Seahawks vs. 49ers projected starting lineup and depth chart for Week 1 | 2025 NFL season

The San Francisco 49ers went 6-11 in 2024, just one year after playing in the Super Bowl, as a result of their devastating injury load. The team will try to regain its position as the NFC's dominant power in 2025, now that several of its key roster members are healthy and the team has strengthened during the offseason.

To show that they are contenders in the NFC this year, the Niners will need a strong performance in their opening game of the season on Sunday against NFC West rivals the Seattle Seahawks.

Here are the projected starting lineups for both sides ahead of the Sunday afternoon matchup.

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Seattle Seahawks vs. San Francisco 49ers projected starting lineup for Week 1

Seattle Seahawks projected starting lineup

NFL: Seattle Seahawks quarterback Sam Darnold - Source: Imagn

Below is a look at the Hawks’ projected offensive starters against the 49ers:

Position	Starter
QB	Sam Darnold
RB	Kenneth Walker III
WR	Jaxon Smith-Njigba
WR	Cooper Kupp
WR	Tory Horton
TE	AJ Barner
FB	Robbie Ouzts
LT	Charles Cross
LG	Grey Zabel
C	Jalen Sundell
RT	Anthony Bradford
RG	Abraham Lucas

Below is a look at the Seahawks’ projected defensive starters against the 49ers:

Position	Starter
LDE	Jarran Reed
NT	Byron Murphy II
RDE	Leonard Williams
LLB	Tyrice Knight
RLB	Ernest Jones IV
WLB	DeMarcus Lawrence
SLB	Boye Mafe
RCB	Josh Jobe
LCB	Riq Woolen
SCB	Devon Witherspoon
SS	Coby Bryant
FS	Julian Love

Below is a look at the Seahawks’ projected special teams starters against the 49ers:

Position	Starter
PK	Jason Myers
P	Michael Dickson
H	Michael Dickson
PR	Tory Horton
KR	George Holani
LS	Chris Stoll

San Francisco 49ers projected starting lineup

NFL: San Francisco 49ers quarterback Brock Purdy - Source: Imagn

Below is a look at the 49ers’ projected offensive starters against the Seahawks:

Position	Starter
QB	Brock Purdy
RB	Christian McCaffrey
WR	Jauan Jennings
WR	Ricky Pearsall
WR	Skyy Moore
TE	George Kittle
FB	Kyle Juszczyk
LG	Ben Bartch
LT	Trent Williams
C	Jake Brendel
RG	Dominick Puni
RT	Colton McKivitz

Below is a look at the 49ers’ projected defensive starters against the Seahawks:

Position	Starter
LDE	Mykel Williams
RDE	Nick Bosa
LDT	Kalia Davis
RDT	Jordan Elliott
WLB	Dee Winters
MLB	Fred Warner
SLB	Luke Gifford
RCB	Deommodore Lenoir
LCB	Renardo Green
SCB	Upton Stout
SS	Ji'Ayir Brown
FS	Jason Pinnock

Below is a look at the 49ers’ projected special teams starters against the Seahawks:

Position	Starter
P	Thomas Morstead
K	Jake Moody
LS	Jon Weeks
H	Thomas Morstead
PR	Skyy Moore
KR	Isaac Guerendo

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Seattle Seahawks vs. San Francisco 49ers depth chart

Seattle Seahawks depth chart

Below is a look at the Seahawks’ projected offensive depth chart:

Position	Starter	2nd	3rd	4th
QB	Sam Darnold	Drew Lock	Jalen Milroe	-
RB	Kenneth Walker III	Zach Charbonnet	George Holani	-
WR	Jaxon Smith-Njigba	Jake Bobo	-	-
WR	Cooper Kupp	Dareke Young	-	-
WR	Tory Horton	Cody White	-	-
TE	AJ Barner	Eric Saubert	Elijah Arroyo	Nick Kallerup
FB	Robbie Ouzts	Brady Russell	-	-
LG	Grey Zabel	Jalen Sundell	-	-
LT	Charles Cross	Josh Jones	Mason Richman	-
C	Jalen Sundell	Olu Olutimi	-	-
RG	Anthony Bradford	Jalen Sundell	-	-
RT	Abraham Lucas	Josh Jones	-	-

Below is a look at the Seahawks’ projected defensive depth chart:

Position	Starter	2nd	3rd	4th
LDE	Jarran Reed	-	-	-
NT	Byron Murphy II	Johnathan Hankins	-	-
RDE	Leonard Williams	Mike Morris	-	-
LLB	Tyrice Knight	Drake Thomas	-	-
RLB	Ernest Jones IV	Chazz Surratt	-	-
WLB	DeMarcus Lawrence	Derick Hall	-	-
SLB	Boye Mafe	Uchenna Nwosu	Connor O'Toole	-
LCB	Josh Jobe	Derion Kendrick	-	-
RCB	Riq Woolen	Nehemiah Pritchett	-	-
SCB	Devon Witherspoon	-	-	-
SS	Coby Bryant	Ty Okada	-	-
FS	Julian Love	Nick Emmanwori	AJ Finley	-

Below is a look at the Seahawks’ projected special teams depth chart:

Position	Starter	2nd	3rd	4th
PK	Jason Myers	-	-	-
P	Michael Dickson	-	-	-
H	Michael Dickson	-	-	-
PR	Tory Horton	Jake Bobo	-	-
KR	George Holani	Dareke Young	-	-
LS	Chris Stoll	-	-	-

San Francisco 49ers depth chart

Below is a look at the 49ers’ projected offensive depth chart:

Position	Starter	2nd	3rd	4th
QB	Brock Purdy	Mac Jones	Kurtis Rourke	-
RB	Christian McCaffrey	Brian Robinson Jr.	Isaac Guerendo	Jordan James
WR	Jauan Jennings	Marquez Valdes-Scantling-	Demarcus Robinson	-
WR	Ricky Pearsall	Jordan Watkins	Jacob Cowing	-
WR	Brandon Aiyuk	Skyy Moore	Trent Taylor	-
TE	George Kittle	Luke Farrell	Jake Tonges
FB	Kyle Juszczyk
LG	Ben Bartch	Connor Colby
LT	Trent Williams	Spencer Burford	-	-
C	Jake Brendel	Matt Hennessy	-	-
RG	Dominick Puni	Drew Moss	-	-
RT	Colton McKivitz	Austen Pleasants	Isaac Alarcon	-

Below is a look at the 49ers’ projected offensive depth chart:

Position	Starter	2nd	3rd	4th
LDE	Mykel Williams	Yetur Gross-Matos	Bryce Huff	-
RDE	Nick Bosa	Sam Okuayinonu	Robert Beal Jr.	Tarron Jackson
LDT	Kalia Davis	Alfred Collins	Kevin Givens	-
RDT	Jordan Elliott	CJ West	Jordan Jefferson	-
WLB	Dee Winters	Nick Martin	-	-
MLB	Fred Warner	Tatum Bethune	-	-
SLB	Luke Gifford	-	-	-
RCB	Deommodore Lenoir	Darrell Luter Jr.	Jakob Robinson	-
LCB	Renardo Green	Tre'Vius Hodges-Tomlinson	-	-
SCB	Upton Stout	Chase Lucas	-	-
FS	Jason Pinnock	Marques Sigle	Malik Mustapha	-
SS	Ji'Ayir Brown	Siran Neal	-	-

Below is a look at the 49ers’ projected special teams depth chart:

Position	Starter	2nd	3rd	4th
P	Thomas Morstead	-	-	-
PK	Jake Moody	-	-	-
LS	Jon Weeks	-	-	-
H	Thomas Morstead	-	-	-
PR	Skyy Moore	Jordan Watkins	Jacob Cowing	-
KR	Isaac Guerendo	Skyy Moore	-	-

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How to watch the Seahawks vs. 49ers Week 1 game? TV schedule and live stream details

The Seahawks vs. 49ers game will be broadcast live on FOX at 4:05 p.m. ET on Sunday. Fans can also live stream the game on FuboTV.

Joe Davis will be on call duties as the play-by-play commentator, while Greg Olsen will join him in the booth as the color analyst. Pam Oliver will be reporting from the sidelines.

Here are the details you need to watch the Seahawks vs. 49ers Week 1 game:

Date: Sunday, Sept. 7, 2025

Time: 4:05 p.m. ET

Venue: Lumen Field, Seattle, Washington

TV channel: FOX

Announcers: Joe Davis (play-by-play), Greg Olsen (color analyst), Pam Oliver (sideline reporter)

Live stream: FuboTV