Southpaw Regional Wrestling is an online video series produced by WWE and created by Brian Pellegatto. It is fictional professional wrestling under the genre of Comedy/Sports. The video series is a parody of the professional wrestling promotions that used to take place in the Southern states in the 1980s. A total of 12 episodes have been telecasted over two seasons on WWE's official website, YouTube and the WWE Network.
Southpaw Regional Wrestling was a huge hit. No one could have predicted that what started as a promotional tie-in between WWE and Kentucky Fried Chicken would do so remarkably well. After the success of Season 1, which received more than 2.5 million views on YouTube, fans were eagerly waiting for Season 2. The second season of Southpaw Regional Wrestling was finally announced in May 2017 by John Cena. Season 2 of Southpaw Regional Wrestling was aired in August 2018. However, Season 2 failed to continue what Season 1 had established and was not received warmly by the fans. Although the premise still has a lot of potentials, a third installment of the Southpaw Regional Wrestling seems very unlikely.
| Character | Portrayed by | WWE Ring name |
| Chad 2 Badd | Chad Allegra | Karl Anderson |
| Big Bartholomew | Miroslav Barnyashev | Rusev |
| Sea Creature | unknown | unknown |
| Tex Ferguson | Drew Hankinson | Luke Gallows |
| La Barba Grande | Jon Huber | Luke Harper |
| John Johnson | T.J. Perkins | TJP |
| Christian Joy | C.J. Perry | Lana |
| Mr. Mackelroy | Matt Clement | Tyler Breeze |
| Surf Dudes with Attitudes | Ryan Parmeter and Eric Thompson | Konnor and Viktor |
| Impressive Pelvis Wesley | Heath Miller | Heath Slater |
| "Dry Rub" Doug | Colby Lopez | Seth Rollins |
| Frantic Frank | Terrance Guido Gerin | Rhyno |
| Nicci Lee Styxxx | Nicholas Nemeth | Dolph Ziggler |
| Voo | Austin Watson | Xavier Woods |
| Doo | Ettore Ewen | Big E |
| Porkchop Jones | Nathan Everhart | Jason Jordan |
| "Astonishing" Adam Düng | Michael Mizanin | The Miz |
| René Beret | Bryan Danielson | Daniel Bryan |
| Dan Bandana | Bryan Danielson | Daniel Bryan |
| Dewey Jackson | Michael Seitz | Michael Hayes |
| Danger Zone | Ryan Parmeter and Eric Thompson | Konnor and Viktor |
| Debbie Desperado | Natalie Neidhart | Natalya |
| Character | Portrayed by | WWE Ring name |
| Cameron "Clint" Bobski (backstage interviewer) | Christopher Irvine | Chris Jericho |
| Lance Catamaran (studio host) | John Cena | John Cena |
| Chett Chetterfield (studio host) | Curtis Hussey | Fandango |
| Chip Henderson (referee) | John Cone | John Cone |
| Malibu Al (sponsor) | Allen Jones | A.J. Styles |
| Susan (backstage interviewer) | Renee Paquette | Renee Young |
| janitor | Adam Pearce | Adam Pearce |
| unnamed | Anthony Carelli | Santino Marella |
| boat driver | unknown | unknown |
| La Barba grande's presenter (voice only) | Carlos Cabrera | Carlos Cabrera |
