo points and the lead for the @Chargers!: #LACvsAZ on CBS: Stream on NFL+ bit.ly/3F4mmel1495282Two points and the lead for the @Chargers!📺: #LACvsAZ on CBS📱: Stream on NFL+ bit.ly/3F4mmel https://t.co/6wCBSXmtq3With so little time to respond, Arizona ended up losing the game by a point. This was made worse by the fact that they were in the driver's seat for most of the first and second quarters. However, midway through the second period, a massive error from the Cardinals' offense turned the tide of the contest. Facing a fourth-and-one from their own 35-yard line, the Cardinals decided to go for it.Instead of keeping it on the ground with running back James Conner, Kyler Murray aired the ball out to DeAndre Hopkins. Chargers safety Derwin James Jr. read the play and intercepted the pass.Los Angeles Chargers@chargersDERWIN IS THAT GUY.@DerwinJames | @NFLonCBS1264238DERWIN IS THAT GUY.@DerwinJames | @NFLonCBS https://t.co/jzpBDFaYngThe Chargers took full advantage of the break and scored the go-ahead touchdown. In hindsight, running the ball with Conner or Murray or simply punting it away would have been the wiser option. Hindsight is always 20-20, but this one really hurt Arizona's chances this season.In the post-game press conference, Murray was asked about the play. He responded:"That wasn't even supposed [to go to] Hop. Schematically we were kinda f***ed."Bo Brack@BoBrack“Schematically, we were kinda fucked.”Arizona Cardinals QB Kyler Murray on 4th & 1 interception1534233“Schematically, we were kinda fucked.”Arizona Cardinals QB Kyler Murray on 4th & 1 interception https://t.co/tcejKA1qTpKyler Murray's response was interpreted as a jibe at head coach Kliff Kingsbury, who is likely walking on thin ice.The Arizona Cardinals' playoff hopes may have been extinguishedWith this loss, the Arizona Cardinals dropped to 4-8 for the season. The San Francisco 49ers hold a 4.5-game lead over Arizona in the race for the NFC West division title. The Seattle Seahawks are in second place with a 6-5 record. Barring a complete meltdown by both teams and a dramatic change of fortune, Arizona won't win the NFC West.The Cardinals will have to run the table and hope teams currently occupying the wildcard positions have a disastrous end to their campaigns. In summary, their playoff hopes were all but dashed after this loss. Coach Kliff Kingsbury will have to finish the season strong to retain his place as head coach next season or he could be on his way out of Arizona at the end of the 2022 campaign.