LA Rams vs San Francisco 49ers projected starting lineup and depth chart for Week 5 TNF | 2025 NFL season

The LA Rams will host the San Francisco 49ers in a Week 5 Thursday Night Football game. The matchup will occur at SoFi Stadium.

With that being said, let's examine the starting lineups, depth charts and how to watch the game.

LA Rams vs San Francisco 49ers projected starting lineup for Week 5

LA Rams' projected starting lineup

These are the Rams' projected starters on offense vs the 49ers:

Position	Name
WR	Davante Adams
TE	Tyler Higbee
LT	Alaric Jackson
LG	Steve Avila
C	Coleman Shelton
RG	Kevin Dotson
RT	Rob Havenstein
WR	Tutu Atwell
WR	Puka Nacua
QB	Matthew Stafford
RB	Kyren Williams
WR	Davante Adams

These are the Rams' projected starters on defense vs the 49ers:

Position	Name
OLB	Byron Young
DE	Braden Fiske
NT	Poona Ford
DE	Kobie Turner
OLB	Jared Verse
ILB	Omar Speights
ILB	Nate Landman
CB	Emmanuel Forbes Jr.
S	Quentin Lake
S	Kam Curl
CB	Cobie Durant

These are the Rams' projected starters on special teams vs the 49ers:

Position	Name
P	Ethan Evans
K	Joshua Karty
H	Ethan Evans
LS	Alex Ward
PR	Xavier Smith
KR	Jordan Whittington

San Francisco 49ers' projected starting lineup

These are the 49ers' projected starters on offense vs the Rams:

Position	Name
WR	Jauan Jennings
LT	Trent Williams
LG	Connor Colby
C	Jake Brendel
RG	Dominick Puni
RT	Colton McKivitz
TE	Luke Farrell
WR	Ricky Pearsall
RB	Christian McCaffrey
FB	Kyle Juszczyk
QB	Brock Purdy

These are the 49ers' projected starters on defense vs the Rams:

Position	Name
LDE	Mykel Williams
LDT	Kalia Davis
RDT	Jordan Elliott
RDE	Nick Bosa
SAM	Luke Gifford
MIKE	Fred Warner
WILL	Dee Winters
LCB	Renardo Green
RCB	Deommodore Lenoir
NB	Upton Stout
FS	Jason Pinnock
SS	Marques Sigle

These are the 49ers' projected starters on special teams vs the Rams:

Position	Name
P	Thomas Morstead
K	Eddy Piñeiro
H	Thomas Morstead
PR	Skyy Moore
KOR	Isaac Guerendo
LS	Jon Weeks

LA Rams vs San Francisco 49ers depth chart

LA Rams' depth chart

This is the Rams' projected depth chart on offense vs the 49ers:

Position	First	Second	Third	Fourth
WR	Davante Adams	Jordan Whittington
TE	Tyler Higbee	Colby Parkinson	Davis Allen	Terrance Ferguson
LT	Alaric Jackson	D.J. Humphries	David Quessenberry
LG	Steve Avila	Justin Dedich
C	Coleman Shelton	Beaux Limmer
RG	Kevin Dotson
RT	Rob Havenstein	Warren McClendon Jr.
WR	Tutu Atwell	Xavier Smith
WR	Puka Nacua	Konata Mumpfield
QB	Matthew Stafford	Jimmy Garoppolo	Stetson Bennett IV
RB	Kyren Williams	Blake Corum	Jarquez Hunter
WR	Davante Adams	Jordan Whittington

This is the Rams' projected depth chart on defense vs the 49ers:

Position	First	Second	Third	Fourth
OLB	Byron Young	Josaiah Stewart
DE	Braden Fiske	Larrell Murchison	Desjuan Johnson
NT	Poona Ford	Ty Hamilton
DE	Kobie Turner	Tyler Davis
OLB	Jared Verse	Nick Hampton
ILB	Omar Speights	Shaun Dolac
ILB	Nate Landman	Troy Reeder
CB	Emmanuel Forbes Jr.	Darious Williams
S	Quentin Lake	Kamren Kinchens
S	Kam Curl	Jaylen McCollough
CB	Cobie Durant	Josh Wallace	Tre Brown

This is the Rams' projected depth chart for special teams vs the 49ers:

Position	First	Second	Third	Fourth
P	Ethan Evans
K	Joshua Karty
H	Ethan Evans
LS	Alex Ward
PR	Xavier Smith	Konata Mumpfield
KR	Jordan Whittington	Blake Corum

San Francisco 49ers' depth chart

This is the 49ers' projected depth chart on offense vs the Rams:

Position	First	Second	Third	Fourth
WR	Jauan Jennings	Kendrick Bourne	Marquez Valdes-Scantling
LT	Trent Williams
LG	Connor Colby
C	Jake Brendel	Matt Hennessy
RG	Dominick Puni	Drew Moss
RT	Colton McKivitz	Austen Pleasants
TE	Luke Farrell	Jake Tonges	Brayden Willis
WR	Ricky Pearsall	Skyy Moore	Jordan Watkins
RB	Christian McCaffrey	Brian Robinson Jr.	Isaac Guerendo	Jordan James
FB	Kyle Juszczyk
QB	Brock Purdy	Mac Jones

This is the 49ers' projected depth on defense vs the Rams:

Position	First	Second	Third	Fourth
LDE	Mykel Williams	Bryce Huff
LDT	Kalia Davis	Alfred Collins
RDT	Jordan Elliott	C.J. West	Jordan Jefferson
RDE	Nick Bosa	Yetur Gross-Matos	Sam Okuayinonu
SAM	Luke Gifford	Curtis Robinson
MIKE	Fred Warner	Tatum Bethune
WILL	Dee Winters	Nick Martin
LCB	Renardo Green	Chase Lucas
RCB	Deommodore Lenoir	Darrell Luter Jr.
NB	Upton Stout
FS	Jason Pinnock	Siran Neal
SS	Marques Sigle	Ji'Ayir Brown

This is the 49ers' projected depth chart for special teams vs the Rams:

Position	First	Second	Third	Fourth
P	Thomas Morstead
K	Eddy Piñeiro
H	Thomas Morstead
PR	Skyy Moore	Jordan Watkins
KOR	Isaac Guerendo	Skyy Moore
LS	Jon Weeks

How to watch Rams vs 49ers? TV channel and live stream details for the Week 5 game

The LA Rams will host the San Francisco 49ers at the SoFi Stadium. The Rams have started the season with a 3-1 record. They have recorded wins over the Houston Texans, Tennessee Titans and Indianapolis Colts. Their sole loss was against the Philadelphia Eagles.

The Rams defeated the Colts in Week 4. Matthew Stafford, Puka Nacua and Davante Adams shone in the win. Sean McVay's team is looking to make a push for its second Super Bowl victory of the decade.

The San Francisco 49ers started the season with three consecutive wins. Kyle Shanahan's team came out with a vengeance after a disappointing 2024 campaign. The Niners' three wins this season came against the Seattle Seahawks, New Orleans Saints and Arizona Cardinals.

However, Christian McCaffrey and Co. suffered a loss against the Jacksonville Jaguars in Week 4. The 49ers never got going in the showdown and suffered their first loss of the 2025 season. They'll hope to return to winning ways in tonight's game.

Here's what you need to know about the Rams vs. 49ers:

• Date: Thursday, Oct. 2, 2025
• Livestream: Amazon Prime, FuboTV and DAZN
• Time: 8:15 p.m. ET
• Venue: SoFi Stadium