The Buffalo Bills head to the cold city of Foxboro to take on the New England Patriots as part of "Monday Night Football."Josh Allen and Co. have simply been on fire for the most part since the start of the 2020 season. Allen is having an MVP-like season, leading with the 5th-most passing yards and 7th-most passing touchdowns.As for Buffalo's defense, it has been a huge factor for several wins in the past few weeks, including against the once undefeated Pittsburgh Steelers team. But the offense is what makes the Bills shine this season and something Bill Belichick will have to deal with on MNF.The Patriots had an up and down season, surviving with the likes of Cam Newton and the defense that was left for Belichick to choose from, due to players opting out of the season.It should be a relatively easy game for the Bills, who have already secured a playoff spot. It is a matter of keeping that second seed in the AFC division for them, which should happen for the Bills.Buffalo Bills at New England Patriots betting oddsBills odds: -7.0 (-108)Patriots odds: +7.0 (-112)Spread: Buffalo is a -7.0 favoriteBuffalo Bills at New England Patriots picks1. Josh Allen will have three touchdowns and an interception for the night2. Buffalo's defense will force two fumbles on Cam Newton3. Jarrett Stidham will take center in the second half of the game for the PatriotsBuffalo Bills at New England Patriots key notesThis could be the last start for Cam Newton as a Patriot, considering they have been knocked out of playoff contentionBuffalo is on a four-game win streak and carry the second seed in the AFC playoff divisionThis is the first the Bills have won the AFC East division title since 1995Josh Allen is considered one of the top runners to win the NFL MVP awardThe last time these two teams faced each other, the Bills won 24-21In the red zone Josh Allen now has 36 career passing TDs and 0 INTs #NFL pic.twitter.com/LfqL66U0v7— Bills QB Watch (@BillsQBwatch) December 27, 2020Buffalo Bills at New England Patriots key injuriesBuffalo Bills:TE Reggie Gilliam (knee/hamstring) is outS Jaquan Johnson (ankle) is questionableT Ty Nsekhe (groin) is questionablePatriots-Bills injury report: Damien Harris among 20 Pats questionable for Monday Night Football https://t.co/3NkGHuEqK9— Boston Herald (@bostonherald) December 26, 2020New England Patriots:RB Damien Harris (ankle) is questionableDB Jonathan Jones (neck) is questionableDT Adam Butler (shoulder) is questionableBuffalo Bills at New England Patriots predictionPrediction: Bills 30, Patriots 20Money Line: Bills -350, Patriots +270Against The Spread: Bills 11-3, Patriots 4-10